Yeast increases glycolytic flux to support higher growth rates accompanied by decreased metabolite regulation and lower protein phosphorylation
- Min Chen, Tingting Xie, Huan Li, …, Yingping Zhuang, Jianye Xia, Jens Nielsen
- Proc Natl Acad Sci U S A, 10.1073/pnas.2302779120
Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators
- Hong Yang, Xiangyu Li, Han Jin, …, Mathias Uhlén, Jan Borén, Adil Mardinoglu
- Free Radic Biol Med, 10.1016/j.freeradbiomed.2023.05.013
Directed evolution of a wax ester synthase for production of fatty acid ethyl esters in Saccharomyces cerevisiae
- Juan Octavio Valle-RodrÃguez, Verena Siewers, Jens Nielsen, …, Verena Siewers, Jens Nielsen, Shuobo Shi
- Appl Microbiol Biotechnol, 10.1007/s00253-023-12466-8
A highly efficient transcriptome-based biosynthesis of non-ethanol chemicals in Crabtree negative Saccharomyces cerevisiae
- Zhen Yao, Yufeng Guo, Huan Wang, …, Qinhong Wang, Jens Nielsen, Zongjie Dai
- None, 10.1186/s13068-023-02276-5
Self-organized metabotyping of obese individuals identifies clusters responding differently to bariatric surgery
- Dimitra Lappa, Abraham S Meijnikman, Kimberly A Krautkramer, …, Max Nieuwdorp, Fredrik Bäckhed, Jens Nielsen
- PLoS One, 10.1371/journal.pone.0279335
Author Correction: Metabolic reconfiguration enables synthetic reductive metabolism in yeast
- Quanli Liu, Xiang Wang, Xiangjian Liu, …, Xiangjian Liu, Yun Chen, Jens Nielsen
- Nat Metab, 10.1038/s42255-023-00749-3
Generation and analysis of context-specific genome-scale metabolic models derived from single-cell RNA-Seq data
- Johan Gustafsson, Mihail Anton, Fariba Roshanzamir, …, Eduard J Kerkhoven, Jonathan L Robinson, Jens Nielsen
- Proc Natl Acad Sci U S A, 10.1073/pnas.2217868120
COVID-19 mortality attenuated during widespread Omicron transmission, Denmark, 2020 to 2022
- Nikolaj U Friis, Tomas Martin-Bertelsen, Rasmus K Pedersen, …, Tyra G Krause, Viggo Andreasen, Lasse S Vestergaard
- Euro Surveill, 10.2807/1560-7917.es.2023.28.3.2200547
Hospital admissions and need for mechanical ventilation in children with respiratory syncytial virus before and during the COVID-19 pandemic: a Danish nationwide cohort study
- Ulrikka Nygaard, Ulla Birgitte Hartling, Jens Nielsen, …, Astrid Thaarup Matthesen, Kim Kristensen, Mette Holm
- Lancet Child Adolesc Health, 10.1016/s2352-4642(22)00371-6
Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration
- Randi Bonke Mikkelsen, Tulika Arora, Kajetan TroÅ¡t, …, Siv Annegrethe Hjorth, Thue Walter Schwartz, Fredrik Bäckhed
- None, 10.1016/j.isci.2022.105683
Modeling the metabolic dynamics at the genome-scale by optimized yield analysis
- Hao Luo, Peishun Li, Boyang Ji, …, Peishun Li, Boyang Ji, Jens Nielsen
- Metab Eng, 10.1016/j.ymben.2022.12.001
Noninvasive detection of any-stage cancer using free glycosaminoglycans
- Sinisa Bratulic, Angelo Limeta, Saeed Dabestani, …, Eric Jonasch, Jens Nielsen, Francesco Gatto
- Proc Natl Acad Sci U S A, 10.1073/pnas.2115328119
Machine learning for data integration in human gut microbiome
- Peishun Li, Hao Luo, Boyang Ji, Jens Nielsen
- Microb Cell Fact, 10.1186/s12934-022-01973-4
Bioactive metabolites: The double-edged sword in your food
- Jens Nielsen, Jens Nielsen
- Cell, 10.1016/j.cell.2022.10.022
Engineering yeast for high-level production of diterpenoid sclareol
- Xuan Cao, Wei Yu, Yu Chen, …, Jens Nielsen, Hongwei Luan, Yongjin J Zhou
