A screen for MeCP2-TBL1 interaction inhibitors using a luminescence-based assay
- Beatrice Alexander-Howden, Li Zhang, Almer M van der Sloot, …, Adrian P Bird, Mike Tyers, Matthew J Lyst
- Sci Rep, 10.1038/s41598-023-29915-z
Overview of the COVID-19 text mining tool interactive demonstration track in BioCreative VII
- Andrew Chatr-Aryamontri, Lynette Hirschman, Karen E Ross, …, Mike Tyers, Tonia Korves, Cecilia N Arighi
- Database (Oxford), 10.1093/database/baac084
Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4
- Chetan K Chana, Pierre Maisonneuve, Ganna Posternak, …, Mikko Taipale, Anne-Claude Gingras, Frank Sicheri
- J Med Chem, 10.1021/acs.jmedchem.2c00509
Head-to-tail cyclization of side chain-protected linear peptides to recapitulate genetically-encoded cyclized peptides
- Samir Bouayad-Gervais, Daniel J St-Cyr, Mathieu Courcelles, …, Pierre Thibault, William C Earnshaw, Mike Tyers
- None, 10.1002/pep2.24254
Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion
- Sylvain Tollis, Andrea Rizzotto, Nhan T Pham, …, Manfred Auer, Mike Tyers, Eric C Schirmer
- ACS Chem Biol, 10.1021/acschembio.2c00004
Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia
- Jana Krosl, Marie-Eve Bordeleau, Céline Moison, …, Anne Marinier, Josée Hébert, Guy Sauvageau
- Blood Adv, 10.1182/bloodadvances.2021006047
Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells
- Punit Saraon, Jamie Snider, Wiebke Schormann, …, David Andrews, Rima Al-Awar, Igor Stagljar
- J Mol Biol, 10.1016/j.jmb.2021.167294
A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells
- Muhammad Sohail, Lulzim Shkreta, Johanne Toutant, …, Mike Tyers, David S Grierson, Benoit Chabot
- Nucleic Acids Res, 10.1093/narcan/zcab019
A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition
- Yahya Benslimane, MarÃa Sánchez-Osuna, Jasmin Coulombe-Huntington, …, Pierre Thibault, Mike Tyers, Lea Harrington
- Aging Cell, 10.1111/acel.13331
UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex
- Jalila Chagraoui, Simon Girard, Jean-Francois Spinella, …, Mike Tyers, Anne Marinier, Guy Sauvageau
- Cell Stem Cell, 10.1016/j.stem.2020.12.002
The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions
- Rose Oughtred, Jennifer Rust, Christie Chang, …, Andrew Chatr-Aryamontri, Kara Dolinski, Mike Tyers
- Protein Sci, 10.1002/pro.3978
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
- Fred D Mast, Arti T Navare, Almer M van der Sloot, …, Andrej Sali, Mike Tyers, John D Aitchison
- J Cell Biol, 10.1083/jcb.202006159
Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells
- Yahya Benslimane, Thierry Bertomeu, Jasmin Coulombe-Huntington, …, Hugo Wurtele, Mike Tyers, Lea Harrington
- Mol Cell, 10.1016/j.molcel.2020.07.010
G1/S transcription factors assemble in increasing numbers of discrete clusters through G1 phase
- Labe Black, Sylvain Tollis, Guo Fu, …, Marcelo Nollmann, Mike Tyers, Catherine Ann Royer
- J Cell Biol, 10.1083/jcb.202003041
Author Correction: Caenorhabditis elegans is a useful model for anthelmintic discovery
- Andrew R Burns, Genna M Luciani, Gabriel Musso, …, Calum A MacRae, John Gilleard, Peter J Roy
- Nat Commun, 10.1038/s41467-020-17617-3
Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response
- Magdalena M Szewczyk, Yoshinori Ishikawa, Shawna Organ, …, Peter J Brown, Hiroshi Nara, Dalia Barsyte-Lovejoy
- Nat Commun, 10.1038/s41467-020-16613-x
Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma
- Kulandaimanuvel Antony Michealraj, Sachin A Kumar, Leo J Y Kim, …, Sameer Agnihotri, Jeremy N Rich, Michael D Taylor
- Cell, 10.1016/j.cell.2020.04.047
Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development
- Samuel Jacques, Almer M van der Sloot, Caroline C Huard, …, Pierre Thibault, Gerard D Wright, Mike Tyers
- Genetics, 10.1534/genetics.119.302851
Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways
- Spencer Hill, Kurt Reichermeier, Daniel C Scott, …, Frank Sicheri, Mike Tyers, Gary Kleiger
- Elife, 10.7554/elife.51163
Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia
- Irène Baccelli, Yves Gareau, Bernhard Lehnertz, …, Josée Hébert, Anne Marinier, Guy Sauvageau
- Cancer Cell, 10.1016/j.ccell.2019.06.003
Gene Information eXtension (GIX): effortless retrieval of gene product information on any website
- James D R Knight, Payman Samavarchi-Tehrani, Mike Tyers, Anne-Claude Gingras
- Nat Methods, 10.1038/s41592-019-0477-9
The p38/HOG stress-activated protein kinase network couples growth to division in Candida albicans
- Adnane Sellam, Julien Chaillot, Jaideep Mallick, …, Julien Richard Albert, Michael A Cook, Mike Tyers
- PLoS Genet, 10.1371/journal.pgen.1008052
Drug combinations: a strategy to extend the life of antibiotics in the 21st century
- Mike Tyers, Gerard D Wright
- Nat Rev Microbiol, 10.1038/s41579-018-0141-x
Proteome-wide, Structure-Based Prediction of Protein-Protein Interactions/New Molecular Interactions Viewer
- Shaowei Dong, Vincent Lau, Richard Song, …, Ruth Grene, Björn Usadel, Nicholas J Provart
- Plant Physiol, 10.1104/pp.18.01216
The BioGRID interaction database: 2019 update
- Rose Oughtred, Chris Stark, Bobby-Joe Breitkreutz, …, Andrew Chatr-Aryamontri, Kara Dolinski, Mike Tyers
- Nucleic Acids Res, 10.1093/nar/gky1079
Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay
- Joanna Koszela, Nhan T Pham, David Evans, …, Frank Sicheri, Mike Tyers, Manfred Auer
- BMC Biol, 10.1186/s12915-018-0554-z
Combined Enrichment/Enzymatic Approach To Study Tightly Clustered Multisite Phosphorylation on Ser-Rich Domains
- Evgeny Kanshin, Mirela Pascariu, Mike Tyers, Damien D’Amours, Pierre Thibault
- J Proteome Res, 10.1021/acs.jproteome.8b00205
Condensin ATPase motifs contribute differentially to the maintenance of chromosome morphology and genome stability
- Roger Palou, Thillaivillalan Dhanaraman, Rim Marrakchi, Mirela Pascariu, Mike Tyers, Damien D’Amours
- PLoS Biol, 10.1371/journal.pbio.2003980
G1/S Transcription Factor Copy Number Is a Growth-Dependent Determinant of Cell Cycle Commitment in Yeast
- Savanna Dorsey, Sylvain Tollis, Jing Cheng, …, Stephen Notley, Mike Tyers, Catherine A Royer
- Cell Syst, 10.1016/j.cels.2018.04.012
At Long Last, a C-Terminal Bookend for the Ubiquitin Code
- Andrew Chatr-Aryamontri, Almer van der Sloot, Mike Tyers
- Mol Cell, 10.1016/j.molcel.2018.05.006