Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis
- Juan J Apiz Saab, Lindsey N Dzierozynski, Patrick B Jonker, …, Kay F Macleod, Christopher R Weber, Alexander Muir
- Elife, 10.7554/elife.81289
Uridine-derived ribose fuels glucose-restricted pancreatic cancer
- Zeribe C Nwosu, Matthew H Ward, Peter Sajjakulnukit, …, Marina Pasca di Magliano, Anguraj Sadanandam, Costas A Lyssiotis
- Nature, 10.1038/s41586-023-06073-w
Screening in serum-derived medium reveals differential response to compounds targeting metabolism
- Keene L Abbott, Ahmed Ali, Dominick Casalena, …, Alexander Muir, Douglas S Auld, Matthew G Vander Heiden
- None, 10.1101/2023.02.25.529972
Biotin-dependent cell envelope remodelling is required for Mycobacterium abscessus survival in lung infection
- Mark R Sullivan, Kerry McGowen, Qiang Liu, …, Courtney C Aldrich, Alexander Muir, Eric J Rubin
- Nat Microbiol, 10.1038/s41564-022-01307-5
The requirement for mitochondrial respiration in cancer varies with disease stage
- Colin Sheehan, Alexander Muir
- PLoS Biol, 10.1371/journal.pbio.3001800
Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer
- Yogev Sela, Jinyang Li, Shivahamy Maheswaran, …, Ophir Shalem, Chi V Dang, Ben Z Stanger
- Cancer Res, 10.1158/0008-5472.can-22-0431
Cell-programmed nutrient partitioning in the tumour microenvironment
- Bradley I Reinfeld, Matthew Z Madden, Melissa M Wolf, …, H Charles Manning, Jeffrey C Rathmell, W Kimryn Rathmell
- Nature, 10.1038/s41586-021-03442-1
Arginase Therapy Combines Effectively with Immune Checkpoint Blockade or Agonist Anti-OX40 Immunotherapy to Control Tumor Growth
- Mark D Badeaux, Annah S Rolig, Giulia Agnello, …, James E Wooldridge, William L Redmond, Scott W Rowlinson
- Cancer Immunol Res, 10.1158/2326-6066.cir-20-0317