Alonosphere April 2023

highlight

⬆️

Nature communications

Damage dynamics and the role of chance in the timing of E. coli cell death.

2023-04-18

PubMed:37072447; DOI:10.1038/s41467-023-37930-x

Yifan Yang¹, Omer Karin², Avi Mayo², Xiaohu Song³, Peipei Chen³, Ana L Santos³, Ariel B Lindner³, Uri Alon⁴

Affiliations

Department of molecular Cell biology, Weizmann Institute of Science, 71600, Rehovot, Israel.
Department of molecular Cell biology, Weizmann Institute of Science, 71600, Rehovot, Israel
Université de Paris – INSERM Unit 1284, Center for Research and Interdisciplinarity (CRI), Paris, F-75004, France
Department of molecular Cell biology, Weizmann Institute of Science, 71600, Rehovot, Israel.

Damage dynamics in individual E. coli cells as they age explains why identical cells die at different times.
Amazingly, damage follows a stochastic equation found also in mice. Aging may be universal in its fundamental dynamics. #qbio #aging

2023-04-24

Genetically identical, but time defies,
In stress, cells in varying demise,
Unclear the origin, stochastic it seems,
Different lifespans, a puzzle of schemes,
Damage dynamics measured, the truth it belies.

Microfluidic device, the key we confide,
635 E. coli cells, dynamics to ride,
Initial conditions, not the main cause,
Damage production rises, breaking the laws,
Stochasticity prevails, as age does provide.

As time marches on, cells align,
Relative damage narrows, a sign,
Deterministic dynamics, they now control,
Erasing the chance, as they patrol,
Lifespan distribution, a tale so fine.

The Lancet. Planetary health

Exploring scenarios for the food system-zoonotic risk interface.

2023-04-05

PubMed:37019573; DOI:10.1016/S2542-5196(23)00007-4

Alon Shepon¹, Tong Wu², Claire Kremen³, Tamar Dayan⁴, Ivette Perfecto⁵, Jessica Fanzo⁶, Gidon Eshel⁷, Christopher D Golden⁸

Affiliations

Department of Environmental Studies, The Porter School of the Environment and Earth Sciences, Tel Aviv University, Tel Aviv, Israel; The Steinhardt Museum of Natural History, Tel Aviv University, Tel Aviv, Israel.
The Natural Capital Project, Stanford University, Stanford, CA, USA
Institute of Resources, Environment and Sustainability, Biodiversity Research Center and Department of Zoology, The University of British Columbia, Vancouver, BC, Canada
The Steinhardt Museum of Natural History, Tel Aviv University, Tel Aviv, Israel; School of Zoology, Tel Aviv University, Tel Aviv, Israel
School for Environment and Sustainability, University of Michigan, Ann Arbor, MI, USA
School of Advanced International Studies, Berman Institute of Bioethics and Bloomberg School of Public Health, Baltimore, MD, USA
Department of Environmental Science, Bard College, Annandale-on-Hudson, NY, USA
Department of Nutrition and Department of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA, USA

Amidst COVID-19’s dread,
Zoonotic spillovers widespread,
At the human-wildlife thread,
Food systems’ role, we must tread,
Preventing risks, a path we’ll thread.

Land use changes take a toll,
Livestock dense, a factor’s role,
Archetypes of food systems whole,
Distinct risk profiles they enroll,
Sustaining health, a vital goal.

Sustainability’s demand,
Prophylactic measures at hand,
Research explores, we understand,
Linking food to risks firsthand,
A safer world, we’ll firmly stand.

bioRxiv

Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota

2023-04-01

DOI:10.1101/2023.03.31.535104

S. Carasso, R. Zaatry, H. Hajjo, D. Kadosh-Kariti, N. Ben-Assa, R. Naddaf, N. Mandelbaum, S. Pressman, Y. Chowers, T. Gefen, K. L. Jeffrey, J. Jofre, M. J. Coyne, L. E. Comstock, I. Sharon, N. Geva-Zatorsky

Affiliations

Department of Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Rappaport Technion Integrated Cancer Cent

Excited to share our new #preprint studying bacterial #DNAinversions in inflammatory bowel diseases #IBD, in patients and mice, with implications on the host #immunesystem. #microbiome #inflammation #bacteriophages 1/8 https://biorxiv.org/cgi/content/short/2023.03.31.535104v1…

2023-04-02

human-physiology

⬆️

Trends in immunology

Autoimmune thyroid diseases as a cost of physiological autoimmune surveillance.

2023-04-13

PubMed:37061365; DOI:10.1016/j.it.2023.03.007

Tomer Milo¹, Yael Korem Kohanim², Yoel Toledano³, Uri Alon⁴

Affiliations

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
Division of Maternal Fetal Medicine, Helen Schneider Women’s Hospital, Rabin Medical Center, Petah Tikva, 4941492 Israel
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel.

Is it possible that Graves’ and Hashimoto’s, two opposite autoimmune diseases of the thyroid, have the same origin?

We suggest they do and that their origin even has an important physiological role for all of us

https://cell.com/trends/immunology/fulltext/S1471-4906(23)00051-0…
@TrendsImmuno

2023-04-19

In thyroid’s domain, so profound,_x000D_
Autoimmune diseases, both renowned._x000D_
GD and HT they’re called,_x000D_
Hyper and hypo enthralled,_x000D_
Linked in ways that still astound!_x000D_
_x000D_
Autoimmune surveillance in play,_x000D_
To control hormones that stray._x000D_
T cells act with great might,_x000D_
To eliminate the fight,_x000D_
Antibodies rise, in this display!_x000D_
_x000D_
Similarities, despite their divide,_x000D_
Incidence and risk factors they hide._x000D_
Threatening mutants they dread,_x000D_
With antibodies widespread,_x000D_
GD and HT, forever tied!

