RabLab April 2023

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Cell

Cachexia: A systemic consequence of progressive, unresolved disease.

2023-04-28

PubMed:37116469; DOI:10.1016/j.cell.2023.03.028

Miriam Ferrer¹, Tracy G Anthony², Janelle S Ayres³, Giulia Biffi⁴, Justin C Brown⁵, Bette J Caan⁶, Elizabeth M Cespedes Feliciano⁶, Anthony P Coll⁷, Richard F Dunne⁸, Marcus D Goncalves⁹, Jonas Grethlein¹⁰, Steven B Heymsfield⁵, Sheng Hui¹¹, Mariam Jamal-Hanjani¹², Jie Min Lam¹³, David Y Lewis¹⁴, David McCandlish¹⁵, Karen M Mustian⁸, Stephen O’Rahilly⁷, Norbert Perrimon¹⁶, Eileen P White¹⁷, Tobias Janowitz¹⁸

Affiliations

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; MRC Cancer Unit, University of Cambridge, Hutchison Research Centre, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK
Department of Nutritional Sciences, Rutgers School of Environmental and Biological Sciences, The State University of New Jersey, New Brunswick, NJ 08901, USA
Salk Institute for Biological Studies, La Jolla, CA 92037, USA
University of Cambridge, Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Kaiser Permanente Northern California Division of Research, Oakland, CA 94612, USA
Wellcome Trust-MRC Institute of Metabolic Science and MRC Metabolic Diseases Unit, University of Cambridge, Cambridge CB2 0QQ, UK
University of Rochester Medical Center, University of Rochester, Rochester, NY 14642, USA
Division of Endocrinology, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA
Ruprecht Karl University of Heidelberg, Heidelberg 69117, Germany
Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA
Department of Medical Oncology, University College London Hospitals, London WC1E 6DD, UK; Cancer Research UK Lung Cancer Centre of Excellence and Cancer Metastasis Laboratory, University College London Cancer Institute, London WC1E 6DD, UK
Cancer Research UK Lung Cancer Centre of Excellence and Cancer Metastasis Laboratory, University College London Cancer Institute, London WC1E 6DD, UK
The Beatson Institute for Cancer Research, Cancer Research UK, Glasgow G61 1BD, UK
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Department of Genetics, Blavatnik Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
Rutgers Cancer Institute of New Jersey, Department of Molecular Biology and Biochemistry, Rutgers University, The State University of New Jersey, New Brunswick, NJ 08901, USA; Ludwig Princeton Branch, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ 08544, USA
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; Northwell Health Cancer Institute, Northwell Health, New Hyde Park, NY 11042, USA.

Cachexia is a complex condition that can result from various diseases and involves distinct inflammatory, metabolic, and neuro-modulatory drivers.
Understanding the etiology of cachexia may lead to new therapeutic approaches and better patient care.

2023-05-04

Thanks for the positive comments and feedback on our review on cachexia @miriamferrer95 @CancerGrand Very happy about the broad readership.

Cachexia: A systemic consequence of progressive, unresolved disease

2023-05-04

JCI insight

Maternal low-calorie sweetener consumption rewires hypothalamic melanocortin circuits via a gut microbial co-metabolite pathway.

2023-04-04

PubMed:37014702; DOI:10.1172/jci.insight.156397

Soyoung Park¹, Amine M Belfoul², Marialetizia Rastelli², Alice Jang¹, Magali Monnoye³, Hosung Bae⁴, Anna Kamitakahara¹, Patrick Giavalisco⁵, Shan Sun⁶, Pierre-Yves Barelle², Jasmine Plows⁷, Cholsoon Jang⁴, Anthony Fodor⁶, Michael I Goran⁷, Sebastien G Bouret²

Affiliations

The Saban Research Institute, Developmental Neuroscience Program, Children’s Hospital Los Angeles, University of Southern California, Los Angeles, California, USA
University Lille, Inserm, CHU Lille, Laboratory of development and plasticity of the Neuroendocrine brain, Lille Neuroscience & Cognition, Inserm UMR-S1172, Lille, France
Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France
Department of Biological Chemistry, School of Medicine, University of California at Irvine, Irvine, California, USA
Metabolomics Core Facility, Max Planck Institute for Biology of Ageing, Cologne, Germany
Department of Bioinformatics and Genomics, College of Computing and Informatics, University of North Carolina Charlotte, Charlotte, North Carolina, USA
Center for Endocrinology, Diabetes and Metabolism, Children’s Hospital Los Angeles, University of Southern California, Los Angeles, California, USA

