Delineation of proteome changes driven by cell size and growth rate
- Evgeny Zatulovskiy, Michael C Lanz, Shuyuan Zhang, Frank McCarthy, Joshua E Elias, Jan M Skotheim
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Increasing cell size remodels the proteome and promotes senescence
- Michael C Lanz, Evgeny Zatulovskiy, Matthew P Swaffer, …, Patrick McAlpine, Joshua E Elias, Jan M Skotheim
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RB depletion is required for the continuous growth of tumors initiated by loss of RB
- Alex Doan, Julia Arand, Diana Gong, …, Lukas E Dow, Jan M Skotheim, Julien Sage
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Liver homeostasis is maintained by midlobular zone 2 hepatocytes
- Yonglong Wei, Yunguan G Wang, Yuemeng Jia, …, Clifford J Rosen, Tao Wang, Hao Zhu
- Science, 10.1126/science.abb1625
Cell growth dilutes the cell cycle inhibitor Rb to trigger cell division
- Evgeny Zatulovskiy, Shuyuan Zhang, Daniel F Berenson, Benjamin R Topacio, Jan M Skotheim
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Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Hepatocellular Carcinomas Following Chronic Liver Injury
- Yu-Hsuan Lin, Shuyuan Zhang, Min Zhu, …, Adam Yopp, Tao Wang, Hao Zhu
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The origins and functions of hepatic polyploidy
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Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice Without Affecting Regeneration
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