Spatiotemporal evolution of the clear cell renal cell carcinoma microenvironment links intra-tumoral heterogeneity to immune escape
- Mahdi Golkaram, Fengshen Kuo, Sounak Gupta, …, Ed Reznik, Timothy A Chan, A Ari Hakimi
- Genome Med, 10.1186/s13073-022-01146-3
MIRTH: Metabolite Imputation via Rank-Transformation and Harmonization
- Benjamin A Freeman, Sophie Jaro, Tricia Park, Sam Keene, Wesley Tansey, Ed Reznik
- Genome Biol, 10.1186/s13059-022-02738-3
Mitochondrial DNA is a major source of driver mutations in cancer
- Minsoo Kim, Mahnoor Mahmood, Ed Reznik, …, Mahnoor Mahmood, Ed Reznik, Payam A Gammage
- Trends Cancer, 10.1016/j.trecan.2022.08.001
A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear-Cell Renal Cell Carcinoma
- Phillip M Rappold, Lynda Vuong, Josef Leibold, …, Robert J Motzer, Martin H Voss, A Ari Hakimi
- Cancer Discov, 10.1158/2159-8290.cd-21-0925
Genomic and Metabolic Hallmarks of SDH- and FH-deficient Renal Cell Carcinomas
- Angela Yoo, Cerise Tang, Mark Zucker, …, Ritesh R Kotecha, A Ari Hakimi, Ed Reznik
- Eur Urol Focus, 10.1016/j.euf.2021.12.002
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients
- Bastien Nguyen, Christopher Fong, Anisha Luthra, …, Samuel F Bakhoum, Francisco Sanchez-Vega, Nikolaus Schultz
- Cell, 10.1016/j.cell.2022.01.003
High Response Rate and Durability Driven by HLA Genetic Diversity in Patients with Kidney Cancer Treated with Lenvatinib and Pembrolizumab
- Chung-Han Lee, Renzo G DiNatale, Diego Chowell, …, A Ari Hakimi, Robert J Motzer, Timothy A Chan
- Mol Cancer Res, 10.1158/1541-7786.mcr-21-0053
Re: Stanley Weng, Renzo G. DiNatale, Andrew Silagy, et al. The Clinicopathologic and Molecular Landscape of Clear Cell Papillary Renal Cell Carcinoma: Implications in Diagnosis and Management. Eur Urol 2021;79:468-77
- Sounak Gupta, Beth A Pitel, Shannon M Knight, Kevin C Halling, Rafael E Jimenez, John C Cheville
- Eur Urol, 10.1016/j.eururo.2021.05.011
Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA
- Alexander N Gorelick, Minsoo Kim, Walid K Chatila, …, Barry S Taylor, Payam A Gammage, Ed Reznik
- Nat Metab, 10.1038/s42255-021-00378-8
A qualitative framework of non-selection factors for cytoreductive nephrectomy
- Andrew W Silagy, Kyrollis Attalla, Renzo G Dinatale, …, Jonathan A Coleman, A Ari Hakimi, Paul Russo
- World J Urol, 10.1007/s00345-021-03650-4
The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing
- Sara Parsa, Ana Ortega-Molina, Hsia-Yuan Ying, …, Kivanc Birsoy, Ari M Melnick, Hans-Guido Wendel
- Nat Cancer, 10.1038/s43018-020-0080-0
Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs
- Kevin Hadi, Xiaotong Yao, Julie M Behr, …, Juan Miguel Mosquera, Olivier Elemento, Marcin Imielinski
- Cell, 10.1016/j.cell.2020.08.006
A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response
- A Ari Hakimi, Kyrollis Attalla, Renzo G DiNatale, …, Martin H Voss, Timothy A Chan, Robert J Motzer
- Nat Commun, 10.1038/s41467-020-17965-0
Putative Drivers of Aggressiveness in TCEB1-mutant Renal Cell Carcinoma: An Emerging Entity with Variable Clinical Course
- Renzo G DiNatale, Alexander N Gorelick, Vladimir Makarov, …, Ed Reznik, Satish K Tickoo, A Ari Hakimi
- Eur Urol Focus, 10.1016/j.euf.2019.11.013
Metabolomics informs common patterns of molecular dysfunction across histologies of renal cell carcinoma
- Renzo G DiNatale, Alejandro Sanchez, A Ari Hakimi, Ed Reznik
- Urol Oncol, 10.1016/j.urolonc.2019.04.028