#NatMetabPicks | In @JCI_insight, led by @SebastienBouret (@neuroendolille):

Male offspring from dams exposed to low calorie #sweeteners show metabolic deregulation, in part due to rewiring of hypothalamic circuits & changes in the gut #microbiome.

https://insight.jci.org/articles/view/156397…

2023-05-01

Microbial metabolite linked to consequences of perinatal low-calorie sweetener exposure: https://buff.ly/3pSvsFZ
@SebastienBouret @yangyang7079 @BelfoulAmine
@Inserm
#Metabolism #Neuroscience

2023-05-25

We need to fix our sweet tooth! Still, this study only looked at stevia and aspartame. Would be great to look at more sugar substitutes…

2023-04-05

Proud to have the latest paper of @yangyang7079 @BelfoulAmine and collaborators published in @JCI_insight
Check it out if you want to know more about the impact of maternal artificial sweeteners consumption on the offspring metabolic health and brain development

2023-05-25

We are happy to share our latest paper in press in ⁦@JCI_insight⁩ on the impact of maternal low-calorie sweeteners (aspartame, stevia) consumption on the offsprings’ neuronal development and metabolic outcomes https://insight.jci.org/articles/view/156397…

2023-04-05

very interesting that these sweeteners may change some pancreatic processes?

2023-04-05

This is scary and people need to be educated.

2023-04-06

cancer-and-disease

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Carcinogenesis

The environmental carcinogen benzo[a]pyrene regulates epigenetic reprogramming and metabolic rewiring in a two-stage mouse skin carcinogenesis model.

2023-04-26

PubMed:37100755; DOI:10.1093/carcin/bgad024

Md Shahid Sarwar¹, Christina N Ramirez¹, Hsiao-Chen Dina Kuo¹, Pochung Chou¹, Renyi Wu¹, Davit Sargsyan¹, Yuqing Yang¹, Ahmad Shannar¹, Rebecca Mary Peter¹, Ran Yin¹, Yujue Wang², Xiaoyang Su², Ah-Ng Kong¹

Affiliations

Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Metabolomics Shared Resource, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA

International journal of molecular sciences

AI-Predicted mTOR Inhibitor Reduces Cancer Cell Proliferation and Extends the Lifespan of C. elegans .

2023-04-25

PubMed:37175557; DOI:10.3390/ijms24097850

Tinka Vidovic¹, Alexander Dakhovnik², Oleksii Hrabovskyi³, Michael R MacArthur⁴, Collin Y Ewald²

Affiliations

Tinka Therapeutics, Fra Ivana Rozica 7, 21276 Vrgorac, Croatia
Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, CH-8603 Schwerzenbach, Switzerland
Palladin Institute of Biochemistry of the NAS of Ukraine, 02000 Kyiv, Ukraine
Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA

We used #AI to predict #mTOR inhibitors to promote #healthy #longevity. @tinka_vidovic, @ADakhovnik, @MikeMacArthur8, @ETH_en, #EwaldLab https://doi.org/10.3390/ijms24097850…

2023-04-26

our new paper is out, enjoy reading
https://mdpi.com/1422-0067/24/9/7850…
#longevity, #mTOR, #rapamycin, #lifespan, #geroprotectors

2023-04-25

human-health

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The Journal of clinical investigation

Hepatocyte SREBP signaling mediates clock communication within the liver.

2023-04-17

PubMed:37066875; DOI:10.1172/JCI163018

Dongyin Guan¹, Hosung Bae², Dishu Zhou¹, Ying Chen¹, Chunjie Jiang¹, Cam Mong La¹, Yang Xiao³, Kun Zhu³, Wenxiang Hu³, Trang Minh Trinh³, Panpan Liu¹, Ying Xiong³, Bishuang Cai⁴, Cholsoon Jang², Mitchell A Lazar³

Affiliations

Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Department of Biological Chemistry, University of California Irvine, Irvine, California, USA
Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Glad to share our new publication. JCI – Hepatocyte SREBP signaling mediates clock communication within the liver https://jci.org/articles/view/163018#.ZD3ae217SCQ.twitter…. Thanks to all contributors @HosungBae @xyele2003 @KunZhu4 @flyfoxinwood @cholsoon_jang @MitchLazar1 and other colleagues.

2023-04-17

kedalionlabs.com

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