Academic lineage
CRISPR-Cas12a base editors confer efficient multiplexed genome editing in rice
- Yanhao Cheng, Yingxiao Zhang, Gen Li, …, Jianping Xu, Qiudeng Que, Yiping Qi
- Plant Commun, 10.1016/j.xplc.2023.100601
Transcriptomic reprogramming for neuronal age reversal
- Alexandru M Plesa, Michael Shadpour, Ed Boyden, …, Michael Shadpour, Ed Boyden, George M Church
- Hum Genet, 10.1007/s00439-023-02529-1
Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity
- Eric Dec, James Clement, Kaiyang Cheng, …, Paolo Garagnani, Claudio Franceschi, Steve Horvath
- Geroscience, 10.1007/s11357-023-00731-7
Correction: Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression
- Merrick D Pierson Smela, Christian C Kramme, Patrick R J Fortuna, …, Toshi Shioda, Pranam Chatterjee, George M Church
- Elife, 10.7554/elife.87987
A swapped genetic code prevents viral infections and gene transfer
- Svenja Vinke, Regan Flynn, Siân V Owen, …, Fangxiang Hu, Michael Baym, George M Church
- Nature, 10.1038/s41586-023-05824-z
oFlowSeq: a quantitative approach to identify protein coding mutations affecting cell type enrichment using mosaic CRISPR-Cas9 edited cerebral organoids
- Pepper Dawes, Liam F Murray, Meagan N Olson, …, George M Church, Yingleong Chan, Elaine T Lim
- Hum Genet, 10.1007/s00439-023-02534-4
Light and carbon: Synthetic biology toward new cyanobacteria-based living biomaterials
- Isabella M Goodchild-Michelman, George M Church, Max G Schubert, …, George M Church, Max G Schubert, Tzu-Chieh Tang
- None, 10.1016/j.mtbio.2023.100583
Unlocking the magic in mycelium: Using synthetic biology to optimize filamentous fungi for biomanufacturing and sustainability
- Charles Jo, Jing Zhang, Jenny M Tam, …, Ahmad S Khalil, Daniel Segrè, Tzu-Chieh Tang
- None, 10.1016/j.mtbio.2023.100560
Genes drive organisms and slippery slopes
- David B Resnik, Raul F Medina, Fred Gould, George Church, Jennifer Kuzma
- Pathog Glob Health, 10.1080/20477724.2022.2160895
Efficient modification and preparation of circular DNA for expression in cell culture
- George M Church, George M Church, Roman Teo Oliynyk, George M Church, Roman Teo Oliynyk, George M Church
- Commun Biol, 10.1038/s42003-022-04363-z
Engineered Living Materials For Sustainability
- Bolin An, Yanyi Wang, Yuanyuan Huang, …, Xiao Yi, Tzu-Chieh Tang, Chao Zhong
- Chem Rev, 10.1021/acs.chemrev.2c00512
How to grow (almost) anything: a hybrid distance learning model for global laboratory-based synthetic biology education
- Eyal Perry, Jessica Weber, Pat Pataranutaporn, …, Joseph Jacobson, George Church, David Kong
- Nat Biotechnol, 10.1038/s41587-022-01601-x
Picogram-Scale Interstellar Probes via Bioinspired Engineering
- George Church, George Church, George Church, George Church
- Astrobiology, 10.1089/ast.2022.0008
Reconstruction of the gastric cancer microenvironment after neoadjuvant chemotherapy by longitudinal single-cell sequencing
- Yingtai Chen, Jianhua Yin, Lulu Zhao, …, George Church, Guibo Li, Dongbing Zhao
- J Transl Med, 10.1186/s12967-022-03792-y
An Interpretable Deep Embedding Model for Few and Imbalanced Biomedical Data
- Haishuai Wang, Li Li, Jiali Ma, …, Lianhua Chi, Jun Wu, Ziping Zhao
- IEEE J Biomed Health Inform, 10.1109/jbhi.2022.3223798
A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules
- Donghyun Lim, Qingxuan Zhou, Kurt J Cox, …, Christina M Woo, George M Church, Amit Choudhary
- Nat Cell Biol, 10.1038/s41556-022-01005-8
Publisher Correction: Single-sequence protein structure prediction using a language model and deep learning
- Ratul Chowdhury, Nazim Bouatta, Surojit Biswas, …, George M Church, Peter K Sorger, Mohammed AlQuraishi
- Nat Biotechnol, 10.1038/s41587-022-01556-z
Recombineering and MAGE
- Timothy M Wannier, Peter N Ciaccia, Andrew D Ellington, …, Csaba Pal, Max G Schubert, George M Church
- None, 10.1038/s43586-020-00006-x
Discovery and validation of human genomic safe harbor sites for gene and cell therapies
- Erik Aznauryan, Alexander Yermanos, Elvira Kinzina, …, Denitsa Milanova, George M Church, Sai T Reddy
