Academic lineage
- Frances H Arnold - Ph.D. student
MicroED Structure of a Protoglobin Reactive Carbene Intermediate
- Emma Danelius, Nicholas J Porter, Johan Unge, …, Johan Unge, Frances H Arnold, Tamir Gonen
- J Am Chem Soc, 10.1021/jacs.2c12004
Biocatalytic Carbene Transfer Using Diazirines
- Nicholas J Porter, Emma Danelius, Tamir Gonen, …, Emma Danelius, Tamir Gonen, Frances H Arnold
- J Am Chem Soc, 10.1021/jacs.2c02723
Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders
- Jeremy D Osko, Nicholas J Porter, Christophe Decroos, …, Ian D Krantz, Matthew A Deardorff, David W Christianson
- J Struct Biol, 10.1016/j.jsb.2020.107681
Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors
- Michael Morgen, Raphael R Steimbach, Magalie Géraldy, …, David W Christianson, Nikolas Gunkel, Aubry K Miller
- ChemMedChem, 10.1002/cmdc.202000149
Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6
- Jeremy D Osko, Nicholas J Porter, Poli Adi Narayana Reddy, …, Jacob M Hooker, Joseph M Salvino, David W Christianson
- J Med Chem, 10.1021/acs.jmedchem.9b01540
Preparation of a new construct of human histone deacetylase 8 for the crystallization of enzyme-inhibitor complexes
- Nicholas J Porter, David W Christianson
- Methods Enzymol, 10.1016/bs.mie.2019.06.029
Structure, mechanism, and inhibition of the zinc-dependent histone deacetylases
- Nicholas J Porter, David W Christianson
- Curr Opin Struct Biol, 10.1016/j.sbi.2019.01.004
Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors
- Katharina Vögerl, Nghia Ong, Johanna Senger, …, Wolfgang Sippl, Manfred Jung, Franz Bracher
- J Med Chem, 10.1021/acs.jmedchem.8b01090
Molecular Basis for the Selective Inhibition of Histone Deacetylase 6 by a Mercaptoacetamide Inhibitor
- Nicholas J Porter, Sida Shen, Cyril Barinka, Alan P Kozikowski, David W Christianson
- None, 10.1021/acsmedchemlett.8b00487
Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity
- Nicholas J Porter, Jeremy D Osko, Daniela Diedrich, …, Jacob M Hooker, Finn K Hansen, David W Christianson
- J Med Chem, 10.1021/acs.jmedchem.8b01013
Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6
- Nicholas J Porter, Florence F Wagner, David W Christianson
- Biochemistry, 10.1021/acs.biochem.8b00367
Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors
- Nicholas J Porter, Adaickapillai Mahendran, Ronald Breslow, David W Christianson
- Proc Natl Acad Sci U S A, 10.1073/pnas.1718823114
Persistent negative effects of alcohol drinking on aspects of novelty-directed behavior in male rhesus macaques
- Cassie M Chandler, Meagan E Follett, Nicholas J Porter, …, Gregory M Miller, James K Rowlett, Donna M Platt
- Alcohol, 10.1016/j.alcohol.2017.03.002
Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8
- Nicholas J Porter, David W Christianson
- ACS Chem Biol, 10.1021/acschembio.7b00330
Histone deacetylase 10 structure and molecular function as a polyamine deacetylase
- Yang Hai, Stephen A Shinsky, Nicholas J Porter, David W Christianson
- Nat Commun, 10.1038/ncomms15368