Inspired by: Gregory Stephanopoulos, James E Bailey
Metabolic engineering is the practice of optimizing genetic and regulatory processes within cells to increase the cell's production of a certain substance. These processes are chemical networks that use a series of biochemical reactions and enzymes that allow cells to convert raw materials into molecules necessary for the cell's survival. Metabolic engineering specifically seeks to mathematically model these networks, calculate a yield of useful products, and pin point parts of the network that constrain the production of these products. Wikipedia (CC BY-SA 3.0)
📺 Subchannels:
- Precision fermentation
- Metabolic engineering of methanol as a feedstock
- Metabolic engineering of Vibrio natriegens
2023 Articles
3 255 articles
Sensitivity Analysis of Genome-Scale Metabolic Flux Prediction
- Puhua Niu, Maria J Soto, Shuai Huang, …, Francis J Alexander, Ian Blaby, Xiaoning Qian
- J Comput Biol, 10.1089/cmb.2022.0368
Gene Deletion Algorithms for Minimum Reaction Network Design by Mixed-Integer Linear Programming for Metabolite Production in Constraint-Based Models: gDel_minRN
- Takeyuki Tamura, Ai Muto-Fujita, Yukako Tohsato, …, Ai Muto-Fujita, Yukako Tohsato, Tomoyuki Kosaka
- J Comput Biol, 10.1089/cmb.2022.0352
Simulated Design-Build-Test-Learn Cycles for Consistent Comparison of Machine Learning Methods in Metabolic Engineering
- Paul van Lent, Joep Schmitz, Thomas Abeel
- ACS Synth Biol, 10.1021/acssynbio.3c00186
Engineering of increased L-Threonine production in bacteria by combinatorial cloning and machine learning
- Paul Hanke, Bruce Parrello, Olga Vasieva, …, Dionysios Antonopoulos, Rick Stevens, Michael Fonstein
- Metab Eng, 10.1016/j.mec.2023.e00225
Bayesian Optimization for Design of Multiscale Biological Circuits
- Charlotte Merzbacher, Oisin Mac Aodha, Diego A Oyarzún, …, Charlotte Merzbacher, Oisin Mac Aodha, Diego A Oyarzún
- ACS Synth Biol, 10.1021/acssynbio.3c00120
Current advancements in systems and synthetic biology studies of Saccharomyces cerevisiae
- Tiew-Yik Ting, YaDong Li, Hamidun Bunawan, …, Hamidun Bunawan, Ahmad Bazli Ramzi, Hoe-Han Goh
- J Biosci Bioeng, 10.1016/j.jbiosc.2023.01.010
Minireview: Engineering evolution to reconfigure phenotypic traits in microbes for biotechnological applications
- Kangsan Kim, Minjeong Kang, Sang-Hyeok Cho, …, Suhyung Cho, Bernhard Palsson, Byung-Kwan Cho
- None, 10.1016/j.csbj.2022.12.042
Metabolic engineering for sustainability and health
- Gi Bae Kim, So Young Choi, In Jin Cho, …, In Jin Cho, Da-Hee Ahn, Sang Yup Lee
- Trends Biotechnol, 10.1016/j.tibtech.2022.12.014
Modular Metabolic Engineering and Synthetic Coculture Strategies for the Production of Aromatic Compounds in Yeast
- Huadong Peng, Ruiqi Chen, William M Shaw, …, David J Bell, Tom Ellis, Rodrigo Ledesma-Amaro
- ACS Synth Biol, 10.1021/acssynbio.3c00047
Highlighting the potential of Synechococcus elongatus PCC 7942 as platform to produce α-linolenic acid through an updated genome-scale metabolic modeling
- María Santos-Merino, Álvaro Gargantilla-Becerra, Fernando de la Cruz, …, Álvaro Gargantilla-Becerra, Fernando de la Cruz, Juan Nogales
- None, 10.3389/fmicb.2023.1126030
2022 Articles
329 articles
Machine learning-guided prediction of potential engineering targets for microbial production of lycopene
- Chang Keun Kang, Jihoon Shin, YoonKyung Cha, …, TaeHo Kim, Young-Kwon Park, Yong Jun Choi
- Bioresour Technol, 10.1016/j.biortech.2022.128455
Combinatorial library design for improving isobutanol production in Saccharomyces cerevisiae
- Francesca V Gambacorta, Joshua J Dietrich, Justin J Baerwald, …, Stephanie J Brown, Yun Su, Brian F Pfleger
- None, 10.3389/fbioe.2022.1080024
Metabolic Engineering: Methodologies and Applications
- Michael J Volk, Vinh G Tran, Shih-I Tan, …, Pu Xue, Teresa A Martin, Huimin Zhao
- Chem Rev, 10.1021/acs.chemrev.2c00403
Modeling the metabolic dynamics at the genome-scale by optimized yield analysis
- Hao Luo, Peishun Li, Boyang Ji, …, Peishun Li, Boyang Ji, Jens Nielsen
- Metab Eng, 10.1016/j.ymben.2022.12.001
Accuracy and data efficiency in deep learning models of protein expression
- Evangelos-Marios Nikolados, Arin Wongprommoon, Oisin Mac Aodha, …, Oisin Mac Aodha, Guillaume Cambray, Diego A Oyarzún
- Nat Commun, 10.1038/s41467-022-34902-5
Rapid prototyping enzyme homologs to improve titer of nicotinamide mononucleotide using a strategy combining cell-free protein synthesis with split GFP
- Qingyan Yuan, Minhui Wu, Yibo Liao, …, Shuli Liang, Yuan Lu, Ying Lin
- Biotechnol Bioeng, 10.1002/bit.28326
Engineering isoprenoids production in metabolically versatile microbial host Pseudomonas putida
- Xi Wang, Edward E K Baidoo, Ramu Kakumanu, …, Silvia Xie, Aindrila Mukhopadhyay, Taek Soon Lee
- None, 10.1186/s13068-022-02235-6
Genetically encoded biosensors for microbial synthetic biology: From conceptual frameworks to practical applications
- Wenwen Yu, Xianhao Xu, Ke Jin, …, Guocheng Du, Xueqin Lv, Long Liu
- Biotechnol Adv, 10.1016/j.biotechadv.2022.108077
Metabolic engineering of Corynebacterium glutamicum for l-tyrosine production from glucose and xylose
- Eldin Kurpejović, Arthur Burgardt, Gülsüm Merve Bastem, …, Nora Junker, Volker F Wendisch, Berna Sariyar Akbulut
- J Biotechnol, 10.1016/j.jbiotec.2022.12.005
Developing Cyanobacterial Quorum Sensing Toolkits: Toward Interspecies Coordination in Mixed Autotroph/Heterotroph Communities
- Emmanuel J Kokarakis, Rees Rillema, Daniel C Ducat, …, Rees Rillema, Daniel C Ducat, Jonathan K Sakkos
- ACS Synth Biol, 10.1021/acssynbio.2c00527