Scholar: Lauren Lebon

Lauren Lebon

eIF2B activator prevents neurological defects caused by a chronic integrated stress response

  • Yao Liang Wong, Lauren LeBon, Ana M Basso, …, Kathleen Martin, Michael J Dart, Carmela Sidrauski
  • Elife, 10.7554/elife.42940
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The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes

  • Yao Liang Wong, Lauren LeBon, Rohinton Edalji, Hock Ben Lim, Chaohong Sun, Carmela Sidrauski
  • Elife, 10.7554/elife.32733
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Dynamic Ligand Discrimination in the Notch Signaling Pathway

  • Nagarajan Nandagopal, Leah A Santat, Lauren LeBon, David Sprinzak, Marianne E Bronner, Michael B Elowitz
  • Cell, 10.1016/j.cell.2018.01.002
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Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states

  • Lauren LeBon, Tom V Lee, David Sprinzak, Hamed Jafar-Nejad, Michael B Elowitz
  • Elife, 10.7554/elife.02950
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Mutual inactivation of Notch receptors and ligands facilitates developmental patterning

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Cis-interactions between Notch and Delta generate mutually exclusive signalling states

  • David Sprinzak, Amit Lakhanpal, Lauren Lebon, …, Graham A Anderson, Jordi Garcia-Ojalvo, Michael B Elowitz
  • Nature, 10.1038/nature08959
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