Genetically encoded tools for measuring and manipulating metabolism
- Mangyu Choe, Denis V Titov
- Nat Chem Biol, 10.1038/s41589-022-01012-8
Listeria monocytogenes requires cellular respiration for NAD + regeneration and pathogenesis
- Rafael Rivera-Lugo, David Deng, Andrea Anaya-Sanchez, …, Caroline M Ajo-Franklin, Daniel A Portnoy, Samuel H Light
- Elife, 10.7554/elife.75424
Physical bioenergetics: Energy fluxes, budgets, and constraints in cells
- Xingbo Yang, Matthias Heinemann, Jonathon Howard, …, Denis V Titov, Jin Wang, Peter J Foster
- Proc Natl Acad Sci U S A, 10.1073/pnas.2026786118
Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell
- Eran Mick, Denis V Titov, Owen S Skinner, Rohit Sharma, Alexis A Jourdain, Vamsi K Mootha
- Elife, 10.7554/elife.49178
A genetically encoded tool for manipulation of NADP + /NADPH in living cells
- Valentin Cracan, Denis V Titov, Hongying Shen, Zenon Grabarek, Vamsi K Mootha
- Nat Chem Biol, 10.1038/nchembio.2454
Covalent modification of a cysteine residue in the XPB subunit of the general transcription factor TFIIH through single epoxide cleavage of the transcription inhibitor triptolide
- Qing-Li He, Denis V Titov, Jing Li, …, Yingming Zhao, Daniel Romo, Jun O Liu
- Angew Chem Int Ed Engl, 10.1002/anie.201408817
Identification and validation of protein targets of bioactive small molecules
- Denis V Titov, Jun O Liu
- Bioorg Med Chem, 10.1016/j.bmc.2011.11.070
XPB, a subunit of TFIIH, is a target of the natural product triptolide
- Denis V Titov, Benjamin Gilman, Qing-Li He, …, Jennifer F Kugel, James A Goodrich, Jun O Liu
- Nat Chem Biol, 10.1038/nchembio.522