MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme
- Yingzhong Li, Nikola A Ivica, Ting Dong, …, Paula T Hammond, Matthew G Vander Heiden, Jianzhu Chen
- Nat Commun, 10.1038/s41467-020-18607-1
A PEROXO-Tag Enables Rapid Isolation of Peroxisomes from Human Cells
- G Jordan Ray, Elizabeth A Boydston, Emily Shortt, …, Sebastian Lourido, Walter W Chen, David M Sabatini
- None, 10.1016/j.isci.2020.101109
MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo
- Erol C Bayraktar, Lou Baudrier, Ceren Özerdem, …, David M Sabatini, Kıvanç Birsoy, Walter W Chen
- Proc Natl Acad Sci U S A, 10.1073/pnas.1816656115
Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites
- Walter W Chen, Elizaveta Freinkman, David M Sabatini
- Nat Protoc, 10.1038/nprot.2017.104
mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient
- Gregory A Wyant, Monther Abu-Remaileh, Rachel L Wolfson, …, Laura V Danai, Matthew G Vander Heiden, David M Sabatini
- Cell, 10.1016/j.cell.2017.09.046
Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras
- Tim Wang, Haiyan Yu, Nicholas W Hughes, …, Walter W Chen, Eric S Lander, David M Sabatini
- Cell, 10.1016/j.cell.2017.01.013
Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism
- Walter W Chen, Elizaveta Freinkman, Tim Wang, Kıvanç Birsoy, David M Sabatini
- Cell, 10.1016/j.cell.2016.07.040
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate
- Michael E Pacold, Kyle R Brimacombe, Sze Ham Chan, …, Nathanael S Gray, Matthew B Boxer, David M Sabatini
- Nat Chem Biol, 10.1038/nchembio.2070
An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis
- Kıvanç Birsoy, Tim Wang, Walter W Chen, Elizaveta Freinkman, Monther Abu-Remaileh, David M Sabatini
- Cell, 10.1016/j.cell.2015.07.016
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
- Dohoon Kim, Brian P Fiske, Kivanc Birsoy, …, Matija Snuderl, Matthew G Vander Heiden, David M Sabatini
- Nature, 10.1038/nature14363
Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness
- Pekka Katajisto, Julia Döhla, Christine L Chaffer, …, Walter Chen, Robert A Weinberg, David M Sabatini
- Science, 10.1126/science.1260384
Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition
- Yoav D Shaul, Elizaveta Freinkman, William C Comb, …, Robert A Weinberg, Michael B Yaffe, David M Sabatini
- Cell, 10.1016/j.cell.2014.07.032
Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells
- Walter W Chen, Kivanc Birsoy, Maria M Mihaylova, …, Thijn R Brummelkamp, David D Sabatini, David M Sabatini
- Cell Rep, 10.1016/j.celrep.2014.02.046
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
- Kıvanç Birsoy, Richard Possemato, Franziska K Lorbeer, …, Walter W Chen, Clary B Clish, David M Sabatini
- Nature, 10.1038/nature13110
BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles
- Walter W Chen, Leonora Balaj, Linda M Liau, …, Fred H Hochberg, Xandra O Breakefield, Johan Skog
- None, 10.1038/mtna.2013.28
MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors
- Kivanç Birsoy, Tim Wang, Richard Possemato, …, Thijn R Brummelkamp, Clary B Clish, David M Sabatini
- Nat Genet, 10.1038/ng.2471
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
- Richard Possemato, Kevin M Marks, Yoav D Shaul, …, Elena F Brachtel, Edward M Driggers, David M Sabatini
- Nature, 10.1038/nature10350