- Metab Eng, 10.1016/j.ymben.2022.11.002
A Pan-Draft Metabolic Model Reflects Evolutionary Diversity across 332 Yeast Species
- Hongzhong Lu, Eduard J Kerkhoven, Jens Nielsen
- Biomolecules, 10.3390/biom12111632
Learning deep representations of enzyme thermal adaptation
- Gang Li, Filip Buric, Jan Zrimec, …, Jens Nielsen, Aleksej Zelezniak, Martin K M Engqvist
- Protein Sci, 10.1002/pro.4480
Protein engineering of invertase for enhancing yeast dough fermentation under high-sucrose conditions
- Yijin Zhao, Kaiwen Meng, Jinyu Fu, …, Jens Nielsen, Zihe Liu, Yueping Zhang
- Folia Microbiol (Praha), 10.1007/s12223-022-01006-y
GotEnzymes: an extensive database of enzyme parameter predictions
- Feiran Li, Yu Chen, Mihail Anton, …, Yu Chen, Mihail Anton, Jens Nielsen
- Nucleic Acids Res, 10.1093/nar/gkac831
Adipose Tissue, Bile Acids, and Gut Microbiome Species Associated With Gallstones After Bariatric Surgery
- M S S Guman, J B Hoozemans, S Haal, …, M Nieuwdorp, A K Groen, V E A Gerdes
- J Lipid Res, 10.1016/j.jlr.2022.100280
Risk of sequelae after invasive meningococcal disease
- Sidsel Skou Voss, Jens Nielsen, Palle Valentiner-Branth
- BMC Infect Dis, 10.1186/s12879-022-07129-4
Expressing a cytosolic pyruvate dehydrogenase complex to increase free fatty acid production in Saccharomyces cerevisiae
- Yiming Zhang, Mo Su, Ning Qin, Jens Nielsen, Zihe Liu
- Microb Cell Fact, 10.1186/s12934-020-01493-z
Compositional and functional differences of the mucosal microbiota along the intestine of healthy individuals
- Stefania Vaga, Sunjae Lee, Boyang Ji, …, Jens Nielsen, Lars Engstrand, Saeed Shoaie
- Sci Rep, 10.1038/s41598-020-71939-2
Promiscuous phosphoketolase and metabolic rewiring enables novel non-oxidative glycolysis in yeast for high-yield production of acetyl-CoA derived products
- John Hellgren, Alexei Godina, Jens Nielsen, Verena Siewers
- Metab Eng, 10.1016/j.ymben.2020.09.003
Integrated Metabolic Modeling, Culturing, and Transcriptomics Explain Enhanced Virulence of Vibrio cholerae during Coinfection with Enterotoxigenic Escherichia coli
- Alyaa M Abdel-Haleem, Vaishnavi Ravikumar, Boyang Ji, …, Jens Nielsen, Takashi Gojobori, Ivan Mijakovic
- mSystems, 10.1128/msystems.00491-20
A systems biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort Study
- C C Van Olden, A W Van de Laar, A S Meijnikman, …, M Nieuwdorp, F Bäckhed, V E A Gerdes
- J Intern Med, 10.1111/joim.13157
Current Status of COVID-19 Therapies and Drug Repositioning Applications
- Ozlem Altay, Elyas Mohammadi, Simon Lam, …, Jens Nielsen, Mathias Uhlen, Adil Mardinoglu
- None, 10.1016/j.isci.2020.101303
Metabolic Engineering of Saccharomyces cerevisiae for Rosmarinic Acid Production
- Mahsa Babaei, Gheorghe M Borja Zamfir, Xiao Chen, …, Mette Kristensen, Jens Nielsen, Irina Borodina
- ACS Synth Biol, 10.1021/acssynbio.0c00048
Improvement in the Current Therapies for Hepatocellular Carcinoma Using a Systems Medicine Approach
- Mehmet Ozcan, Ozlem Altay, Simon Lam, …, Mathias Uhlen, Jan Boren, Adil Mardinoglu
- Adv Biol (Weinh), 10.1002/adbi.202000030
A systems biology approach for studying neurodegenerative diseases
- Simon Lam, Abdulahad Bayraktar, Cheng Zhang, …, Saeed Shoaie, Mathias Uhlen, Adil Mardinoglu
- Drug Discov Today, 10.1016/j.drudis.2020.05.010
Statin therapy is associated with lower prevalence of gut microbiota dysbiosis
