Scholar: Issam Ben-Sahra

Issam Ben-Sahra

Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production

  • Ella N Perrault, Jack M Shireman, Eunus S Ali, …, Anindita Basu, Jason Miska, Atique U Ahmed
  • Sci Adv, 10.1126/sciadv.ade7236
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Longitudinal trajectories of branched chain amino acids through young adulthood and diabetes in later life

  • Konrad T Sawicki, Hongyan Ning, Norrina B Allen, …, Elizabeth M McNally, Janet K Snell-Bergeon, John T Wilkins
  • JCI Insight, 10.1172/jci.insight.166956
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Regulation of nucleotide metabolism in cancers and immune disorders

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The cell cycle loops UTP around CAD

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Purine synthesis suppression reduces the development and progression of pulmonary hypertension in rodent models

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GATOR2 rings GATOR1 to speak to mTORC1

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Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia

  • Qi Jin, Blanca Gutierrez Diaz, Tim Pieters, …, John D Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos
  • Sci Adv, 10.1126/sciadv.abq8437
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ATIC-Associated De Novo Purine Synthesis Is Critically Involved in Proliferative Arterial Disease

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C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways

  • David R Amici, Daniel J Ansel, Kyle A Metz, …, Daniel R Foltz, Jian Li, Marc L Mendillo
  • Proc Natl Acad Sci U S A, 10.1073/pnas.2111262119
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The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis

  • Eunus S Ali, Anna LipoÅ„ska, Brendan P O’Hara, …, Mee-Ngan F Yap, Marc L Mendillo, Issam Ben-Sahra
  • Mol Cell, 10.1016/j.molcel.2022.06.008
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ZFP36L2 suppresses mTORc1 through a P53-dependent pathway to prevent peripartum cardiomyopathy in mice

  • Hidemichi Kouzu, Yuki Tatekoshi, Hsiang-Chun Chang, …, Chunlei Chen, Perry J Blackshear, Hossein Ardehali
  • J Clin Invest, 10.1172/jci154491
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