RabLab April 2023

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Cell

Cachexia: A systemic consequence of progressive, unresolved disease.

2023-04-28

PubMed:37116469; DOI:10.1016/j.cell.2023.03.028

Miriam Ferrer1, Tracy G Anthony2, Janelle S Ayres3, Giulia Biffi4, Justin C Brown5, Bette J Caan6, Elizabeth M Cespedes Feliciano6, Anthony P Coll7, Richard F Dunne8, Marcus D Goncalves9, Jonas Grethlein10, Steven B Heymsfield5, Sheng Hui11, Mariam Jamal-Hanjani12, Jie Min Lam13, David Y Lewis14, David McCandlish15, Karen M Mustian8, Stephen O’Rahilly7, Norbert Perrimon16, Eileen P White17, Tobias Janowitz18

Affiliations
  1. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; MRC Cancer Unit, University of Cambridge, Hutchison Research Centre, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK
  2. Department of Nutritional Sciences, Rutgers School of Environmental and Biological Sciences, The State University of New Jersey, New Brunswick, NJ 08901, USA
  3. Salk Institute for Biological Studies, La Jolla, CA 92037, USA
  4. University of Cambridge, Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK
  5. Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
  6. Kaiser Permanente Northern California Division of Research, Oakland, CA 94612, USA
  7. Wellcome Trust-MRC Institute of Metabolic Science and MRC Metabolic Diseases Unit, University of Cambridge, Cambridge CB2 0QQ, UK
  8. University of Rochester Medical Center, University of Rochester, Rochester, NY 14642, USA
  9. Division of Endocrinology, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA
  10. Ruprecht Karl University of Heidelberg, Heidelberg 69117, Germany
  11. Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA
  12. Department of Medical Oncology, University College London Hospitals, London WC1E 6DD, UK; Cancer Research UK Lung Cancer Centre of Excellence and Cancer Metastasis Laboratory, University College London Cancer Institute, London WC1E 6DD, UK
  13. Cancer Research UK Lung Cancer Centre of Excellence and Cancer Metastasis Laboratory, University College London Cancer Institute, London WC1E 6DD, UK
  14. The Beatson Institute for Cancer Research, Cancer Research UK, Glasgow G61 1BD, UK
  15. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
  16. Department of Genetics, Blavatnik Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
  17. Rutgers Cancer Institute of New Jersey, Department of Molecular Biology and Biochemistry, Rutgers University, The State University of New Jersey, New Brunswick, NJ 08901, USA; Ludwig Princeton Branch, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ 08544, USA
  18. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; Northwell Health Cancer Institute, Northwell Health, New Hyde Park, NY 11042, USA.
JCI insight

Maternal low-calorie sweetener consumption rewires hypothalamic melanocortin circuits via a gut microbial co-metabolite pathway.

2023-04-04

PubMed:37014702; DOI:10.1172/jci.insight.156397

Soyoung Park1, Amine M Belfoul2, Marialetizia Rastelli2, Alice Jang1, Magali Monnoye3, Hosung Bae4, Anna Kamitakahara1, Patrick Giavalisco5, Shan Sun6, Pierre-Yves Barelle2, Jasmine Plows7, Cholsoon Jang4, Anthony Fodor6, Michael I Goran7, Sebastien G Bouret2

AI-generated cartoon-styled profile picture of Cholsoon Jang

Affiliations
  1. The Saban Research Institute, Developmental Neuroscience Program, Children’s Hospital Los Angeles, University of Southern California, Los Angeles, California, USA
  2. University Lille, Inserm, CHU Lille, Laboratory of development and plasticity of the Neuroendocrine brain, Lille Neuroscience & Cognition, Inserm UMR-S1172, Lille, France
  3. Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France
  4. Department of Biological Chemistry, School of Medicine, University of California at Irvine, Irvine, California, USA
  5. Metabolomics Core Facility, Max Planck Institute for Biology of Ageing, Cologne, Germany
  6. Department of Bioinformatics and Genomics, College of Computing and Informatics, University of North Carolina Charlotte, Charlotte, North Carolina, USA
  7. Center for Endocrinology, Diabetes and Metabolism, Children’s Hospital Los Angeles, University of Southern California, Los Angeles, California, USA

cancer-and-disease

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Carcinogenesis

The environmental carcinogen benzo[a]pyrene regulates epigenetic reprogramming and metabolic rewiring in a two-stage mouse skin carcinogenesis model.

2023-04-26

PubMed:37100755; DOI:10.1093/carcin/bgad024

Md Shahid Sarwar1, Christina N Ramirez1, Hsiao-Chen Dina Kuo1, Pochung Chou1, Renyi Wu1, Davit Sargsyan1, Yuqing Yang1, Ahmad Shannar1, Rebecca Mary Peter1, Ran Yin1, Yujue Wang2, Xiaoyang Su2, Ah-Ng Kong1

Affiliations
  1. Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
  2. Metabolomics Shared Resource, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA
International journal of molecular sciences

AI-Predicted mTOR Inhibitor Reduces Cancer Cell Proliferation and Extends the Lifespan of C. elegans .

2023-04-25

PubMed:37175557; DOI:10.3390/ijms24097850

Tinka Vidovic1, Alexander Dakhovnik2, Oleksii Hrabovskyi3, Michael R MacArthur4, Collin Y Ewald2

Affiliations
  1. Tinka Therapeutics, Fra Ivana Rozica 7, 21276 Vrgorac, Croatia
  2. Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, CH-8603 Schwerzenbach, Switzerland
  3. Palladin Institute of Biochemistry of the NAS of Ukraine, 02000 Kyiv, Ukraine
  4. Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA

human-health

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The Journal of clinical investigation

Hepatocyte SREBP signaling mediates clock communication within the liver.

2023-04-17

PubMed:37066875; DOI:10.1172/JCI163018

Dongyin Guan1, Hosung Bae2, Dishu Zhou1, Ying Chen1, Chunjie Jiang1, Cam Mong La1, Yang Xiao3, Kun Zhu3, Wenxiang Hu3, Trang Minh Trinh3, Panpan Liu1, Ying Xiong3, Bishuang Cai4, Cholsoon Jang2, Mitchell A Lazar3

AI-generated cartoon-styled profile picture of Cholsoon Jang

Affiliations
  1. Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
  2. Department of Biological Chemistry, University of California Irvine, Irvine, California, USA
  3. Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
  4. Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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