A transcriptome-informed QSP model of metastatic triple-negative breast cancer identifies predictive biomarkers for PD-1 inhibition
- Theinmozhi Arulraj, Hanwen Wang, Leisha A Emens, …, Leisha A Emens, Cesar A Santa-Maria, Aleksander S Popel
- Sci Adv, 10.1126/sciadv.adg0289
Quantifying Intratumoral Heterogeneity and Immunoarchitecture Generated In-Silico by a Spatial Quantitative Systems Pharmacology Model
- Mehdi Nikfar, Haoyang Mi, Chang Gong, …, Chang Gong, Holly Kimko, Aleksander S Popel
- None, 10.3390/cancers15102750
Vascular phenotyping of the invasive front in breast cancer using a 3D angiogenesis atlas
- Akanksha Bhargava, Aleksander S Popel, Arvind P Pathak, …, Akanksha Bhargava, Aleksander S Popel, Arvind P Pathak
- Microvasc Res, 10.1016/j.mvr.2023.104555
Uncovering the spatial landscape of molecular interactions within the tumor microenvironment through latent spaces
- Atul Deshpande, Melanie Loth, Dimitrios N Sidiropoulos, …, Genevieve Stein-O’Brien, Luciane T Kagohara, Elana J Fertig
- Cell Syst, 10.1016/j.cels.2023.03.004
The tumor microenvironment and triple-negative breast cancer aggressiveness: shedding light on mechanisms and targeting
- Natsuki Furukawa, Vered Stearns, Cesar A Santa-Maria, …, Vered Stearns, Cesar A Santa-Maria, Aleksander S Popel
- Expert Opin Ther Targets, 10.1080/14728222.2022.2170779
Quantitative Spatial Profiling of Immune Populations in Pancreatic Ductal Adenocarcinoma Reveals Tumor Microenvironment Heterogeneity and Prognostic Biomarkers
- Haoyang Mi, Shamilene Sivagnanam, Courtney B Betts, …, Elizabeth M Jaffee, Lisa M Coussens, Aleksander S Popel
- Cancer Res, 10.1158/0008-5472.can-22-1190
Label Cleaning Multiple Instance Learning: Refining Coarse Annotations on Single Whole-Slide Images
- Zhenzhen Wang, Carla Saoud, Sintawat Wangsiricharoen, …, Aaron W James, Aleksander S Popel, Jeremias Sulam
- IEEE Trans Med Imaging, 10.1109/tmi.2022.3202759
Simulations of tumor growth and response to immunotherapy by coupling a spatial agent-based model with a whole-patient quantitative systems pharmacology model
- Alvaro Ruiz-Martinez, Chang Gong, Hanwen Wang, …, Haoyang Mi, Holly Kimko, Aleksander S Popel
- PLoS Comput Biol, 10.1371/journal.pcbi.1010254
Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of immunotherapy in triple-negative breast cancer
- Hanwen Wang, Chen Zhao, Cesar A Santa-Maria, Leisha A Emens, Aleksander S Popel
- None, 10.1016/j.isci.2022.104702
Systems biology of angiogenesis signaling: Computational models and omics
- Yu Zhang, Hanwen Wang, Rebeca Hannah M Oliveira, Chen Zhao, Aleksander S Popel
- WIREs Mech Dis, 10.1002/wsbm.1550