The tumor microenvironment (TME) is the environment around a tumor, including the surrounding blood vessels, immune cells, fibroblasts, signaling molecules and the extracellular matrix (ECM). The tumor and the surrounding microenvironment are closely related and interact constantly. Tumors can influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing peripheral immune tolerance, while the immune cells in the microenvironment can affect the growth and evolution of cancerous cells. Wikipedia (CC BY-SA 3.0)
2023 Articles
33 609 articles
The molecular dialogue between the tumor cells and fibroblasts
- Ramesh Butti, Gopal C Kundu, Ramesh Butti, …, Gopal C Kundu, Ramesh Butti, Gopal C Kundu
- Oncotarget, 10.18632/oncotarget.28405
Niche tension controls exosome production
- Toni Renee Dawson, Toni Renee Dawson, Toni Renee Dawson, …, Alissa Margaret Weaver, Toni Renee Dawson, Alissa Margaret Weaver
- Nat Cell Biol, 10.1038/s41556-023-01088-x
An unexpected pathway to polyamines in pancreatic cancer
- Dominik Awad, Costas A Lyssiotis, Dominik Awad, …, Costas A Lyssiotis, Dominik Awad, Costas A Lyssiotis
- Mol Cell, 10.1016/j.molcel.2023.05.014
How nearby nutrients shape tumor growth
- Nada Kalaany, Nada Kalaany, Nada Kalaany
- Elife, 10.7554/elife.89825
Bypassing the cytokine sink: IL-2-independent IL-2 receptor signaling
- Tim Luetkens, Tim Luetkens, Tim Luetkens, …, Tim Luetkens, Tim Luetkens, Tim Luetkens
- Mol Ther, 10.1016/j.ymthe.2023.07.007
Lysine metabolism at the nexus of crotonylation and tumor immunity
- Fangchao Wei, Jason W Locasale
- Cell Res, 10.1038/s41422-023-00841-z
Drug-Tolerant Persister Cells After EGFR Tyrosine Kinase Inhibitor Treatment: Their Origin and the Influences From the Tumor Microenvironment
- Hiromichi Ebi, Hiromichi Ebi, Hiromichi Ebi
- J Thorac Oncol, 10.1016/j.jtho.2022.12.010
Glutarate tunes T cell fate
- Francisco Yanqui-Rivera, Christiane A Opitz
- Nat Metab, 10.1038/s42255-023-00878-9
Age-induced changes in lung microenvironment: from melanoma dormancy to outgrowth
- Juan Jin, Li Li, Juan Jin, …, Juan Jin, Li Li, Caiyun Fu
- Signal Transduct Target Ther, 10.1038/s41392-022-01303-5
Editorial: The role of STAT3 signaling pathway in tumor progression
- Nan-Shan Chang, Kenneth Kw To, Yih-Cherng Liou, …, Kenneth Kw To, Yih-Cherng Liou, Yi-Jia Li
- None, 10.3389/fonc.2023.1151862
2022 Articles
3 719 articles
Engineering time-controlled immunotherapy
- Emanuel Salazar-Cavazos, Grégoire Altan-Bonnet, Emanuel Salazar-Cavazos, …, Grégoire Altan-Bonnet, Emanuel Salazar-Cavazos, Grégoire Altan-Bonnet
- Science, 10.1126/science.adf5318
Bicarbonate transport as a vulnerability in pancreatic cancer
- Li Qiang, Li Qiang, Li Qiang, …, Stephanie K Dougan, Li Qiang, Stephanie K Dougan
- Nat Cancer, 10.1038/s43018-022-00492-w
Tipping the balance: New insights into stromal regulation of cancer
- Joana Leitão Castro, Janine Terra Erler, Joana Leitão Castro, Janine Terra Erler, Joana Leitão Castro, Janine Terra Erler
- Cancer Cell, 10.1016/j.ccell.2022.11.011
Pancreatic stellate cells exploit Wnt/β-catenin/TCF7-mediated glutamine metabolism to promote pancreatic cancer cells growth
- Hangqi Liu, Hui Zhang, Xiaoqian Liu, …, Huanwen Wu, Menghua Dai, Zhiyong Liang
- Cancer Lett, 10.1016/j.canlet.2022.216040
Assessing the Immune Regulatory Role of Metabolites In Vitro
- Sarah McPhedran, Junu Choe, Sarah MacPherson, …, Vanessa Chan, Marisa K Kilgour, Julian J Lum
- Methods Mol Biol, 10.1007/978-1-0716-2914-7_8
Exosomal miR-485-3p derived from pancreatic ductal epithelial cells inhibits pancreatic cancer metastasis through targeting PAK1
- Mingzhe Li, Jiaxin Zhou, Zhengkui Zhang, …, Xiaodong Tian, Zebin Mao, Yinmo Yang
- Chin Med J (Engl), 10.1097/cm9.0000000000002154
SOX2-high cancer cells exhibit an aggressive phenotype, with increases in stemness, proliferation and invasion, as well as higher metabolic activity and ATP production
- Marta Mauro-Lizcano, Federica Sotgia, Michael P Lisanti, …, Marta Mauro-Lizcano, Federica Sotgia, Michael P Lisanti
- Aging (Albany NY), 10.18632/aging.204452
Dickkopf-1 drives tumor immune evasion by inducing PD-L1 expression in hepatocellular carcinoma
- Ruo-Han Yang, Jia Qin, Jin-Lan Cao, …, Meng-Qing Wang, Dong Fang, Song-Qiang Xie
- Biochem Pharmacol, 10.1016/j.bcp.2022.115378
NLRP3 in tumor-associated macrophages predicts a poor prognosis and promotes tumor growth in head and neck squamous cell carcinoma
- Lei Chen, Shu-Cheng Wan, Liang Mao, …, Cong-Fa Huang, Lin-Lin Bu, Zhi-Jun Sun
- Cancer Immunol Immunother, 10.1007/s00262-022-03357-4
A novel regulator in cancer initiation and progression: long noncoding RNA SHNG9
- Mingxing Zhao, Yang Zhang, Mingxing Zhao, …, Mingxing Zhao, Yang Zhang, Shen Shen
- Clin Transl Oncol, 10.1007/s12094-022-03060-x