Video highlight
MSBooster: improving peptide identification rates using deep learning-based features
- Kevin L Yang, Guo Ci Teo, Kai Li, …, Vadim Demichev, Markus Ralser, Alexey I Nesvizhskii
- Nat Commun, 10.1038/s41467-023-40129-9
Spontaneously established syntrophic yeast communities improve bioproduction
- Simran Kaur Aulakh, Lara Sellés Vidal, Eric J South, …, Lucia Herrera-Dominguez, Markus Ralser, Rodrigo Ledesma-Amaro
- Nat Chem Biol, 10.1038/s41589-023-01341-2
The proteomic landscape of genome-wide genetic perturbations
- Christoph B Messner, Vadim Demichev, Julia Muenzner, …, Charles Boone, Georg Kustatscher, Markus Ralser
- Cell, 10.1016/j.cell.2023.03.026
Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
- Callum Jackson, Iain D Stewart, Tatiana Plekhanova, …, Samuel E Jones, Martin K Rutter, John F Blaikley
- Lancet Respir Med, 10.1016/s2213-2600(23)00124-8
RECAST: Study protocol for an observational study for the understanding of the increased REsilience of Children compared to Adults in SARS-CoV-2 infecTion
- Sebastian Stricker, Niklas Ziegahn, Martin Karsten, …, Marcus A Mall, Birgit Sawitzki, Jobst Roehmel
- BMJ Open, 10.1136/bmjopen-2022-065221
The GAPDH redox switch safeguards reductive capacity and enables survival of stressed tumour cells
- Deepti Talwar, Colin G Miller, Justus Grossmann, …, Michael Mülleder, Markus Ralser, Tobias P Dick
- Nat Metab, 10.1038/s42255-023-00781-3
Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study
- Hamish J C McAuley, Rachael A Evans, Charlotte E Bolton, …, Miles D Witham, Janet Lord, Neil J Greening
- None, 10.1016/j.eclinm.2023.101896
Quantitative protein biomarker panels: a path to improved clinical practice through proteomics
- Johannes Hartl, Florian Kurth, Kai Kappert, …, Michael Mülleder, Gunther Hartmann, Markus Ralser
- EMBO Mol Med, 10.15252/emmm.202216061
The brain reacting to COVID-19: analysis of the cerebrospinal fluid proteome, RNA and inflammation
- Dirk Reinhold, Vadim Farztdinov, Yan Yan, …, Michael Mülleder, Frank Heppner, Peter Körtvelyessy
- J Neuroinflammation, 10.1186/s12974-023-02711-2
Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan
- Clara Correia-Melo, Stephan Kamrad, Roland Tengölics, …, Balázs Papp, Mohammad Tauqeer Alam, Markus Ralser
- Cell, 10.1016/j.cell.2022.12.007
Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumonia
- Iker Valle Aramburu, Dennis Hoving, Spyros I Vernardis, …, Florian Kurth, Markus Ralser, Venizelos Papayannopoulos
- Immunity, 10.1016/j.immuni.2022.11.007
High-throughput proteomics of nanogram-scale samples with Zeno SWATH MS
- Ziyue Wang, Michael Mülleder, Ihor Batruch, …, Vadim Demichev, Stephen Tate, Markus Ralser
- Elife, 10.7554/elife.83947
N6 -methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast
- Radhika A Varier, Theodora Sideri, Charlotte Capitanchik, …, Jernej Ule, Nicholas M Luscombe, Folkert J van Werven
- Elife, 10.7554/elife.84034
Synthetic metabolism without the TCA cycle
- Steffen N Lindner, Steffen N Lindner, Markus Ralser
- Nat Metab, 10.1038/s42255-022-00668-9
Metal ion availability and homeostasis as drivers of metabolic evolution and enzyme function
- Simran Kaur Aulakh, Sreejith Jayasree Varma, Markus Ralser, …, Simran Kaur Aulakh, Sreejith Jayasree Varma, Markus Ralser
- Curr Opin Genet Dev, 10.1016/j.gde.2022.101987
The human host response to monkeypox infection: a proteomic case series study
- Ziyue Wang, Pinkus Tober-Lau, Vadim Farztdinov, …, Michael Mülleder, Markus Ralser, Florian Kurth
- EMBO Mol Med, 10.15252/emmm.202216643
Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake in mice
- Catalina Cosovanu, Philipp Resch, Stefan Jordan, …, Michael Mülleder, Sebastian Brachs, Christian Neumann
- J Exp Med, 10.1084/jem.20220233
Cystatin C is associated with adverse COVID-19 outcomes in diverse populations
- Sam O Kleeman, Mattia Cordioli, Paul R H J Timmers, …, Andrea Ganna, Kenneth Baillie, Tobias Janowitz
- None, 10.1016/j.isci.2022.105040
Integration of protein context improves protein-based COVID-19 patient stratification
- Jinlong Gao, Jiale He, Fangfei Zhang, …, Markus Ralser, Tiannan Guo, Yi Zhu
- None, 10.1186/s12014-022-09370-0
Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening
