Integrative identification of non-coding regulatory regions driving metastatic prostate cancer
- Brian J Woo, Ruhollah Moussavi-Baygi, Heather Karner, …, Hosseinali Asgharian, Felix Y Feng, Hani Goodarzi
- None, 10.1101/2023.04.14.535921
ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway
- Songnan Wang, Volker Böhnert, Alby J Joseph, …, Luke A Gilbert, Hani Goodarzi, Lingyin Li
- None, 10.1101/2023.06.01.543353
Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors
- Joseph M Replogle, Jessica L Bonnar, Angela N Pogson, …, Martin Kampmann, Jonathan S Weissman, Marco Jost
- Elife, 10.7554/elife.81856
IFITM proteins assist cellular uptake of diverse linked chemotypes
- Kevin Lou, Douglas R Wassarman, Tangpo Yang, …, Jack Taunton, Luke A Gilbert, Kevan M Shokat
- Science, 10.1126/science.abl5829
The 5-Hydroxymethylcytosine Landscape of Prostate Cancer
- Martin Sjöström, Shuang G Zhao, Samuel Levy, …, Alexander W Wyatt, David A Quigley, Felix Y Feng
- Cancer Res, 10.1158/0008-5472.can-22-1123
Highly efficient generation of isogenic pluripotent stem cell models using prime editing
- Hanqin Li, Oriol Busquets, Yogendra Verma, …, Donald C Rio, Dirk Hockemeyer, Frank Soldner
- Elife, 10.7554/elife.79208
A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities
- Hao Shao, Shuhei Taguwa, Luke Gilbert, …, Jonathan Weissman, Jason E Gestwicki, Judith Frydman
- Cell Chem Biol, 10.1016/j.chembiol.2022.06.006
A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments
- Boyang Zhao, Yiyun Rao, Scott Leighow, Edward P O’Brien, Luke Gilbert, Justin R Pritchard
- Nat Commun, 10.1038/s41467-022-28045-w
A global cancer data integrator reveals principles of synthetic lethality, sex disparity and immunotherapy
- Christopher Yogodzinski, Abolfazl Arab, Justin R Pritchard, Hani Goodarzi, Luke A Gilbert
- Genome Med, 10.1186/s13073-021-00987-8
A new era in functional genomics screens
- Laralynne Przybyla, Luke A Gilbert
- Nat Rev Genet, 10.1038/s41576-021-00409-w
An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer
- Rajdeep Das, Martin Sjöström, Raunak Shrestha, …, Alan Ashworth, Felix Y Feng, Luke A Gilbert
- Nat Commun, 10.1038/s41467-021-24919-7