Chemical Biology Approaches to Identify and Profile Interactors of Chromatin Modifications
- Garrison A Nickel, Katharine L Diehl, Garrison A Nickel, …, Katharine L Diehl, Garrison A Nickel, Katharine L Diehl
- ACS Chem Biol, 10.1021/acschembio.1c00794
Chromatin as a key consumer in the metabolite economy
- Katharine L Diehl, Tom W Muir
- Nat Chem Biol, 10.1038/s41589-020-0517-x
PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor
- Katharine L Diehl, Eva J Ge, Daniel N Weinberg, Krupa S Jani, C David Allis, Tom W Muir
- Proc Natl Acad Sci U S A, 10.1073/pnas.1911775116
Nucleation and Propagation of Heterochromatin by the Histone Methyltransferase PRC2: Geometric Constraints and Impact of the Regulatory Subunit JARID2
- Eva J Ge, Krupa S Jani, Katharine L Diehl, Manuel M Müller, Tom W Muir
- J Am Chem Soc, 10.1021/jacs.9b02321
PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism
- Siddhant U Jain, Truman J Do, Peder J Lund, …, Benjamin A Garcia, Nada Jabado, Peter W Lewis
- Nat Commun, 10.1038/s41467-019-09981-6
Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase
- Krupa S Jani, Siddhant U Jain, Eva J Ge, …, Manuel M Müller, Peter W Lewis, Tom W Muir
- Proc Natl Acad Sci U S A, 10.1073/pnas.1819029116
ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference
- Geoffrey P Dann, Glen P Liszczak, John D Bagert, …, Katharine L Diehl, C David Allis, Tom W Muir
- Nature, 10.1038/nature23671
Array sensing using optical methods for detection of chemical and biological hazards
- Katharine L Diehl, Eric V Anslyn
- Chem Soc Rev, 10.1039/c3cs60136f