Academic lineage
Coupled protein quality control during nonsense-mediated mRNA decay
- Alison J Inglis, Alina Guna, Ángel Gálvez-Merchán, …, Robert Oania, Jonathan S Weissman, Rebecca M Voorhees
- J Cell Sci, 10.1242/jcs.261216
FET fusion oncoproteins disrupt physiologic DNA repair networks in cancer
- Shruti Menon, Marcus R Breese, Yone Phar Lin, …, E Alejandro Sweet-Cordero, Trever G Bivona, Asmin Tulpule
- None, 10.1101/2023.04.30.538578
Translational fidelity screens in mammalian cells reveal eIF3 and eIF4G2 as regulators of start codon selectivity
- Richard She, Jingchuan Luo, Jonathan S Weissman, …, Richard She, Jingchuan Luo, Jonathan S Weissman
- Nucleic Acids Res, 10.1093/nar/gkad329
Comparative landscape of genetic dependencies in human and chimpanzee stem cells
- Richard She, Tyler Fair, Nathan K Schaefer, …, Bryan J Pavlovic, Jonathan S Weissman, Alex A Pollen
- None, 10.1101/2023.03.19.533346
A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens
- Alina Guna, Katharine R Page, Joseph R Replogle, …, Maxine L Wang, Jonathan S Weissman, Rebecca M Voorhees
- None, 10.1101/2023.01.22.525086
Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors
- Joseph M Replogle, Jessica L Bonnar, Angela N Pogson, …, Martin Kampmann, Jonathan S Weissman, Marco Jost
- Elife, 10.7554/elife.81856
Dual genome-wide coding and lncRNA screens in neural induction of induced pluripotent stem cells
- David Wu, Aunoy Poddar, Elpiniki Ninou, …, Yin Shen, Jonathan S Weissman, Daniel A Lim
- None, 10.1016/j.xgen.2022.100177
MTCH2 is a mitochondrial outer membrane protein insertase
- Alina Guna, Taylor A Stevens, Alison J Inglis, …, Tsui-Fen Chou, Jonathan S Weissman, Rebecca M Voorhees
- Science, 10.1126/science.add1856
Cellular barcoding to decipher clonal dynamics in disease
- Vijay G Sankaran, Jonathan S Weissman, Leonard I Zon, …, Vijay G Sankaran, Jonathan S Weissman, Leonard I Zon
- Science, 10.1126/science.abm5874
Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice
- Anna Celli, Yanmin Yao, Yong Zi Tan, …, John L Rubinstein, Marco Jost, Jonathan S Weissman
- Nat Biotechnol, 10.1038/s41587-022-01386-z
Body condition, skin bacterial communities and disease status: insights from the first release trial of the limosa harlequin frog, Atelopus limosus
- Angie Estrada, Daniel Medina, Brian Gratwicke, …, Brian Gratwicke, Roberto Ibáñez, Lisa K Belden
- Proc Biol Sci, 10.1098/rspb.2022.0586
A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities
- Hao Shao, Shuhei Taguwa, Luke Gilbert, …, Jonathan Weissman, Jason E Gestwicki, Judith Frydman
- Cell Chem Biol, 10.1016/j.chembiol.2022.06.006
Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq
- Joseph M Replogle, Reuben A Saunders, Angela N Pogson, …, Marco Jost, Thomas M Norman, Jonathan S Weissman
- Cell, 10.1016/j.cell.2022.05.013
Variant to function mapping at single-cell resolution through network propagation
- Fulong Yu, Liam D Cato, Chen Weng, …, Jonathan S Weissman, Adam J de Smith, Vijay G Sankaran
- Nat Biotechnol, 10.1038/s41587-022-01341-y
Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution
- Dian Yang, Matthew G Jones, Santiago Naranjo, …, Nir Yosef, Tyler Jacks, Jonathan S Weissman
- Cell, 10.1016/j.cell.2022.04.015
OpenCell: Endogenous tagging for the cartography of human cellular organization
- Nathan H Cho, Keith C Cheveralls, Andreas-David Brunner, …, Loïc A Royer, Matthias Mann, Manuel D Leonetti
- Science, 10.1126/science.abi6983
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2
- Avi J Samelson, Quang Dinh Tran, Rémy Robinot, …, Marco Vignuzzi, Ruilin Tian, Martin Kampmann
- Nat Cell Biol, 10.1038/s41556-021-00821-8
The dark proteome: translation from noncanonical open reading frames
- Bradley W Wright, Zixin Yi, Jonathan S Weissman, …, Zixin Yi, Jonathan S Weissman, Jin Chen
- Trends Cell Biol, 10.1016/j.tcb.2021.10.010
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes
- Peter J Chen, Jeffrey A Hussmann, Jun Yan, …, Jonathan S Weissman, Britt Adamson, David R Liu
- Cell, 10.1016/j.cell.2021.09.018
Structured elements drive extensive circular RNA translation
- Chun-Kan Chen, Ran Cheng, Janos Demeter, …, Eran Segal, Peter K Jackson, Howard Y Chang
- Mol Cell, 10.1016/j.molcel.2021.07.042
Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells
- Maxence Le Vasseur, Jonathan Friedman, Marco Jost, …, Brett S Phinney, Jonathan S Weissman, Jodi Nunnari
- Elife, 10.7554/elife.67624
CRISPR-based functional genomics in human dendritic cells
- Marco Jost, Amy N Jacobson, Jeffrey A Hussmann, Giana Cirolia, Michael A Fischbach, Jonathan S Weissman
- Elife, 10.7554/elife.65856
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing
