Bioconjugate Platform for Iterative Backbone N -Methylation of Peptides
- Yiwu Zheng, Chayanid Ongpipattanakul, Satish K Nair, …, Yiwu Zheng, Chayanid Ongpipattanakul, Satish K Nair
- None, 10.1021/acscatal.2c04681
Mutational fitness landscape of human influenza H3N2 neuraminidase
- Ruipeng Lei, Andrea Hernandez Garcia, Timothy J C Tan, …, Satish K Nair, Jian Peng, Nicholas C Wu
- Cell Rep, 10.1016/j.celrep.2022.111951
The mechanism of thia-Michael addition catalyzed by LanC enzymes
- Chayanid Ongpipattanakul, Shi Liu, Youran Luo, …, Youran Luo, Satish K Nair, Wilfred A van der Donk
- Proc Natl Acad Sci U S A, 10.1073/pnas.2217523120
Designer installation of a substrate recruitment domain to tailor enzyme specificity
- Rodney Park, Chayanid Ongpipattanakul, Satish K Nair, …, Satish K Nair, Albert A Bowers, Brian Kuhlman
- Nat Chem Biol, 10.1038/s41589-022-01206-0
Enzymatic Pyridine Aromatization during Thiopeptide Biosynthesis
- Andrew J Rice, Jarrett M Pelton, Nicholas J Kramer, …, Taras V Pogorelov, Douglas A Mitchell, Albert A Bowers
- J Am Chem Soc, 10.1021/jacs.2c07377
Prevalence and mechanisms of evolutionary contingency in human influenza H3N2 neuraminidase
- Ruipeng Lei, Timothy J C Tan, Andrea Hernandez Garcia, …, Christopher B Brooke, Satish K Nair, Nicholas C Wu
- Nat Commun, 10.1038/s41467-022-34060-8
YcaO-mediated ATP-dependent peptidase activity in ribosomal peptide biosynthesis
- Yiwu Zheng, Yiwu Zheng, Yiwu Zheng, …, Satish K Nair, Yiwu Zheng, Satish K Nair
- Nat Chem Biol, 10.1038/s41589-022-01141-0
Convergent and divergent biosynthetic strategies towards phosphonic acid natural products
- Kou-San Ju, Satish K Nair, Kou-San Ju, Satish K Nair, Kou-San Ju, Satish K Nair
- Curr Opin Chem Biol, 10.1016/j.cbpa.2022.102214
Class V Lanthipeptide Cyclase Directs the Biosynthesis of a Stapled Peptide Natural Product
- Zeng-Fei Pei, Lingyang Zhu, Raymond Sarksian, …, Raymond Sarksian, Wilfred A van der Donk, Satish K Nair
- J Am Chem Soc, 10.1021/jacs.2c06808
Mechanism of Action of Ribosomally Synthesized and Post-Translationally Modified Peptides
- Chayanid Ongpipattanakul, Emily K Desormeaux, Adam DiCaprio, …, Wilfred A van der Donk, Douglas A Mitchell, Satish K Nair
- Chem Rev, 10.1021/acs.chemrev.2c00210
Catalysts for the Enzymatic Lipidation of Peptides
- Yiwu Zheng, Ying Cong, Eric W Schmidt, Satish K Nair
- Acc Chem Res, 10.1021/acs.accounts.2c00108
Control of Nucleophile Chemoselectivity in Cyanobactin YcaO Heterocyclases PatD and TruD
- Wenjia Gu, Yiwu Zheng, Taras Pogorelov, …, Taras Pogorelov, Satish K Nair, Eric W Schmidt
- ACS Chem Biol, 10.1021/acschembio.2c00147
Structure and mechanism for iterative amide N -methylation in the biosynthesis of channel-forming peptide cytotoxins
- Dillon P Cogan, Agneya Bhushan, Reyvin Reyes, Lingyang Zhu, Jörn Piel, Satish K Nair
- Proc Natl Acad Sci U S A, 10.1073/pnas.2116578119
Structural and mechanistic investigations of protein S-glycosyltransferases
- Daisuke Fujinami, Chantal V Garcia de Gonzalo, Subhanip Biswas, …, Tiit Lukk, Satish K Nair, Wilfred A van der Donk
- Cell Chem Biol, 10.1016/j.chembiol.2021.06.009
Identification and characterization of andalusicin: N-terminally dimethylated class III lantibiotic from Bacillus thuringiensis sv. andalousiensis
- Anastasiia Grigoreva, Julia Andreeva, Dmitry Bikmetov, …, Guy Lippens, Konstantin Severinov, Svetlana Dubiley
- None, 10.1016/j.isci.2021.102480
Biosynthesis of fosfomycin in pseudomonads reveals an unexpected enzymatic activity in the metallohydrolase superfamily
- Max A Simon, Chayanid Ongpipattanakul, Satish K Nair, Wilfred A van der Donk
- Proc Natl Acad Sci U S A, 10.1073/pnas.2019863118
LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome
- Kuan-Yu Lai, Sébastien R G Galan, Yibo Zeng, …, Jie Chen, Benjamin G Davis, Wilfred A van der Donk
- Cell, 10.1016/j.cell.2021.04.001