- Sara Vieira-Silva, Gwen Falony, Eugeni Belda, …, Fredrik Bäckhed, Karine Clément, Jeroen Raes
- Nature, 10.1038/s41586-020-2269-x
Rewiring carbon flux in Escherichia coli using a bifunctional molecular switch
- Jianshen Hou, Cong Gao, Liang Guo, …, Guipeng Hu, Xiulai Chen, Liming Liu
- Metab Eng, 10.1016/j.ymben.2020.05.004
The role of peroxisomes in xylose alcoholic fermentation in the engineered Saccharomyces cerevisiae
- Ljubov Dzanaeva, Barbara Kruk, Justyna Ruchala, Jens Nielsen, Andriy Sibirny, Kostyantyn Dmytruk
- Cell Biol Int, 10.1002/cbin.11353
Molecular natural history of breast cancer: Leveraging transcriptomics to predict breast cancer progression and aggressiveness
- Daniel J Cook, Jonatan Kallus, Rebecka Jörnsten, Jens Nielsen
- Cancer Med, 10.1002/cam4.2996
Addressing the heterogeneity in liver diseases using biological networks
- Simon Lam, Stephen Doran, Hatice Hilal Yuksel, …, Jan Boren, Mathias Uhlen, Adil Mardinoglu
- Brief Bioinform, 10.1093/bib/bbaa002
Classification of clear cell renal cell carcinoma based on PKM alternative splicing
- Xiangyu Li, Beste Turanli, Kajetan Juszczak, …, Mathias Uhlen, Cheng Zhang, Adil Mardinoglu
- None, 10.1016/j.heliyon.2020.e03440
Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
- Jahir M Gutierrez, Amir Feizi, Shangzhong Li, …, Bernhard O Palsson, Jens Nielsen, Nathan E Lewis
- Nat Commun, 10.1038/s41467-019-13867-y
Impact of sex on diabetic nephropathy and the renal transcriptome in UNx db/db C57BLKS mice
- Frederikke E Sembach, Lisbeth N Fink, Thea Johansen, …, Jacob Jelsing, Tanja X Pedersen, Mette V Østergaard
- Physiol Rep, 10.14814/phy2.14333
Comparative genomics study reveals Red Sea Bacillus with characteristics associated with potential microbial cell factories (MCFs)
- G Othoum, S Prigent, A Derouiche, …, V B Bajic, I Mijakovic, M Essack
- Sci Rep, 10.1038/s41598-019-55726-2
The dorsomedial hypothalamus and nucleus of the solitary tract as key regulators in a rat model of chronic obesity
- Chen Zhang, Pernille Barkholt, Jens Christian Nielsen, …, Niels Vrang, David Paul Drucker Woldbye, Jacob Jelsing
- Brain Res, 10.1016/j.brainres.2019.146538
Comparison of Time to Pregnancy in Women With and Without Inflammatory Bowel Diseases
- Sonia Friedman, Jan Nielsen, Ellen Aagaard Nøhr, Line Riis Jølving, Bente Mertz Nørgård
- Clin Gastroenterol Hepatol, 10.1016/j.cgh.2019.08.031
Intensive screening for osteoporosis in patients with hip fracture
- Anas Ould Si Amar, Lars Hyldstrup, Jette Nielsen, Henrik Palm, Jens-Erik Beck Jensen
- Arch Osteoporos, 10.1007/s11657-019-0612-3
Recent trends in metabolic engineering of microbial chemical factories
- Yi Liu, Jens Nielsen
- Curr Opin Biotechnol, 10.1016/j.copbio.2019.05.010
Proteome analysis of xylose metabolism in Rhodotorula toruloides during lipid production
- Ievgeniia A Tiukova, Jule Brandenburg, Johanna Blomqvist, …, Jens Nielsen, Mats Sandgren, Eduard J Kerkhoven
- None, 10.1186/s13068-019-1478-8
Explaining The Slowdown In Medical Spending Growth Among The Elderly, 1999-2012
- David M Cutler, Kaushik Ghosh, Kassandra L Messer, Trivellore E Raghunathan, Susan T Stewart, Allison B Rosen
- Health Aff (Millwood), 10.1377/hlthaff.2018.05372
Glucose-Dependent Promoters for Dynamic Regulation of Metabolic Pathways
- Jérôme Maury, Soumya Kannan, Niels B Jensen, …, Jens Nielsen, Christopher T Workman, Irina Borodina
- None, 10.3389/fbioe.2018.00063