- James K Nuñez, Jin Chen, Greg C Pommier, …, Volker Hovestadt, Luke A Gilbert, Jonathan S Weissman
- Cell, 10.1016/j.cell.2021.03.025
Regulation of translation by methylation multiplicity of 18S rRNA
- Kuanqing Liu, Daniel A Santos, Jeffrey A Hussmann, …, Benjamin M Sutter, Jonathan S Weissman, Benjamin P Tu
- Cell Rep, 10.1016/j.celrep.2021.108825
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
- Lei S Qi, Matthew H Larson, Luke A Gilbert, …, Jonathan S Weissman, Adam P Arkin, Wendell A Lim
- Cell, 10.1016/j.cell.2021.01.019
Genome-Scale Perturbation of Long Noncoding RNA Expression Using CRISPR Interference
- S John Liu, Max A Horlbeck, Jonathan S Weissman, Daniel A Lim
- Methods Mol Biol, 10.1007/978-1-0716-1158-6_20
Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing
- Ashley Maynard, Caroline E McCoach, Julia K Rotow, …, Collin M Blakely, Spyros Darmanis, Trever G Bivona
- Cell, 10.1016/j.cell.2020.07.017
Inference of single-cell phylogenies from lineage tracing data using Cassiopeia
- Matthew G Jones, Alex Khodaverdian, Jeffrey J Quinn, …, Chenling Xu, Jonathan S Weissman, Nir Yosef
- Genome Biol, 10.1186/s13059-020-02000-8
CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma
- S John Liu, Martina Malatesta, Brian V Lien, …, David R Raleigh, Erik M Ullian, Daniel A Lim
- Genome Biol, 10.1186/s13059-020-01995-4
Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing
- Joseph M Replogle, Thomas M Norman, Albert Xu, …, Tarjei S Mikkelsen, Jonathan S Weissman, Britt Adamson
- Nat Biotechnol, 10.1038/s41587-020-0470-y
Development of a Laboratory-safe and Low-cost Detection Protocol for SARS-CoV-2 of the Coronavirus Disease 2019 (COVID-19)
- Joungha Won, Solji Lee, Myungsun Park, …, Hyeshik Chang, V Narry Kim, C Justin Lee
- None, 10.5607/en20009
Author Correction: Reply to: Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes
- Ying Liu, Zhiheng Liu, Zhongzheng Cao, Wensheng Wei
- Nat Biotechnol, 10.1038/s41587-020-0475-6
Pervasive functional translation of noncanonical human open reading frames
- Jin Chen, Andreas-David Brunner, J Zachery Cogan, …, Matthias Mann, Manuel D Leonetti, Jonathan S Weissman
- Science, 10.1126/science.aay0262
Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs
- Marco Jost, Daniel A Santos, Reuben A Saunders, …, Christina R Liem, Carol A Gross, Jonathan S Weissman
- Nat Biotechnol, 10.1038/s41587-019-0387-5
The microtubule regulator ringer functions downstream from the RNA repair/splicing pathway to promote axon regeneration
- Ernest J Monahan Vargas, Andrew J Matamoros, Jingyun Qiu, …, Yuh Nung Jan, Swati Banerjee, Yuanquan Song
- Genes Dev, 10.1101/gad.331330.119
The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins
- Ashley M Ngo, Matthew J Shurtleff, Katerina D Popova, Jessie Kulsuptrakul, Jonathan S Weissman, Andreas S Puschnik
- Elife, 10.7554/elife.48469
New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells
- Laia Bassaganyas, Stephanie J Popa, Max Horlbeck, …, Vivek Malhotra, Kevin Moreau, Julien Villeneuve
- J Cell Biol, 10.1083/jcb.201902028
Exploring genetic interaction manifolds constructed from rich single-cell phenotypes
- Thomas M Norman, Max A Horlbeck, Joseph M Replogle, …, Marco Jost, Luke A Gilbert, Jonathan S Weissman
- Science, 10.1126/science.aax4438
MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices
- Christopher S McGinnis, David M Patterson, Juliane Winkler, …, Zena Werb, Eric D Chow, Zev J Gartner
- Nat Methods, 10.1038/s41592-019-0433-8
Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress
- Aeid Igbaria, Philip I Merksamer, Ala Trusina, …, Nevan J Krogan, Jonathan S Weissman, Feroz R Papa
- Proc Natl Acad Sci U S A, 10.1073/pnas.1904516116
Molecular recording of mammalian embryogenesis
- Michelle M Chan, Zachary D Smith, Stefanie Grosswendt, …, Nir Yosef, Alexander Meissner, Jonathan S Weissman
- Nature, 10.1038/s41586-019-1184-5
Cycloheximide can distort measurements of mRNA levels and translation efficiency
- Daniel A Santos, Lei Shi, Benjamin P Tu, Jonathan S Weissman
- Nucleic Acids Res, 10.1093/nar/gkz205
Cellular response to small molecules that selectively stall protein synthesis by the ribosome
- Nadège Liaud, Max A Horlbeck, Luke A Gilbert, Ketrin Gjoni, Jonathan S Weissman, Jamie H D Cate
- PLoS Genet, 10.1371/journal.pgen.1008057
Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids
- Manuele Piccolis, Laura M Bond, Martin Kampmann, …, Jonathan S Weissman, Tobias C Walther, Robert V Farese
- Mol Cell, 10.1016/j.molcel.2019.01.036
Ribosome Profiling: Global Views of Translation
- Nicholas T Ingolia, Jeffrey A Hussmann, Jonathan S Weissman
- Cold Spring Harb Perspect Biol, 10.1101/cshperspect.a032698