In vivo hypermutation and continuous evolution
- Rosana S Molina, Gordon Rix, Amanuella A Mengiste, …, Luis Ángel Fernández, Matthew D Shoulders, Chang C Liu
- None, 10.1038/s43586-022-00130-w
Long-term evolution of proliferating cells using the eVOLVER platform
- Daniel Garc A-Ruano, Akanksha Jain, Zachary J Heins, …, Ezira Yimer Wolle, Ahmad S Khalil, Damien Coudreuse
- None, 10.1101/2023.03.28.534552
Effects of Antibiotic Interaction on Antimicrobial Resistance Development in Wastewater
- Indorica Sutradhar, Carly Ching, Darash Desai, …, Zachary Heins, Ahmad S Khalil, Muhammad H Zaman
- None, 10.1101/2023.02.10.528009
Unlocking the magic in mycelium: Using synthetic biology to optimize filamentous fungi for biomanufacturing and sustainability
- Charles Jo, Jing Zhang, Jenny M Tam, …, Ahmad S Khalil, Daniel Segrè, Tzu-Chieh Tang
- None, 10.1016/j.mtbio.2023.100560
The sound of silence: Transgene silencing in mammalian cell engineering
- Alan Cabera, Hailey I Edelstein, Fokion Glykofrydis, …, Lacramioara Bintu, Kate E Galloway, Tara L Deans
- Cell Syst, 10.1016/j.cels.2022.11.005
Multidimensional control of therapeutic human cell function with synthetic gene circuits
- Hui-Shan Li, Divya V Israni, Keith A Gagnon, …, J Keith Joung, Wilson W Wong, Ahmad S Khalil
- Science, 10.1126/science.ade0156
Recent progress of gene circuit designs in immune cell therapies
- Seunghee Lee, Ahmad S Khalil, Wilson W Wong, Seunghee Lee, Ahmad S Khalil, Wilson W Wong
- Cell Syst, 10.1016/j.cels.2022.09.006
A Toolkit for Precise, Multigene Control in Saccharomyces cerevisiae
- Adam Sanford, Szilvia Kiriakov, Ahmad S Khalil, …, Adam Sanford, Szilvia Kiriakov, Ahmad S Khalil
- ACS Synth Biol, 10.1021/acssynbio.2c00423
High-performance multiplex drug-gated CAR circuits
- Hui-Shan Li, Nicole M Wong, Elliot Tague, …, John T Ngo, Ahmad S Khalil, Wilson W Wong
- Cancer Cell, 10.1016/j.ccell.2022.08.008
High-throughput continuous evolution of compact Cas9 variants targeting single-nucleotide-pyrimidine PAMs
- Tony P Huang, Zachary J Heins, Shannon M Miller, …, Tina Wang, Ahmad S Khalil, David R Liu
- Nat Biotechnol, 10.1038/s41587-022-01410-2
Modular design of synthetic receptors for programmed gene regulation in cell therapies
- Iowis Zhu, Raymond Liu, Julie M Garcia, …, Bin Liu, Ahmad S Khalil, Kole T Roybal
- Cell, 10.1016/j.cell.2022.03.023
Computational Model To Quantify the Growth of Antibiotic-Resistant Bacteria in Wastewater
- Indorica Sutradhar, Carly Ching, Darash Desai, …, Zachary Heins, Ahmad S Khalil, Muhammad H Zaman
- mSystems, 10.1128/msystems.00360-21
Here to stay: Writing lasting epigenetic memories
- Hagar F Moussa, James F Angstman, Ahmad S Khalil
- Cell, 10.1016/j.cell.2021.04.007
A Code of Ethics for Gene Drive Research
- George J Annas, Chase L Beisel, Kendell Clement, …, Alekos Simoni, Chrysanthi Taxiarchi, J Keith Joung
- CRISPR J, 10.1089/crispr.2020.0096
Barcoded microbial system for high-resolution object provenance
- Jason Qian, Zhi-Xiang Lu, Christopher P Mancuso, …, Pamela A Silver, David Z Rudner, Michael Springer
- Science, 10.1126/science.aba5584
Protein assembly systems in natural and synthetic biology
- Giulio Chiesa, Szilvia Kiriakov, Ahmad S Khalil
- BMC Biol, 10.1186/s12915-020-0751-4
Sphingomonas solaris sp. nov., isolated from a solar panel in Boston, Massachusetts
- Kristie Tanner, Christopher P Mancuso, Juli Peretó, Ahmad S Khalil, Cristina Vilanova, Javier Pascual
- Int J Syst Evol Microbiol, 10.1099/ijsem.0.003977
Designing Automated, High-throughput, Continuous Cell Growth Experiments Using eVOLVER
- Zachary J Heins, Christopher P Mancuso, Szilvia Kiriakov, Brandon G Wong, Caleb J Bashor, Ahmad S Khalil
- J Vis Exp, 10.3791/59652
Complex signal processing in synthetic gene circuits using cooperative regulatory assemblies
- Caleb J Bashor, Nikit Patel, Sandeep Choubey, …, Jané Kondev, James J Collins, Ahmad S Khalil
- Science, 10.1126/science.aau8287
Functional genomics of the rapidly replicating bacterium Vibrio natriegens by CRISPRi
- Henry H Lee, Nili Ostrov, Brandon G Wong, Michaela A Gold, Ahmad S Khalil, George M Church
- Nat Microbiol, 10.1038/s41564-019-0423-8
Engineering Epigenetic Regulation Using Synthetic Read-Write Modules
- Minhee Park, Nikit Patel, Albert J Keung, Ahmad S Khalil
- Cell, 10.1016/j.cell.2018.11.002
Modeling the impact of drug interactions on therapeutic selectivity
- Zohar B Weinstein, Nurdan Kuru, Szilvia Kiriakov, …, Muhammad H Zaman, Frederick P Roth, Murat Cokol
- Nat Commun, 10.1038/s41467-018-05954-3
Precise, automated control of conditions for high-throughput growth of yeast and bacteria with eVOLVER
- Brandon G Wong, Christopher P Mancuso, Szilvia Kiriakov, Caleb J Bashor, Ahmad S Khalil
- Nat Biotechnol, 10.1038/nbt.4151
Hsf1 Phosphorylation Generates Cell-to-Cell Variation in Hsp90 Levels and Promotes Phenotypic Plasticity
- Xu Zheng, Ali Beyzavi, Joanna Krakowiak, Nikit Patel, Ahmad S Khalil, David Pincus
- Cell Rep, 10.1016/j.celrep.2018.02.083
Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response
- Joanna Krakowiak, Xu Zheng, Nikit Patel, …, David S Gross, Ahmad S Khalil, David Pincus
- Elife, 10.7554/elife.31668
Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells
- Zohar Shipony, Zohar Mukamel, Netta Mendelson Cohen, …, Elena Ainbinder, Nir Friedman, Amos Tanay
- Nature, 10.1038/nature13458