Academic lineage
- Frances H Arnold - Ph.D. student
Video highlight
In vitro continuous protein evolution empowered by machine learning and automation
- Tianhao Yu, Aashutosh Girish Boob, Nilmani Singh, …, Nilmani Singh, Yufeng Su, Huimin Zhao
- Cell Syst, 10.1016/j.cels.2023.04.006
Imaging Method Using CRISPR/dCas9 and Engineered gRNA Scaffolds Can Perturb Replication Timing at the HSPA1 Locus
- Xiong Xiong, Ipek Tasan, Che Yang, …, Pankaj Chaturvedi, Andrew S Belmont, Huimin Zhao
- ACS Synth Biol, 10.1021/acssynbio.2c00433
Enzyme function prediction using contrastive learning
- Tianhao Yu, Haiyang Cui, Jianan Canal Li, …, Yunan Luo, Guangde Jiang, Huimin Zhao
- Science, 10.1126/science.adf2465
Genome mining unveils a class of ribosomal peptides with two amino termini
- Hengqian Ren, Shravan R Dommaraju, Chunshuai Huang, …, David Sarlah, Douglas A Mitchell, Huimin Zhao
- Nat Commun, 10.1038/s41467-023-37287-1
Mass Spectrometry-Based High-Throughput Quantification of Bioproducts in Liquid Culture
- Shuaizhen Zhou, Zia Fatma, Pu Xue, …, Mingfeng Cao, Huimin Zhao, Jonathan V Sweedler
- Anal Chem, 10.1021/acs.analchem.2c04845
Mining and application of constitutive promoters from Rhodosporidium toruloides
- Xiao Guo, Zhenzhen Bai, Yang Zhang, …, Yang Zhang, Huimin Zhao, Shuobo Shi
- None, 10.1186/s13568-023-01522-1
Metabolic Engineering: Methodologies and Applications
- Michael J Volk, Vinh G Tran, Shih-I Tan, …, Pu Xue, Teresa A Martin, Huimin Zhao
- Chem Rev, 10.1021/acs.chemrev.2c00403
Engineering inducible biomolecular assemblies for genome imaging and manipulation in living cells
- Qin Peng, Ziliang Huang, Kun Sun, …, Sheng Zhong, Shu Chien, Yingxiao Wang
- Nat Commun, 10.1038/s41467-022-35504-x
The sound of silence: Transgene silencing in mammalian cell engineering
- Alan Cabera, Hailey I Edelstein, Fokion Glykofrydis, …, Lacramioara Bintu, Kate E Galloway, Tara L Deans
- Cell Syst, 10.1016/j.cels.2022.11.005
The Ever-Expanding Boundaries of Synthetic Biology
- Huimin Zhao, Huimin Zhao
- ACS Synth Biol, 10.1021/acssynbio.2c00582
Design and application of a kinetic model of lipid metabolism in Saccharomyces cerevisiae
- Shekhar Mishra, Ziyu Wang, Michael J Volk, …, Ziyu Wang, Michael J Volk, Huimin Zhao
- Metab Eng, 10.1016/j.ymben.2022.11.003
A scalable platform to discover antimicrobials of ribosomal origin
- Richard S Ayikpoe, Chengyou Shi, Alexander J Battiste, …, Wilfred A van der Donk, Douglas A Mitchell, Huimin Zhao
- Nat Commun, 10.1038/s41467-022-33890-w
Challenges and opportunities in C1-based biomanufacturing
- Weibo Qiao, Shijie Xu, Zihe Liu, Xiaoying Fu, Huimin Zhao, Shuobo Shi
- Bioresour Technol, 10.1016/j.biortech.2022.128095
Cas9-Based Metabolic Engineering of Issatchenkia orientalis for Enhanced Utilization of Cellulosic Hydrolysates
- Ye-Gi Lee, Chanwoo Kim, Nurzhan Kuanyshev, …, Yasuo Yoshikuni, Huimin Zhao, Yong-Su Jin
- J Agric Food Chem, 10.1021/acs.jafc.2c04251
Synthetic Biology 2.0: The Dawn of a New Era
- Huimin Zhao
- ACS Synth Biol, 10.1021/acssynbio.2c00332
Metabolic engineering of Rhodotorula toruloides IFO0880 improves C16 and C18 fatty alcohol production from synthetic media
- J Carl Schultz, Shekhar Mishra, Emily Gaither, …, Hoang Dinh, Costas Maranas, Huimin Zhao
- Microb Cell Fact, 10.1186/s12934-022-01750-3
CUT&RUN identifies centromeric DNA regions of Rhodotorula toruloides IFO0880
- J Carl Schultz, Mingfeng Cao, Andrea Mejia, Huimin Zhao
- FEMS Yeast Res, 10.1093/femsyr/foab066
Engineering robust microorganisms for organic acid production
- Vinh G Tran, Huimin Zhao
- J Ind Microbiol Biotechnol, 10.1093/jimb/kuab067
Directed Evolution: Methodologies and Applications
- Yajie Wang, Pu Xue, Mingfeng Cao, Tianhao Yu, Stephan T Lane, Huimin Zhao
- Chem Rev, 10.1021/acs.chemrev.1c00260
Cloning and characterization of a panel of mitochondrial targeting sequences for compartmentalization engineering in Saccharomyces cerevisiae
- Chang Dong, Zhuwei Shi, Lei Huang, Huimin Zhao, Zhinan Xu, Jiazhang Lian
