Capturing copper to inhibit inflammation
- Christopher J Chang, Donita C Brady, Christopher J Chang, Donita C Brady
- Nat Chem Biol, 10.1038/s41589-023-01383-6
RASopathy mutations open new insights into the mechanism of BRAF activation
- Arvin C Dar, Donita C Brady, Arvin C Dar, …, Donita C Brady, Arvin C Dar, Donita C Brady
- Mol Cell, 10.1016/j.molcel.2022.10.034
Oxidation state-specific fluorescent copper sensors reveal oncogene-driven redox changes that regulate labile copper(II) pools
- Aidan T Pezacki, Carson D Matier, Xingxing Gu, …, Timothy A Su, Donita C Brady, Christopher J Chang
- Proc Natl Acad Sci U S A, 10.1073/pnas.2202736119
Copper Modulates the Catalytic Activity of Protein Kinase CK2
- John E Chojnowski, Rongrong Li, Tiffany Tsang, …, Simon Cocklin, Donita C Brady, Todd I Strochlic
- None, 10.3389/fmolb.2022.878652
Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death
- Paul A Cobine, Donita C Brady, Paul A Cobine, Donita C Brady
- Mol Cell, 10.1016/j.molcel.2022.05.001
Direct anabolic metabolism of three-carbon propionate to a six-carbon metabolite occurs in vivo across tissues and species
- Mary T Doan, Michael D Neinast, Erika L Varner, …, Kenneth B Marguiles, Zoltan Arany, Nathaniel W Snyder
- J Lipid Res, 10.1016/j.jlr.2022.100224
The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17
- Daniele Chaves-Moreira, Marilyn A Mitchell, Cristina Arruza, …, Kate Lawrenson, Patrice J Morin, Ronny Drapkin
- Sci Signal, 10.1126/scisignal.abm2496
BRAFV600E-Driven Lung Adenocarcinoma Requires Copper to Sustain Autophagic Signaling and Processing
- Tiffany Tsang, Xingxing Gu, Caroline I Davis, …, Jessica M Posimo, Zoey A Miller, Donita C Brady
- Mol Cancer Res, 10.1158/1541-7786.mcr-21-0250
Understanding and drugging RAS: 40 years to break the tip of the iceberg
- Donita C Brady, Julija Hmeljak, Arvin C Dar
- Dis Model Mech, 10.1242/dmm.049519
Loss of p19Arf promotes fibroblast survival during leucine deprivation
- Kerry C Roby, Allyson Lieberman, Bang-Jin Kim, …, Donita C Brady, Constantinos Koumenis, Sandra Ryeom
- Biol Open, 10.1242/bio.058728
Connecting copper and cancer: from transition metal signalling to metalloplasia
- Eva J Ge, Ashley I Bush, Angela Casini, …, Peng Yuan, Donita C Brady, Christopher J Chang
- Nat Rev Cancer, 10.1038/s41568-021-00417-2
The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation
- Michael Grasso, Gavin J Bond, Ye-Jin Kim, …, Duane D Winkler, Ronen Marmorstein, Donita C Brady
- J Biol Chem, 10.1016/j.jbc.2021.101314
Copper biology
- Tiffany Tsang, Caroline I Davis, Donita C Brady
- Curr Biol, 10.1016/j.cub.2021.03.054
Academic careers and the COVID-19 pandemic: Reversing the tide
- Rotonya M Carr, Meghan B Lane-Fall, Eugenia South, …, George Dalembert, Risa Lavizzo-Mourey, Roy Hamilton
- Sci Transl Med, 10.1126/scitranslmed.abe7189