Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies
- Collin D Edington, Wen Li Kelly Chen, Emily Geishecker, …, David L Trumper, Murat Cirit, Linda G Griffith
- Sci Rep, 10.1038/s41598-018-22749-0
Profiling of metalloprotease activities in cerebrospinal fluids of patients with neoplastic meningitis
- Catharina Conrad, Kristina Dorzweiler, Miles A Miller, Douglas A Lauffenburger, Herwig Strik, Jörg W Bartsch
- Fluids Barriers CNS, 10.1186/s12987-017-0070-5
An engineering design approach to systems biology
- Kevin A Janes, Preethi L Chandran, Roseanne M Ford, …, Shayn M Peirce, Jeffrey J Saucerman, Douglas A Lauffenburger
- Integr Biol (Camb), 10.1039/c7ib00014f
Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System
- Ujjal Sarkar, Kodihalli C Ravindra, Emma Large, …, Douglas A Lauffenburger, Linda G Griffith, Steven R Tannenbaum
- Drug Metab Dispos, 10.1124/dmd.116.074005
Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility
- Hilde Jørgensen, Abby S Hill, Michael T Beste, …, Douglas A Lauffenburger, Linda G Griffith, Erik Qvigstad
- Fertil Steril, 10.1016/j.fertnstert.2017.03.013
On-demand dissolution of modular, synthetic extracellular matrix reveals local epithelial-stromal communication networks
- Jorge Valdez, Christi D Cook, Caroline Chopko Ahrens, …, Douglas Lauffenburger, Forest White, Linda Griffith
- Biomaterials, 10.1016/j.biomaterials.2017.03.030
Local remodeling of synthetic extracellular matrix microenvironments by co-cultured endometrial epithelial and stromal cells enables long-term dynamic physiological function
- Christi D Cook, Abby S Hill, Margaret Guo, …, Keith B Isaacson, Douglas A Lauffenburger, Linda G Griffith
- Integr Biol (Camb), 10.1039/c6ib00245e
Virus-driven Inflammation Is Associated With the Development of bNAbs in Spontaneous Controllers of HIV
- Anne-Sophie Dugast, Kelly Arnold, Giuseppe Lofano, …, Douglas S Kwon, Brandon F Keele, Galit Alter
- Clin Infect Dis, 10.1093/cid/cix057
Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors
- Li Tan, Deepak Gurbani, Ellen L Weisberg, …, Kenneth D Westover, Peter K Sorger, Nathanael S Gray
- Bioorg Med Chem, 10.1016/j.bmc.2016.11.034
Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation
- Douglas S Jones, Anne P Jenney, Jennifer L Swantek, John M Burke, Douglas A Lauffenburger, Peter K Sorger
- Nat Chem Biol, 10.1038/nchembio.2211
Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses
- Kelly D Moynihan, Cary F Opel, Gregory L Szeto, …, Douglas A Lauffenburger, K Dane Wittrup, Darrell J Irvine
- Nat Med, 10.1038/nm.4200
Differential selective pressure alters rate of drug resistance acquisition in heterogeneous tumor populations
- Daphne Sun, Simona Dalin, Michael T Hemann, Douglas A Lauffenburger, Boyang Zhao
- Sci Rep, 10.1038/srep36198
The alternatively-included 11a sequence modifies the effects of Mena on actin cytoskeletal organization and cell behavior
- Michele Balsamo, Chandrani Mondal, Guillaume Carmona, …, John S Condeelis, Douglas A Lauffenburger, Frank B Gertler
- Sci Rep, 10.1038/srep35298
