Unraveling Heterogeneity in the Aging Hematopoietic Stem Cell Compartment: An Insight From Single-cell Approaches
- Fei Yang, Craig Nourse, G Vignir Helgason, …, Craig Nourse, G Vignir Helgason, Kristina Kirschner
- None, 10.1097/hs9.0000000000000895
Identification of curaxin as a potential new therapeutic for JAK2 V617F mutant patients
- Stella Pearson, Rognvald Blance, Fei Yan, …, Kristina Kirschner, Anthony D Whetton, Andrew Pierce
- PLoS One, 10.1371/journal.pone.0286412
Locus-specific induction of gene expression from heterochromatin loci during cellular senescence
- Kosuke Tomimatsu, Dóra Bihary, Ioana Olan, …, Masako Narita, Shamith A Samarajiwa, Masashi Narita
- Nat Aging, 10.1038/s43587-021-00147-y
Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis
- Eoin D O’Sullivan, Katie J Mylonas, Rachel Bell, …, Laura Denby, Hassan Dihazi, David A Ferenbach
- JCI Insight, 10.1172/jci.insight.154124
Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects
- Neil A Robertson, Eric Latorre-Crespo, Maria Terradas-Terradas, …, Linus J Schumacher, Kristina Kirschner, Tamir Chandra
- Nat Med, 10.1038/s41591-022-01883-3
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix
- Emily J Kay, Karla Paterson, Carla Riera-Domingo, …, Karen Blyth, Michele Zagnoni, Sara Zanivan
- Nat Metab, 10.1038/s42255-022-00582-0
p57Kip2 regulates embryonic blood stem cells by controlling sympathoadrenal progenitor expansion
- Chrysa Kapeni, Leslie Nitsche, Alastair M Kilpatrick, …, Kristina Kirschner, Simon R Tomlinson, Katrin Ottersbach
- Blood, 10.1182/blood.2021014853