Ribosomes (/ˈraɪbəˌsoʊm, -boʊ-/) are macromolecular machines, found within all cells, that perform biological protein synthesis (mRNA translation). Ribosomes link amino acids together in the order specified by the codons of messenger RNA (mRNA) molecules to form polypeptide chains. Ribosomes consist of two major components: the small and large ribosomal subunits. Each subunit consists of one or more ribosomal RNA (rRNA) molecules and many ribosomal proteins (RPs or r-proteins). The ribosomes and associated molecules are also known as the translational apparatus. Wikipedia (CC BY-SA 3.0)
📺 Subchannels:
2023 Articles
8 224 articles
Fix it, don’t trash it: Ribosome maintenance by chaperone-mediated repair of damaged subunits
- Silvan Spiri, Gloria Ann Brar, Silvan Spiri, …, Gloria Ann Brar, Silvan Spiri, Gloria Ann Brar
- Mol Cell, 10.1016/j.molcel.2023.04.006
Decoding a ribosome uncertainty
- Olivier Duss, Rainer Nikolay, Matthew L Kraushar, …, Olivier Duss, Rainer Nikolay, Matthew L Kraushar
- Trends Genet, 10.1016/j.tig.2023.06.001
Ready, steady, go: Rapid ribosomal scanning to reach start codons
- Helge Paternoga, Daniel N Wilson, Helge Paternoga, …, Daniel N Wilson, Helge Paternoga, Daniel N Wilson
- Mol Cell, 10.1016/j.molcel.2022.12.008
Optimized protocol for quantifying 5′ UTR-mediated translation initiation in S. cerevisiae using direct analysis of ribosome targeting
- Cole J T Lewis, Rachel O Niederer, Ritam Neupane, …, Rachel O Niederer, Ritam Neupane, Wendy V Gilbert
- STAR Protoc, 10.1016/j.xpro.2022.101862
Visualization of translation reorganization upon persistent collision stress in mammalian cells
- Juliette Fedry, Joana Silva, Mihajlo Vanevic, …, Amédée des Georges, William Faller, Friedrich Förster
- bioRxiv : the preprint server for biology, 10.1101/2023.03.23.533914
Tethered Ribosomes: Toward the Synthesis of Nonproteinogenic Polymers in Bacteria
- Andreea Stan, Clemens Mayer, Andreea Stan, …, Clemens Mayer, Andreea Stan, Clemens Mayer
- Chembiochem, 10.1002/cbic.202200578
Chloramphenicol Derivatization in Its Primary Hydroxyl Group with Basic Amino Acids Leads to New Pharmacophores with High Antimicrobial Activity
- Artemis Tsirogianni, Georgia G Kournoutou, Maria Mpogiatzoglou, …, Maria Mpogiatzoglou, George Dinos, Constantinos M Athanassopoulos
- None, 10.3390/antibiotics12050832
Structural basis for reduced ribosomal A-site fidelity in response to P-site codon-anticodon mismatches
- HaAn Nguyen, EricD Hoffer, CrystalE Fagan, …, Crystal E Fagan, Tatsuya Maehigashi, Christine M Dunham
- J Biol Chem, 10.1016/j.jbc.2023.104608
Structural basis for reduced ribosomal A-site fidelity in response to P-site codon-anticodon mismatches
- Ha An Nguyen, Eric D Hoffer, Crystal E Fagan, …, Crystal E Fagan, Tatsuya Maehigashi, Christine M Dunham
- bioRxiv : the preprint server for biology, 10.1101/2023.01.28.526049
2022 Articles
806 articles
Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate no-go decay
- Shota Tomomatsu, Atsuya Watanabe, Petr Tesina, …, Yoshitaka Matsuo, Roland Beckmann, Toshifumi Inada
- Nucleic Acids Res, 10.1093/nar/gkac1172
Ratchet, swivel, tilt and roll: a complete description of subunit rotation in the ribosome
- Asem Hassan, Sandra Byju, Frederico Campos Freitas, …, Ronaldo Junio de Oliveira, Christine M Dunham, Paul C Whitford
- Nucleic Acids Res, 10.1093/nar/gkac1211
Insights into the molecular mechanism of translation inhibition by the ribosome-targeting antibiotic thermorubin
- Madhura N Paranjpe, Valeria I Marina, Aleksandr A Grachev, …, Andrey L Konevega, Yury S Polikanov, Matthieu G Gagnon
- Nucleic Acids Res, 10.1093/nar/gkac1189
IRES-mediated translation in bacteria
- Sarah Takallou, Nathalie Puchacz, Danielle Allard, …, Mohammad Reza Nokhbeh, Bahram Samanfar, Ashkan Golshani
- Biochem Biophys Res Commun, 10.1016/j.bbrc.2022.12.022
Transcription-translation coupling: Traveling a road under construction
- Stefan Klumpp, Stefan Klumpp, Stefan Klumpp, Stefan Klumpp, Stefan Klumpp, Stefan Klumpp
- Biophys J, 10.1016/j.bpj.2022.12.006
Impaired ribosome-associated quality control of C9orf72 arginine-rich dipeptide-repeat proteins
- Ashley P Viera Ortiz, Gregory Cajka, Olamide A Olatunji, …, Bailey Mikytuck, Ophir Shalem, Edward B Lee
- Brain, 10.1093/brain/awac479
Specific mechanisms of translation initiation in higher eukaryotes: the eIF4G2 story
- Ekaterina D Shestakova, Victoria V Smirnova, Ivan N Shatsky, …, Victoria V Smirnova, Ivan N Shatsky, Ilya M Terenin
- RNA, 10.1261/rna.079462.122
Modeling the ribosome as a bipartite graph
- Laurie E Calvet, Laurie E Calvet, Laurie E Calvet, Laurie E Calvet, Laurie E Calvet
- PLoS One, 10.1371/journal.pone.0279455
Eukaryotic translation initiation factor eIF4G2 opens novel paths for protein synthesis in development, apoptosis and cell differentiation
- Yudi Liu, Jiuwei Cui, Andrew R Hoffman, …, Jiuwei Cui, Andrew R Hoffman, Ji-Fan Hu
- Cell Prolif, 10.1111/cpr.13367
Initiation at AUGUG and GUGUG sequences can lead to translation of overlapping reading frames in E. coli
- Maximilian P Kohl, Maria Kompatscher, Nina Clementi, …, Nina Clementi, Lena Holl, Matthias D Erlacher
- Nucleic Acids Res, 10.1093/nar/gkac1175