- Cell Rep Methods, 10.1016/j.crmeth.2021.100154
An integrated pipeline for mammalian genetic screening
- Christian Kramme, Alexandru M Plesa, Helen H Wang, …, Richie E Kohman, Pranam Chatterjee, George M Church
- Cell Rep Methods, 10.1016/j.crmeth.2021.100082
Results of a 5-Year N-of-1 Growth Hormone Releasing Hormone Gene Therapy Experiment
- Brian P Hanley, Keith Brewer, George Church
- Rejuvenation Res, 10.1089/rej.2021.0036
Framework for rapid comparison of extracellular vesicle isolation methods
- Dmitry Ter-Ovanesyan, Maia Norman, Roey Lazarovits, …, Ju-Hyun Lee, George M Church, David R Walt
- Elife, 10.7554/elife.70725
MegaGate: A toxin-less gateway molecular cloning tool
- Christian Kramme, Alexandru M Plesa, Helen H Wang, …, Richie E Kohman, Pranam Chatterjee, George M Church
- STAR Protoc, 10.1016/j.xpro.2021.100907
Delivery of biomacromolecules for therapeutic genome editing
- Yuan Ping, George M Church
- Adv Drug Deliv Rev, 10.1016/j.addr.2020.12.013
Characterizing the portability of phage-encoded homologous recombination proteins
- Timothy M Wannier, Felix B Pedersen, Isaac D Lutz, …, John Aach, Michael T Laub, George M Church
- Nat Chem Biol, 10.1038/s41589-020-00710-5
In situ genome sequencing resolves DNA sequence and structure in intact biological samples
- Andrew C Payne, Zachary D Chiang, Paul L Reginato, …, Edward S Boyden, Jason D Buenrostro, Fei Chen
- Science, 10.1126/science.aay3446
Transparency is key to ethical vaccine research-Response
- Arthur Caplan, Alison Bateman-House
- Science, 10.1126/science.abf7809
Core commitments for field trials of gene drive organisms
- Kanya C Long, Luke Alphey, George J Annas, …, Jolene T Sutton, Adam E Vorsino, Omar S Akbari
- Science, 10.1126/science.abd1908
The biosecurity benefits of genetic engineering attribution
- Gregory Lewis, Jacob L Jordan, David A Relman, …, Kevin M Esvelt, Elizabeth E Cameron, Thomas V Inglesby
- Nat Commun, 10.1038/s41467-020-19149-2
A machine learning toolkit for genetic engineering attribution to facilitate biosecurity
- Ethan C Alley, Miles Turpin, Andrew Bo Liu, …, Stephen E Von Stetina, George M Church, Kevin M Esvelt
- Nat Commun, 10.1038/s41467-020-19612-0
Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions
- Pranam Chatterjee, Manvitha Ponnapati, Christian Kramme, Alexandru M Plesa, George M Church, Joseph M Jacobson
- Commun Biol, 10.1038/s42003-020-01470-7
Pluripotent stem cell-derived CAR-macrophage cells with antigen-dependent anti-cancer cell functions
- Li Zhang, Lin Tian, Xiaoyang Dai, …, He Huang, Qinjie Weng, Jin Zhang
- J Hematol Oncol, 10.1186/s13045-020-00983-2
Reactions to the National Academies/Royal Society Report on Heritable Human Genome Editing
- Misha Angrist, Rodolphe Barrangou, Françoise Baylis, …, Robert Williamson, Feng Zhang, Kevin Davies
- CRISPR J, 10.1089/crispr.2020.29106.man
Extensive germline genome engineering in pigs
- Yanan Yue, Weihong Xu, Yinan Kan, …, Hong-Jiang Wei, George M Church, Luhan Yang
- Nat Biomed Eng, 10.1038/s41551-020-00613-9
Global citizen deliberation on genome editing
- John S Dryzek, Dianne Nicol, Simon Niemeyer, …, John E J Rasko, Ine Van Hoyweghen, Antoine Vergne
- Science, 10.1126/science.abb5931
TBDB: a database of structurally annotated T-box riboswitch:tRNA pairs
- Jorge A Marchand, Merrick D Pierson Smela, Thomas H H Jordan, Kamesh Narasimhan, George M Church
- Nucleic Acids Res, 10.1093/nar/gkaa721
Korean Genome Project: 1094 Korean personal genomes with clinical information
- Sungwon Jeon, Youngjune Bhak, Yeonsong Choi, …, George Church, Semin Lee, Jong Bhak
- Sci Adv, 10.1126/sciadv.aaz7835
The whale shark genome reveals how genomic and physiological properties scale with body size
- Jessica A Weber, Seung Gu Park, Victor Luria, …, Jeremy S Edwards, Jong Bhak, George M Church
- Proc Natl Acad Sci U S A, 10.1073/pnas.1922576117
3D mapping and accelerated super-resolution imaging of the human genome using in situ sequencing
- Huy Q Nguyen, Shyamtanu Chattoraj, David Castillo, …, Evan R Daugharthy, Marc A Marti-Renom, C-Ting Wu
- Nat Methods, 10.1038/s41592-020-0890-0