Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth
- Emilie Abby, Stefan C Dentro, Michael W J Hall, …, Moritz Gerstung, Benjamin A Hall, Philip H Jones
- Nat Genet, 10.1038/s41588-022-01280-z
Pseudoalignment tools as an efficient alternative to detect repeated transposable elements in scRNAseq data
- Jaime MartÃnez de Villarreal, Mark Kalisz, Gabriel Piedrafita, …, Dafni Chondronasiou, Manuel Serrano, Francisco X Real
- Bioinformatics, 10.1093/bioinformatics/btac737
Cysteine and iron accelerate the formation of ribose-5-phosphate, providing insights into the evolutionary origins of the metabolic network structure
- Gabriel Piedrafita, Sreejith J Varma, Cecilia Castro, …, Lukasz Szyrwiel, Julian L Griffin, Markus Ralser
- PLoS Biol, 10.1371/journal.pbio.3001468
Mutant clones in normal epithelium outcompete and eliminate emerging tumours
- B Colom, A Herms, M W J Hall, …, M Gerstung, B A Hall, P H Jones
- Nature, 10.1038/s41586-021-03965-7
Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium
- Bartomeu Colom, Maria P Alcolea, Gabriel Piedrafita, …, Inigo Martincorena, Benjamin A Hall, Philip H Jones
- Nat Genet, 10.1038/s41588-020-0624-3
A single-progenitor model as the unifying paradigm of epidermal and esophageal epithelial maintenance in mice
- Gabriel Piedrafita, Vasiliki Kostiou, Agnieszka Wabik, …, Kasumi Murai, Benjamin A Hall, Philip H Jones
- Nat Commun, 10.1038/s41467-020-15258-0
Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation
- David Fernandez-Antoran, Gabriel Piedrafita, Kasumi Murai, …, Albert Herms, Christian Frezza, Philip H Jones
- Cell Stem Cell, 10.1016/j.stem.2019.06.011
Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations
- Kasumi Murai, Greta Skrupskelyte, Gabriel Piedrafita, …, Allon M Klein, Benjamin A Hall, Philip H Jones
- Cell Stem Cell, 10.1016/j.stem.2018.08.017
Nonenzymatic gluconeogenesis-like formation of fructose 1,6-bisphosphate in ice
- Christoph B Messner, Paul C Driscoll, Gabriel Piedrafita, Michael F L De Volder, Markus Ralser
- Proc Natl Acad Sci U S A, 10.1073/pnas.1702274114
Permeability-driven selection in a semi-empirical protocell model: the roots of prebiotic systems evolution
- Gabriel Piedrafita, Pierre-Alain Monnard, Fabio Mavelli, Kepa Ruiz-Mirazo
- Sci Rep, 10.1038/s41598-017-02799-6
Identifying ultrasensitive HGF dose-response functions in a 3D mammalian system for synthetic morphogenesis
- Vivek Raj Senthivel, Marc Sturrock, Gabriel Piedrafita, Mark Isalan
- Sci Rep, 10.1038/srep39178
The Impact of Non-Enzymatic Reactions and Enzyme Promiscuity on Cellular Metabolism during (Oxidative) Stress Conditions
- Gabriel Piedrafita, Markus A Keller, Markus Ralser
- Biomolecules, 10.3390/biom5032101
The widespread role of non-enzymatic reactions in cellular metabolism
- Markus A Keller, Gabriel Piedrafita, Markus Ralser
- Curr Opin Biotechnol, 10.1016/j.copbio.2014.12.020
Viability conditions for a compartmentalized protometabolic system: a semi-empirical approach
- Gabriel Piedrafita, Kepa Ruiz-Mirazo, Pierre-Alain Monnard, Athel Cornish-Bowden, Francisco Montero
- PLoS One, 10.1371/journal.pone.0039480