PKM2 rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistance
- Justine Bailleul, Yangjingyi Ruan, Lobna Abdulrahman, …, Costas A Lyssiotis, Daniel R Wahl, Erina Vlashi
- Neuro Oncol, 10.1093/neuonc/noad103
An unexpected pathway to polyamines in pancreatic cancer
- Dominik Awad, Costas A Lyssiotis, Dominik Awad, …, Costas A Lyssiotis, Dominik Awad, Costas A Lyssiotis
- Mol Cell, 10.1016/j.molcel.2023.05.014
Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis
- Juan J Apiz Saab, Lindsey N Dzierozynski, Patrick B Jonker, …, Kay F Macleod, Christopher R Weber, Alexander Muir
- Elife, 10.7554/elife.81289
Uridine-derived ribose fuels glucose-restricted pancreatic cancer
- Zeribe C Nwosu, Matthew H Ward, Peter Sajjakulnukit, …, Marina Pasca di Magliano, Anguraj Sadanandam, Costas A Lyssiotis
- Nature, 10.1038/s41586-023-06073-w
GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity
- Dionysios C Watson, Defne Bayik, Simon Storevik, …, Jubayer A Hossain, Hrvoje Miletic, Justin D Lathia
- Nat Cancer, 10.1038/s43018-023-00556-5
Ether phospholipids are required for mitochondrial reactive oxygen species homeostasis
- I-Lin Ho, Melinda Soeung, Er-Yen Yen, …, Joseph R Marszalek, Giulio F Draetta, Haoqiang Ying
- Nat Commun, 10.1038/s41467-023-37924-9
PTEN-induced kinase PINK1 supports colorectal cancer growth by regulating the labile iron pool
- Brandon Chen, Nupur K Das, Indrani Talukder, …, Joseph D Mancias, Costas A Lyssiotis, Yatrik M Shah
- J Biol Chem, 10.1016/j.jbc.2023.104691
Metabolomic profiles of human glioma inform patient survival
- Andrew J Scott, Luis O Correa, Donna Edwards, …, Arvind Rao, Costas A Lyssiotis, Daniel R Wahl
- Antioxid Redox Signal, 10.1089/ars.2022.0085