- Marianna Ioannou, Dennis Hoving, Iker Valle Aramburu, …, Klaus Stahl, Christian Bode, Venizelos Papayannopoulos
- Nat Commun, 10.1038/s41467-022-32320-1
Global analysis of cytosine and adenine DNA modifications across the tree of life
- Sreejith Jayasree Varma, Enrica Calvani, Nana-Maria Grüning, …, Floriana Capuano, Michael Mülleder, Markus Ralser
- Elife, 10.7554/elife.81002
Increasing the throughput of sensitive proteomics by plexDIA
- Andrew Leduc, Georg Wallmann, R Gray Huffman, …, Markus Ralser, Vadim Demichev, Nikolai Slavov
- Nat Biotechnol, 10.1038/s41587-022-01389-w
Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study
- Rachael A Evans, Hamish McAuley, Ewen M Harrison, …, Krisnah Poinasamy, Louise V Wain, Christopher E Brightling
- Lancet Respir Med, 10.1016/s2213-2600(21)00383-0
Time-resolved in vivo ubiquitinome profiling by DIA-MS reveals USP7 targets on a proteome-wide scale
- Martin Steger, Vadim Demichev, Mattias Backman, …, Stefan Müller, Markus Ralser, Henrik Daub
- Nat Commun, 10.1038/s41467-021-25454-1
Virus-induced senescence is a driver and therapeutic target in COVID-19
- Soyoung Lee, Yong Yu, Jakob Trimpert, …, Maurice Reimann, Dorothy N Y Fan, Clemens A Schmitt
- Nature, 10.1038/s41586-021-03995-1
Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19
- Geraldine Nouailles, Emanuel Wyler, Peter Pennitz, …, Markus Landthaler, Jakob Trimpert, Martin Witzenrath
- Nat Commun, 10.1038/s41467-021-25030-7
A serum proteome signature to predict mortality in severe COVID-19 patients
- Franziska Völlmy, Henk van den Toorn, Riccardo Zenezini Chiozzi, …, Savino Spadaro, Paola Rizzo, Albert Jr Heck
- Life Sci Alliance, 10.26508/lsa.202101099
SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells
- Yogesh Singh, Christoph Trautwein, Rolf Fendel, …, Madhuri S Salker, Nicolas Casadei, Olaf Riess
- None, 10.1016/j.heliyon.2021.e07147
Swarm Learning for decentralized and confidential clinical machine learning
- Stefanie Warnat-Herresthal, Hartmut Schultze, Krishnaprasad Lingadahalli Shastry, …, Michael S Woodacre, Eng Lim Goh, Joachim L Schultze
- Nature, 10.1038/s41586-021-03583-3
Author Correction: Genetic architecture of host proteins involved in SARS-CoV-2 infection
- Maik Pietzner, Eleanor Wheeler, Julia Carrasco-Zanini, …, Nicholas J Wareham, Aroon D Hingorani, Claudia Langenberg
- Nat Commun, 10.1038/s41467-021-21370-6
Absence of blood parasites and other vector-borne pathogens in Alpine marmots (Marmota marmota) in Western Austria
- Hans-Peter Fuehrer, Ilona Soukup, Bita Shahi-Barogh, Walter Glawischnig
- Parasitol Res, 10.1007/s00436-020-07006-6
Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast
- Angela Rubio, Sanjay Ghosh, Michael Mülleder, Markus Ralser, Juan Mata
- Nucleic Acids Res, 10.1093/nar/gkaa1180
Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19
- Joana P Bernardes, Neha Mishra, Florian Tran, …, Stefan Schreiber, Joachim L Schultze, Philip Rosenstiel
- Immunity, 10.1016/j.immuni.2020.11.017
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment
- Jonas Schulte-Schrepping, Nico Reusch, Daniela Paclik, …, Birgit Sawitzki, Antoine-Emmanuel Saliba, Leif Erik Sander
- Cell, 10.1016/j.cell.2020.08.001
The next decade of metabolism
- Fredrik Bäckhed, Elisabetta Bugianesi, Heather Christofk, …, Markus Ralser, David M Sabatini, Matthias Tschöp
- Nat Metab, 10.1038/s42255-018-0022-7
Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection
- Christoph B Messner, Vadim Demichev, Daniel Wendisch, …, Florian Kurth, Leif Erik Sander, Markus Ralser
- Cell Syst, 10.1016/j.cels.2020.05.012
DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput
- Vadim Demichev, Christoph B Messner, Spyros I Vernardis, Kathryn S Lilley, Markus Ralser
- Nat Methods, 10.1038/s41592-019-0638-x
Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase deficiency
- Joanna Segal, Michael Mülleder, Antje Krüger, …, Heinrich Schrewe, Mariia Yuneva, Markus Ralser
- J Inherit Metab Dis, 10.1002/jimd.12105
Cost-effective generation of precise label-free quantitative proteomes in high-throughput by microLC and data-independent acquisition
- Jakob Vowinckel, Aleksej Zelezniak, Roland Bruderer, Michael Mülleder, Lukas Reiter, Markus Ralser
- Sci Rep, 10.1038/s41598-018-22610-4
