A Novel Pathway for Biosynthesis of the Herbicidal Phosphonate Natural Product Phosphonothrixin Is Widespread in Actinobacteria
- Luke Bown, Ryuichi Hirota, Michelle N Goettge, …, Wilfred A van der Donk, Kou-San Ju, William W Metcalf
- J Bacteriol, 10.1128/jb.00485-22
A Novel Biosynthetic Gene Cluster Across the Pantoea Species Complex Is Important for Pathogenicity in Onion
- Mei Zhao, Gi Yoon Shin, Shaun Stice, …, Ron Gitaitis, Brian Kvitko, Bhabesh Dutta
- Mol Plant Microbe Interact, 10.1094/mpmi-08-22-0165-r
Genetic Methods and Construction of Chromosomal Mutations in Methanogenic Archaea
- Johanna Thomsen, Katrin Weidenbach, William W Metcalf, …, Katrin Weidenbach, William W Metcalf, Ruth A Schmitz
- Methods Mol Biol, 10.1007/978-1-0716-2445-6_6
Discovery, structure and mechanism of a tetraether lipid synthase
- Cody T Lloyd, David F Iwig, Bo Wang, …, William W Metcalf, Amie K Boal, Squire J Booker
- Nature, 10.1038/s41586-022-05120-2
Investigating Abiotic and Biotic Mechanisms of Pyrite Reduction
- Rachel L Spietz, Devon Payne, Gargi Kulkarni, William W Metcalf, Eric E Roden, Eric S Boyd
- None, 10.3389/fmicb.2022.878387
Role of internal loop dynamics in antibiotic permeability of outer membrane porins
- Archit Kumar Vasan, Nandan Haloi, Rebecca Joy Ulrich, …, Paul J Hergenrother, Diwakar Shukla, Emad Tajkhorshid
- Proc Natl Acad Sci U S A, 10.1073/pnas.2117009119
Rationalizing the generation of broad spectrum antibiotics with the addition of a positive charge
- Nandan Haloi, Archit Kumar Vasan, Emily J Geddes, …, William W Metcalf, Paul J Hergenrother, Emad Tajkhorshid
- None, 10.1039/d1sc04445a
A Phosphonate Natural Product Made by Pantoea ananatis is Necessary and Sufficient for the Hallmark Lesions of Onion Center Rot
- Alexander L A Polidore, Lucia Furiassi, Paul J Hergenrother, William W Metcalf
- mBio, 10.1128/mbio.03402-20
Genome Mining and Metabolomics Uncover a Rare d-Capreomycidine Containing Natural Product and Its Biosynthetic Gene Cluster
- James H Tryon, Jennifer C Rote, Li Chen, …, Kou-San Ju, Neil L Kelleher, Regan J Thomson
- ACS Chem Biol, 10.1021/acschembio.0c00663
Functional interactions between posttranslationally modified amino acids of methyl-coenzyme M reductase in Methanosarcina acetivorans
- Dipti D Nayak, Andi Liu, Neha Agrawal, …, Douglas A Mitchell, Satish K Nair, William W Metcalf
- PLoS Biol, 10.1371/journal.pbio.3000507
A computational framework to explore large-scale biosynthetic diversity
- Jorge C Navarro-Muñoz, Nelly Selem-Mojica, Michael W Mullowney, …, Neil L Kelleher, Francisco Barona-Gomez, Marnix H Medema
- Nat Chem Biol, 10.1038/s41589-019-0400-9
GDGT cyclization proteins identify the dominant archaeal sources of tetraether lipids in the ocean
- Zhirui Zeng, Xiao-Lei Liu, Kristen R Farley, …, William W Metcalf, Roger E Summons, Paula V Welander
- Proc Natl Acad Sci U S A, 10.1073/pnas.1909306116
Energy Conservation and Hydrogenase Function in Methanogenic Archaea, in Particular the Genus Methanosarcina
- Thomas D Mand, William W Metcalf
- Microbiol Mol Biol Rev, 10.1128/mmbr.00020-19
Fosmidomycin biosynthesis diverges from related phosphonate natural products
- Elizabeth I Parkinson, Annette Erb, Andrew C Eliot, Kou-San Ju, William W Metcalf
- Nat Chem Biol, 10.1038/s41589-019-0343-1