Arnold World January 2023

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Metabolic engineering

Comparative study of two Saccharomyces cerevisiae strains with kinetic models at genome-scale.

2023-01-02

PubMed:36603705; DOI:10.1016/j.ymben.2023.01.001

Mengqi Hu¹, Hoang V Dinh¹, Yihui Shen², Patrick F Suthers¹, Charles J Foster³, Catherine M Call², Xuanjia Ye⁴, Jimmy Pratas², Zia Fatma⁵, Huimin Zhao⁶, Joshua D Rabinowitz², Costas D Maranas⁷

Affiliations

Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA; DOE Center for Advanced Bioenergy and Bioproducts Innovation, USA
Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, 08544, USA; DOE Center for Advanced Bioenergy and Bioproducts Innovation, USA
Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA
Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA
Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA; DOE Center for Advanced Bioenergy and Bioproducts Innovation, USA
Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA; Department of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA; DOE Center for Advanced Bioenergy and Bioproducts Innovation, USA
Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA; DOE Center for Advanced Bioenergy and Bioproducts Innovation, USA.

evolutionary-engineering–proteins

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ACS central science

Comprehensive Structure-Activity Relationship Studies of Cepafungin Enabled by Biocatalytic C-H Oxidations.

2023-01-27

PubMed:36844499; DOI:10.1021/acscentsci.2c01219

Alexander Amatuni¹, Anton Shuster¹, Daniel Abegg², Alexander Adibekian², Hans Renata³

Affiliations

Skaggs Doctoral Program in the Chemical and Biological Sciences, Scripps Research, La Jolla, California 92037, United States
Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607, United States
Department of Chemistry, BioScience Research Collaborative, Rice University, Houston, Texas 77005, United States

This work has now been officially published in @ACSCentSci, kudos to first author Alex Amatuni for driving this project to completion and thanks again to @AdibekianG for a productive collab!
https://pubs.acs.org/doi/10.1021/acscentsci.2c01219…

2023-01-30

Journal of the American Chemical Society

Asymmetric C -Alkylation of Nitroalkanes via Enzymatic Photoredox Catalysis.

2023-01-06

PubMed:36608280; DOI:10.1021/jacs.2c12197

Haigen Fu¹, Tianzhang Qiao¹, Jose M Carceller¹, Samantha N MacMillan¹, Todd K Hyster¹

Affiliations

Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14850, United States

New Year New Nitroalkanes! Check out our latest in @J_A_C_S. Great work lead by the dream duo Haigen and @TianzhangQ with some critical help from Jose and Sam!Congrats you Hystars https://pubs.acs.org/doi/full/10.1021/jacs.2c12197….

2023-01-06

Asymmetric C-Alkylation of Nitroalkanes via Enzymatic Photoredox Catalysis @HysterLab
@CornellChem @TotalSyntheses #Alkylation #Nitroalkanes #Photoredox #Catalysis

2023-01-08

Nice one! Proud of alum @TianzhangQ!

2023-01-06

ACS chemical biology

A Spirobicyclo[3.1.0]Terpene from the Investigation of Sesquiterpene Synthases from Lactarius deliciosus .

2023-01-03

PubMed:36594743; DOI:10.1021/acschembio.2c00760

Choon Boon Cheong¹, GuangRong Peh¹, Yifeng Wei², Rehka T², Ee Lui Ang², Huimin Zhao³, Congqiang Zhang², Yee Hwee Lim¹

Affiliations

Institute of Sustainability for Chemicals, Energy and Environment, A*STAR, Singapore 138665, Singapore
Singapore Institute of Food and Biotechnology Innovation, A*STAR, Singapore 138669, Singapore
Department of Chemical and Biomolecular Engineering, Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States

evolution-physiology

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Nature

Molecular fate-mapping of serum antibody responses to repeat immunization.

2023-01-16

PubMed:36646114; DOI:10.1038/s41586-023-05715-3

Ariën Schiepers¹, Marije F L van ‘t Wout¹, Allison J Greaney², Trinity Zang³, Hiromi Muramatsu⁴, Paulo J C Lin⁵, Ying K Tam⁵, Luka Mesin¹, Tyler N Starr², Paul D Bieniasz³, Norbert Pardi⁴, Jesse D Bloom², Gabriel D Victora⁶

Affiliations

Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA
Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Acuitas Therapeutics, Vancouver, British Columbia, Canada
Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.

At AAI, just listened to a fantastic talk by @Arien_Schiepers, very elegant new mouse model to understand B cell recruitment to the GC and the original antigenic sin. https://doi.org/10.1038/s41586-023-05715-3… @victora_lab #AAI2023 #immunology2023

2023-05-11

synbio-meteng

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Journal of the American Chemical Society

Sugar-Fueled Dissipative Living Materials.

2023-01-09

PubMed:36623280; DOI:10.1021/jacs.2c11122

Hyuna Jo¹, Serxho Selmani¹, Zhibin Guan¹, Seunghyun Sim¹

Affiliations

Center for Complex and Active Materials, University of California, Irvine, Irvine, California 92697, United States

Sugar-Fueled Dissipative Living Materials @UCIChemistry @UCIrvine #Fuel #Sugar #Living #Materials @sciam @NYT @NYTScience

2023-01-10

human-physiology

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bioRxiv

Fitness effects of mutations to SARS-CoV-2 proteins

2023-01-31

DOI:10.1101/2023.01.30.526314

J. D. Bloom, R. A. Neher

Affiliations

Fred Hutchinson Cancer Research Center

Correct, just means they show up more often in human-transmitted SARS2 than expected given mutation rate, so must be favorably selected.

Cannot distinguish if because of immune escape or transmissibility. But for non-spike mutations probably the latter.

2023-03-26

bioRxiv

Acoustically Targeted Noninvasive Gene Therapy in Large Brain Regions

2023-01-20

DOI:10.1101/2023.01.19.524626

S. Nouraein, V. A. Saenz, H. C. Del Mundo, J. Yiu, J. O. Szablowski

Affiliations

Rice University

How much BBB can you safely open with ultrasound? Turns out nearly all of it. We showed transduction improves when opening volumes go up, made map of transduction efficiency, and noninvasively edited brain’s genome. Lead by 1st-year student @Shinouraein
https://biorxiv.org/content/10.1101/2023.01.19.524626v1…

2023-01-23

kedalionlabs.com

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