Inspired by: David M. Sabatini
Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumor (PEComa). It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants. It is a mechanistic target of rapamycin kinase (mTOR) inhibitor that inhibits activation of T cells and B cells by reducing their sensitivity to interleukin-2 (IL-2). Wikipedia (CC BY-SA 3.0)
2023 Articles
31 781 articles
mTORC1 implicated in Still’s disease and MAS
- Sarah Onuora, Sarah Onuora, Sarah Onuora, Sarah Onuora, Sarah Onuora
- Nat Rev Rheumatol, 10.1038/s41584-023-00908-6
Effects of STAU1/staufen1 on autophagy in neurodegenerative diseases
- Stefan M Pulst, Daniel R Scoles, Sharan Paul, …, Stefan M Pulst, Daniel R Scoles, Sharan Paul
- Autophagy, 10.1080/15548627.2023.2169306
PI5P4Kα: a target in prostate cancer?
- Louise Stone, Louise Stone, Louise Stone, Louise Stone, Louise Stone
- Nat Rev Urol, 10.1038/s41585-023-00759-6
Mitochondrial fission fueled by fasting
- Wei Wong, Wei Wong, Wei Wong
- Sci Signal, 10.1126/scisignal.adk1008
Correction: RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling
- Chengyun Xu, Jing Zhang, Yizhong Bao, …, Bo Ma, Ximei Wu, Genxiang Mao
- Mol Med, 10.1186/s10020-023-00699-2
The translation m(o)TOR that propels regeneration
- Eytan Zlotorynski
- Nat Rev Mol Cell Biol, 10.1038/s41580-023-00657-0
GATOR2 rings GATOR1 to speak to mTORC1
- Umakant Sahu, Issam Ben-Sahra, Umakant Sahu, …, Issam Ben-Sahra, Umakant Sahu, Issam Ben-Sahra
- Mol Cell, 10.1016/j.molcel.2022.12.011
Transcriptional regulation of autophagy by chromatin remodeling complex and histone variant
- Xin Li, Shanshan Wang, Xilan Yu, …, Shanshan Wang, Xilan Yu, Shanshan Li
- Autophagy, 10.1080/15548627.2023.2200352
Transcriptional response of endometrial cells to Insulin, cultured using microfluidics
- Soo Young Baik, Alisha Maini, Haidee Tinning, …, Daman Adlam, Peter T Ruane, Niamh Forde
- Reprod Fertil, 10.1530/raf-21-0120
2022 Articles
3 610 articles
mTOR inhibitors in a patient with lupus nephritis; why not?
- Raquel Berzal, Beatriz Agredano, Marco Gil, MarĂa Galindo, Enrique Morales
- Nefrologia (Engl Ed), 10.1016/j.nefroe.2022.03.009
mTORC1 takes control of lysosomal lipid breakdown
- Laura Tribouillard, Laura Tribouillard, Laura Tribouillard, …, Mathieu Laplante, Laura Tribouillard, Mathieu Laplante
- Nat Metab, 10.1038/s42255-022-00702-w
Queueing theory model of mTOR complexes’ impact on Akt-mediated adipocytes response to insulin
- Sylwester M Kloska, Krzysztof PaĆczyĆski, Tomasz Marciniak, …, Paul H Davis, Ghada A Soliman, Tadeusz A Wysocki
- PLoS One, 10.1371/journal.pone.0279573
Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis
- Pranetha Baskaran, Simeon R Mihaylov, Elin Vinsland, …, Andrew R Tee, Jernej Murn, Joseph M Bateman
- J Biol Chem, 10.1016/j.jbc.2022.102788
Immunohistochemical Techniques for Phosphoproteins
- Berenice L Sanz Ressel, Alfredo A Molinolo, Berenice L Sanz Ressel, Alfredo A Molinolo, Berenice L Sanz Ressel, Alfredo A Molinolo
- Methods Mol Biol, 10.1007/978-1-0716-2811-9_17
mTOR Signaling Network in Cell Biology and Human Disease
- Jane J Yu, Elena A Goncharova, Jane J Yu, …, Elena A Goncharova, Jane J Yu, Elena A Goncharova
- Int J Mol Sci, 10.3390/ijms232416142
Ring domains are essential for GATOR2-dependent mTORC1 activation
- Cong Jiang, Xiaoming Dai, Shaohui He, …, Ping Wang, Jianru Xiao, Wenyi Wei
- Mol Cell, 10.1016/j.molcel.2022.11.021
Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics
- Zofia Chrienova, David Rysanek, Patrik Oleksak, …, Kamil Kuca, Zdenek Hodny, Eugenie Nepovimova
- None, 10.3389/fnagi.2022.1048260
Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors
- G Leslie Burnett, Yu C Yang, James B Aggen, …, Mallika Singh, Jacqueline A M Smith, Adrian L Gill
- J Med Chem, 10.1021/acs.jmedchem.2c01658
Ras-mediated activation of mTORC2 promotes breast epithelial cell migration and invasion
- Shannon E Collins, Mollie E Wiegand, Alyssa N Werner, …, Douglas J Swango, Ghassan Mouneimne, Pascale G Charest
- Mol Biol Cell, 10.1091/mbc.e22-06-0236