Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production
- Eunus S Ali
- Issam Ben-Sahra
- May 17, 2023
- kedalionlabs.com
- Ella N Perrault, Jack M Shireman, Eunus S Ali, …, Anindita Basu, Jason Miska, Atique U Ahmed
- Sci Adv, 10.1126/sciadv.ade7236
Longitudinal trajectories of branched chain amino acids through young adulthood and diabetes in later life
- Issam Ben-Sahra
- April 24, 2023
- kedalionlabs.com
- Konrad T Sawicki, Hongyan Ning, Norrina B Allen, …, Elizabeth M McNally, Janet K Snell-Bergeon, John T Wilkins
- JCI Insight, 10.1172/jci.insight.166956
Regulation of nucleotide metabolism in cancers and immune disorders
- Eunus S Ali
- Issam Ben-Sahra
- March 26, 2023
- kedalionlabs.com
- Eunus S Ali, Issam Ben-Sahra
- Trends Cell Biol, 10.1016/j.tcb.2023.03.003
The cell cycle loops UTP around CAD
- Issam Ben-Sahra
- February 7, 2023
- kedalionlabs.com
- Umakant Sahu, Umakant Sahu, Umakant Sahu, Issam Ben-Sahra, Umakant Sahu, Issam Ben-Sahra
- Nat Metab, 10.1038/s42255-023-00737-7
Purine synthesis suppression reduces the development and progression of pulmonary hypertension in rodent models
- Issam Ben-Sahra
- February 1, 2023
- kedalionlabs.com
- Qian Ma, Qiuhua Yang, Jiean Xu, …, Yunchao Su, David J R Fulton, Yuqing Huo
- Eur Heart J, 10.1093/eurheartj/ehad044
GATOR2 rings GATOR1 to speak to mTORC1
- Issam Ben-Sahra
- January 7, 2023
- kedalionlabs.com
- Umakant Sahu, Issam Ben-Sahra, Umakant Sahu, …, Issam Ben-Sahra, Umakant Sahu, Issam Ben-Sahra
- Mol Cell, 10.1016/j.molcel.2022.12.011
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia
- Issam Ben-Sahra
- December 9, 2022
- kedalionlabs.com
- Qi Jin, Blanca Gutierrez Diaz, Tim Pieters, …, John D Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos
- Sci Adv, 10.1126/sciadv.abq8437
ATIC-Associated De Novo Purine Synthesis Is Critically Involved in Proliferative Arterial Disease
- Issam Ben-Sahra
- September 8, 2022
- kedalionlabs.com
- Qian Ma, Qiuhua Yang, Jiean Xu, …, John M Asara, Issam Ben-Sahra, Yuqing Huo
- Circulation, 10.1161/circulationaha.121.058901
C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways
- Issam Ben-Sahra
- July 1, 2022
- kedalionlabs.com
- David R Amici, Daniel J Ansel, Kyle A Metz, …, Daniel R Foltz, Jian Li, Marc L Mendillo
- Proc Natl Acad Sci U S A, 10.1073/pnas.2111262119
The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
- Issam Ben-Sahra
- June 30, 2022
- kedalionlabs.com
- Eunus S Ali, Anna LipoÅ„ska, Brendan P O’Hara, …, Mee-Ngan F Yap, Marc L Mendillo, Issam Ben-Sahra
- Mol Cell, 10.1016/j.molcel.2022.06.008
ZFP36L2 suppresses mTORc1 through a P53-dependent pathway to prevent peripartum cardiomyopathy in mice
- Issam Ben-Sahra
- Zoltan Arany
- March 22, 2022
- kedalionlabs.com
- Hidemichi Kouzu, Yuki Tatekoshi, Hsiang-Chun Chang, …, Chunlei Chen, Perry J Blackshear, Hossein Ardehali
- J Clin Invest, 10.1172/jci154491