Cell reports

Emergence of division of labor in tissues through cell interactions and spatial cues.

2023-04-21

PubMed:37086403; DOI:10.1016/j.celrep.2023.112412

Miri Adler¹, Noa Moriel², Aleksandrina Goeva³, Inbal Avraham-Davidi³, Simon Mages⁴, Taylor S Adams⁵, Naftali Kaminski⁵, Evan Z Macosko⁶, Aviv Regev⁷, Ruslan Medzhitov⁸, Mor Nitzan⁹

Affiliations

Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Tananbaum Center for Theoretical and Analytical Human Biology, Yale University School of Medicine, New Haven, CT, USA
School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA
Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Gene Center and Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany
Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA
Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Massachusetts General Hospital, Department of Psychiatry, Boston, MA, USA
Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Tananbaum Center for Theoretical and Analytical Human Biology, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel; Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem, Israel; Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.

Finally out! “Emergence of division of labor in tissues through cell interactions and spatial cues”
Kudos Drs. Adler, Medzhitov Nitzan & team!
Very relevant lung fibroblasts & #CurePF4All.
Also, I think a is due @MiriAdler @RMedzhitov @mor_nitzan?
https://cell.com/cell-reports/fulltext/S2211-1247(23)00423-0…

2023-04-26

Cool use of inverse Pareto theory to understand division of labor in tissues.

https://pubmed.ncbi.nlm.nih.gov/37086403/

2023-05-03

Very excited to share our work on tissue division of labor that is guided by cell interactions and spatial cues, a joint effort with @moriel_noa, @AleksGoeva, @mor_nitzan, and others (see below) along with my inspiring mentors @RMedzhitov and #AvivRegev.

2023-04-27

Leveraging cell-cell interactions to predict the spatial arrangement of cells based on their gene expression profile in the presence of external morphogen gradients

2023-05-03

_x000D_
In multicellular life’s grand scheme,_x000D_
Cells have functions that might not team._x000D_
Division of labor’s the key,_x000D_
To perform tasks differently,_x000D_
A computational dream, it would seem._x000D_
_x000D_
Tissue environments may guide,_x000D_
Or self-organization takes pride._x000D_
Through trade-offs, they’re optimized,_x000D_
Expression patterns realized,_x000D_
Cell interactions, far and wide._x000D_
_x000D_
With ligand-receptor networks in sight,_x000D_
Specialist cells, their roles ignite._x000D_
Using RNA sequencing, we trace,_x000D_
Stromal, epithelial, immune cell’s embrace,_x000D_
Characterizing complexity’s grace!

Molecular therapy. Methods & clinical development

OCT4 induces long-lived dedifferentiated kidney progenitors poised to redifferentiate in 3D kidney spheroids.

2023-04-23

PubMed:37214315; DOI:10.1016/j.omtm.2023.04.005

Dorit Omer¹, Osnat Cohen Zontag¹, Yehudit Gnatek¹, Orit Harari-Steinberg¹, Oren Pleniceanu¹, Michael Namestnikov¹, Ayelet-Hashahar Cohen², Malka Nissim-Rafinia², Gal Tam³, Tomer Kalisky³, Eran Meshorer², Benjamin Dekel¹

Affiliations

Pediatric Stem Cell Research Institute, Edmond & Lily Safra Children’s Hospital, Sheba Medical Center, Tel Hashomer 5262000, Israel
Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, Israel
Faculty of Engineering and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan 5290002, Israel

OCT4 induces long-lived dedifferentiated kidney progenitors poised to re-differentiation in 3D-kidney spheroids http://dlvr.it/SmvgHf #MTMCD

2023-04-22

Neuroepidemiology

Is there horizontal transmission of Creutzfeldt-Jakob disease?

2023-04-12

PubMed:37044081; DOI:10.1159/000530407

Yacov Balash, Esther Kahana, Amos D Korczyn, Meir Wolker, Hadeel Nabal, Emilia Anis, Hanna Rosenmann, Ron Milo

Affiliations

eLife

Boosting in the age of Omicron.

2023-04-17

PubMed:37066867; DOI:10.7554/eLife.87358

Alex Sigal¹

Affiliations

Africa Health Research Institute, Durban, South Africa

In this Insight Article, Alex Sigal delves into the ineffectiveness of a third dose of CoronaVac against the Omicron variant, and what this research means for controlling the next pandemic. https://elifesciences.org/articles/87358?utm_source=twitter&utm_medium=social&utm_campaign=organic_insights…

2023-04-21

algo

⬆️

Bioinformatics advances

RBAtools: a programming interface for Resource Balance Analysis models.

2023-04-22

PubMed:37179703; DOI:10.1093/bioadv/vbad056

Oliver Bodeit¹, Inès Ben Samir¹, Jonathan R Karr², Anne Goelzer¹, Wolfram Liebermeister¹

Affiliations

MaIAGE, Université Paris-Saclay, INRAE, 78350 Jouy-en-Josas, France
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

RBAtools: a programming interface for Resource Balance Analysis models by Oliver Bodeit, Inès Ben Samir, Jonathan R Karr, Anne Goelzer, Wolfram Liebermeister https://doi.org/10.1093/bioadv/vbad056… edited by @inanna_nalytica

2023-04-26

kedalionlabs.com

Leave a Reply Cancel reply