Video highlight
Sex-specific metabolic adaptations in transgenic mice overexpressing cytochrome b 5 reductase-3
- Luz Marina Sánchez-Mendoza, Carlos Pérez-Sánchez, Sandra RodrÃguez-López, …, MarÃa I Burón, José A González-Reyes, José M Villalba
- Free Radic Biol Med, 10.1016/j.freeradbiomed.2023.07.012
Prolonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice
- Eleonora Duregon, Maria Emilia Fernandez, Jorge Martinez Romero, …, Miguel A Aon, Michel Bernier, Rafael de Cabo
- Cell Metab, 10.1016/j.cmet.2023.05.003
Drugs Targeting Mechanisms of Aging to Delay Age-Related Disease and Promote Healthspan: Proceedings of a National Institute on Aging Workshop
- Sara E Espinoza, Sundeep Khosla, Joseph A Baur, …, Joseph A Baur, Rafael de Cabo, Nicolas Musi
- J Gerontol A Biol Sci Med Sci, 10.1093/gerona/glad034
A hyper-quiescent chromatin state formed during aging is reversed by regeneration
- Na Yang, James R Occean, Daniël P Melters, …, Simone Sidoli, Yamini Dalal, Payel Sen
- Mol Cell, 10.1016/j.molcel.2023.04.005
Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging
- James R Occean, Na Yang, Yan Sun, …, Rafael deCabo, Simone Sidoli, Payel Sen
- None, 10.1101/2023.02.15.528714
Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network
- Sarinnapha M Vasunilashorn, Nadia Lunardi, John C Newman, …, Sharon K Inouye, Niccolò Terrando, Roderic G Eckenhoff
- Alzheimers Dement, 10.1002/alz.12941
A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan
- Nolan M Winicki, Alay P Nanavati, Christopher H Morrell, …, Steven J Sollott, Rafael de Cabo, Edward G Lakatta
- None, 10.3389/fcvm.2022.1096887
Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea in diabetes
- Hitoshi Watanabe, Wen Du, Jinsook Son, …, Yasutaka Miyachi, Rafael de Cabo, Domenico Accili
- Sci Transl Med, 10.1126/scitranslmed.abq4126
A remarkable adaptive paradigm of heart performance and protection emerges in response to marked cardiac-specific overexpression of ADCY8
- Kirill V Tarasov, Khalid Chakir, Daniel R Riordon, …, Loren Field, Steven J Sollott, Edward G Lakatta
- Elife, 10.7554/elife.80949
Redox state and the sirtuin deacetylases are major factors that regulate the acetylation status of the stress protein NQO1
- David Siegel, Peter S Harris, Cole R Michel, Rafael de Cabo, Kristofer S Fritz, David Ross
- None, 10.3389/fphar.2022.1015642
A specialized metabolic pathway partitions citrate in hydroxyapatite to impact mineralization of bones and teeth
- Naomi Dirckx, Qian Zhang, Emily Y Chu, …, Anne Le, Klaus Schmidt-Rohr, Thomas L Clemens
- Proc Natl Acad Sci U S A, 10.1073/pnas.2212178119
Emergence of heartbeat frailty in advanced age I: perspectives from life-long EKG recordings in adult mice
- Jack M Moen, Christopher H Morrell, Michael G Matt, …, Rafael de Cabo, Yael Yaniv, Edward G Lakatta
- Geroscience, 10.1007/s11357-022-00605-4
Serum Concentrations of Losartan Metabolites Correlate With Improved Physical Function in a Pilot Study of Prefrail Older Adults
- Jessica L Lee, Cissy Zhang, Reyhan Westbrook, …, Anne Le, Jeremy D Walston, Peter M Abadir
- J Gerontol A Biol Sci Med Sci, 10.1093/gerona/glac102
Resveratrol Blunts Mitochondrial Loss in Slow and Mixed Skeletal Muscle Phenotypes of Non-Human Primates following a Long-Term High Fat/Sugar Diet
- Jon-Philippe K Hyatt, Rafael de Cabo, Julie A Mattison, …, Jon-Philippe K Hyatt, Rafael de Cabo, Julie A Mattison
- J Diet Suppl, 10.1080/19390211.2022.2039340