- Biotechnol Bioeng, 10.1002/bit.27896
Precise Regulation of Cas9-Mediated Genome Engineering by Anti-CRISPR-Based Inducible CRISPR Controllers
- Surbhi Jain, Guanhua Xun, Shireen Abesteh, …, Ipek Tasan, Che Yang, Huimin Zhao
- ACS Synth Biol, 10.1021/acssynbio.0c00548
A rapid, accurate, scalable, and portable testing system for COVID-19 diagnosis
- Guanhua Xun, Stephan Thomas Lane, Vassily Andrew Petrov, Brandon Elliott Pepa, Huimin Zhao
- Nat Commun, 10.1038/s41467-021-23185-x
Engineering oleaginous yeast Rhodotorula toruloides for overproduction of fatty acid ethyl esters
- Yang Zhang, Jie Peng, Huimin Zhao, Shuobo Shi
- None, 10.1186/s13068-021-01965-3
Identification of novel metabolic engineering targets for S-adenosyl-L-methionine production in Saccharomyces cerevisiae via genome-scale engineering
- Chang Dong, J Carl Schultz, Wei Liu, …, Lei Huang, Zhinan Xu, Huimin Zhao
- Metab Eng, 10.1016/j.ymben.2021.03.005
TALEN outperforms Cas9 in editing heterochromatin target sites
- Surbhi Jain, Saurabh Shukla, Che Yang, …, Charles M Schroeder, Paul R Selvin, Huimin Zhao
- Nat Commun, 10.1038/s41467-020-20672-5
Optically guided mass spectrometry to screen microbial colonies for directed enzyme evolution
- Pu Xue, Tong Si, Huimin Zhao
- Methods Enzymol, 10.1016/bs.mie.2020.04.054
Two radical-dependent mechanisms for anaerobic degradation of the globally abundant organosulfur compound dihydroxypropanesulfonate
- Jiayi Liu, Yifeng Wei, Lianyun Lin, …, Huimin Zhao, Zhiguang Yuchi, Yan Zhang
- Proc Natl Acad Sci U S A, 10.1073/pnas.2003434117
Emerging molecular biology tools and strategies for engineering natural product biosynthesis
- Wei Xu, Evaldas Klumbys, Ee Lui Ang, Huimin Zhao
- Metab Eng, 10.1016/j.mec.2019.e00108
Photoenzymatic enantioselective intermolecular radical hydroalkylation
- Xiaoqiang Huang, Binju Wang, Yajie Wang, Guangde Jiang, Jianqiang Feng, Huimin Zhao
- Nature, 10.1038/s41586-020-2406-6
Biosystems Design by Machine Learning
- Michael Jeffrey Volk, Ismini Lourentzou, Shekhar Mishra, Lam Tung Vo, Chengxiang Zhai, Huimin Zhao
- ACS Synth Biol, 10.1021/acssynbio.0c00129
Fine-tuning the regulation of Cas9 expression levels for efficient CRISPR-Cas9 mediated recombination in Streptomyces
- Suhui Ye, Behnam Enghiad, Huimin Zhao, Eriko Takano
- J Ind Microbiol Biotechnol, 10.1007/s10295-020-02277-5
DNA punch cards for storing data on native DNA sequences via enzymatic nicking
- S Kasra Tabatabaei, Boya Wang, Nagendra Bala Murali Athreya, …, David Soloveichik, Huimin Zhao, Olgica Milenkovic
- Nat Commun, 10.1038/s41467-020-15588-z
Integrating biocatalysis with chemocatalysis for selective transformations
- Xiaoqiang Huang, Mingfeng Cao, Huimin Zhao
- Curr Opin Chem Biol, 10.1016/j.cbpa.2020.02.004
A New Biosensor for Stilbenes and a Cannabinoid Enabled by Genome Mining of a Transcriptional Regulator
- Huihua Sun, Huimin Zhao, Ee Lui Ang
- ACS Synth Biol, 10.1021/acssynbio.9b00443
A Pathway for Degradation of Uracil to Acetyl Coenzyme A in Bacillus megaterium
- Di Zhu, Yifeng Wei, Jinyu Yin, …, Ee Lui Ang, Huimin Zhao, Yan Zhang
- Appl Environ Microbiol, 10.1128/aem.02837-19
Computational Tools for Discovering and Engineering Natural Product Biosynthetic Pathways
- Hengqian Ren, Chengyou Shi, Huimin Zhao
- None, 10.1016/j.isci.2019.100795
Identification and Characterization of Citrus Peel Uronic Acid Oxidase
- Yifeng Wei, Yee Ling Tan, Ee Lui Ang, Huimin Zhao
- Chembiochem, 10.1002/cbic.201900546
A gene cluster for taurine sulfur assimilation in an anaerobic human gut bacterium
- Meining Xing, Yifeng Wei, Gaoqun Hua, …, Ee Lui Ang, Huimin Zhao, Yan Zhang
- Biochem J, 10.1042/bcj20190486
A Pathway for Isethionate Dissimilation in Bacillus krulwichiae
- Yang Tong, Yifeng Wei, Yiling Hu, Ee Lui Ang, Huimin Zhao, Yan Zhang
- Appl Environ Microbiol, 10.1128/aem.00793-19
Directed evolution of artificial metalloenzymes for in vivo metathesis
- Markus Jeschek, Raphael Reuter, Tillmann Heinisch, …, Juliane Klehr, Sven Panke, Thomas R Ward
- Nature, 10.1038/nature19114
