In organisms, methylglyoxal is formed as a side-product of several metabolic pathways. Methylglyoxal mainly arises as side products of glycolysis involving glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. It is also thought to arise via the degradation of acetone and threonine. Wikipedia (CC BY-SA 3.0)
2023 Articles
293 articles
The secret life of lactate: A novel cell-cycle regulatory mechanism
- Ahmad A Cluntun, Jared Rutter, Ahmad A Cluntun, Jared Rutter, Ahmad A Cluntun, Jared Rutter
- Cell Metab, 10.1016/j.cmet.2023.04.006
Reconsidering the role of protein glycation in disease
- Marissa N Trujillo, Marissa N Trujillo, Marissa N Trujillo, …, James J Galligan, Marissa N Trujillo, James J Galligan
- Nat Chem Biol, 10.1038/s41589-023-01382-7
Methylglyoxal suppresses microglia inflammatory response through NRF2-IκBζ pathway
- Shu-Li Wei, Ying Yang, Wei-Yue Si, …, Ruo-Nan Duan, Rui-Sheng Duan, Chun-Lin Yang
- Redox Biol, 10.1016/j.redox.2023.102843
Pyridoxamine prevents increased atherosclerosis by intermittent methylglyoxal spikes in the aortic arches of ApoE-/- mice
- Nordin M J Hanssen, Chris Tikellis, Raelene J Pickering, …, Andrew J Murphy, Merlin C Thomas, Casper G Schalkwijk
- Biomed Pharmacother, 10.1016/j.biopha.2022.114211
Resistance to Gemcitabine in Pancreatic Cancer Is Connected to Methylglyoxal Stress and Heat Shock Response
- Rebekah Crake, Imène Gasmi, Jordan Dehaye, …, Olivier Peulen, Jean-Luc Van Laethem, Akeila Bellahcène
- Cells, 10.3390/cells12101414
Strategies for uncovering stable isotope tracing patterns between cell populations
- Sarah MacPherson, Kyle D Duncan, David R Goodlett, Julian J Lum
- Curr Opin Biotechnol, 10.1016/j.copbio.2023.102991
Methylglyoxal-induced neurotoxic effects in primary neuronal-like cells transdifferentiated from human mesenchymal stem cells: Impact of low concentrations
- Teresa Coccini, Azzurra Schicchi, Carlo Alessandro Locatelli, …, Sara Negri, Elena Grignani, Uliana De Simone
- J Appl Toxicol, 10.1002/jat.4515
Lactate-Mediated Signaling in the Brain-An Update
- Barbara Vaccari-Cardoso, Maria Antipina, Anja G Teschemacher, …, Maria Antipina, Anja G Teschemacher, Sergey Kasparov
- None, 10.3390/brainsci13010049
Immunometabolism at the basis of health and disease; an editorial
- Jan Van den Bossche, Tiffany Horng, Dylan G Ryan, …, Jan Van den Bossche, Tiffany Horng, Dylan G Ryan
- Biochim Biophys Acta Mol Basis Dis, 10.1016/j.bbadis.2023.166715
Parkinsonism-Associated Protein DJ-1 Is an Antagonist, Not an Eraser, for Protein Glycation
- Qingzeng Gao, Jeremiah W Jacob-Dolan, Rebecca A Scheck, …, Qingzeng Gao, Jeremiah W Jacob-Dolan, Rebecca A Scheck
- Biochemistry, 10.1021/acs.biochem.3c00028
2022 Articles
26 articles
Widespread, Reversible Cysteine Modification by Methylglyoxal Regulates Metabolic Enzyme Function
- John S Coukos, Chris W Lee, Kavya S Pillai, …, Kavya S Pillai, Kimberly J Liu, Raymond E Moellering
- ACS Chem Biol, 10.1021/acschembio.2c00727
Loss of glyoxalase 2 alters the glucose metabolism in zebrafish
- Christoph Tobias Tabler, Elisabeth Lodd, Katrin Bennewitz, …, Julia Szendroedi, Peter Paul Nawroth, Jens Kroll
- Redox Biol, 10.1016/j.redox.2022.102576
A novel inhibitor of PGK1 suppresses the aerobic glycolysis and proliferation of hepatocellular carcinoma
- Mingfeng Li, Aotong Zhang, Xin Qi, …, Xin Qi, Rilei Yu, Jing Li
- Biomed Pharmacother, 10.1016/j.biopha.2022.114115
Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
- Jinit Masania, Patrick Wijten, Susanne Keipert, …, Susanne Klaus, Naila Rabbani, Paul J Thornalley
- Redox Biol, 10.1016/j.redox.2022.102574
H3K27 acetylation activated long noncoding RNA RP11-162G10.5 promotes breast cancer progression via the YBX1/GLO1 axis
- Ning Xie, Ruihuang Zhang, Zhuofei Bi, …, Hai Hu, Ying Xu, Herui Yao
- Cell Oncol (Dordr), 10.1007/s13402-022-00756-8
Dibutyl phthalate affects insulin synthesis and secretion by regulating the mitochondrial apoptotic pathway and oxidative stress in rat insulinoma cells
- Ruoru Yang, Jianheng Zheng, Jin Qin, …, Shuguang Li, Bo Chen, Ruihua Dong
- Ecotoxicol Environ Saf, 10.1016/j.ecoenv.2022.114396
Differences in junction-associated gene expression changes in three rat models of diabetic retinopathy with similar neurovascular phenotype
- Matthias Kolibabka, Marcus Dannehl, Kübra Oezer, …, Andrea Schlotterer, Yuxi Feng, Hans-Peter Hammes
- Neurobiol Dis, 10.1016/j.nbd.2022.105961
Emerging Nonpharmacologic Interventions to Treat Diabetic Peripheral Neuropathy
- Jonathan Enders, Daniel Elliott, Douglas Wright, …, Jonathan Enders, Daniel Elliott, Douglas E Wright
- Antioxid Redox Signal, 10.1089/ars.2022.0158
A Selective Fluorescent l-Lactate Biosensor Based on an l-Lactate-Specific Transcription Regulator and Förster Resonance Energy Transfer
- Xianzhi Xu, Rong Xu, Shuang Hou, …, Ping Xu, Chao Gao, Cuiqing Ma
- Biosensors (Basel), 10.3390/bios12121111
Advantages of pyruvate-based fluids in preclinical shock resuscitation-A narrative review
- Fang-Qiang Zhou, Fang-Qiang Zhou
- None, 10.3389/fphys.2022.1027440