Fabrication of Microfluidic Devices for Continuously Monitoring Yeast Aging
- Richard O’Laughlin, Emerald Forrest, Jeff Hasty, …, Emerald Forrest, Jeff Hasty, Nan Hao
- None, 10.21769/bioprotoc.4782
Enhanced cellular longevity arising from environmental fluctuations
- Yuting Liu, Zhen Zhou, Songlin Wu, …, Lev S Tsimring, Jeff Hasty, Nan Hao
- None, 10.1101/2023.07.05.547867
A complex systems approach to aging biology
- Luigi Ferrucci, Tamà s Fülöp, Dominique Gravel, …, Andrew Rutenberg, Nicholas Stroustrup, Ravi Varadhan
- Nat Aging, 10.1038/s43587-022-00252-6
Quantitative cell imaging approaches to metastatic state profiling
- Andres J Nevarez, Nan Hao, Andres J Nevarez, Nan Hao
- None, 10.3389/fcell.2022.1048630
3D printing a biocompatible elastomer for modeling muscle regeneration after volumetric muscle loss
- Wisarut Kiratitanaporn, David B Berry, Anusorn Mudla, …, Nan Hao, Samuel R Ward, Shaochen Chen
- Biomater Adv, 10.1016/j.bioadv.2022.213171
Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with challenges to proteostasis
- Julie Paxman, Zhen Zhou, Richard O’Laughlin, …, Lorraine Pillus, Jeff Hasty, Nan Hao
- Elife, 10.7554/elife.75978
Advances in quantitative biology methods for studying replicative aging in Saccharomyces cerevisiae
- Richard O’Laughlin, Meng Jin, Yang Li, …, Lev S Tsimring, Jeff Hasty, Nan Hao
- None, 10.1016/j.tma.2019.09.002
Memorizing environmental signals through feedback and feedforward loops
- Yanfei Jiang, Nan Hao
- Curr Opin Cell Biol, 10.1016/j.ceb.2020.11.008
Cell-cycle-gated feedback control mediates desensitization to interferon stimulation
- Anusorn Mudla, Yanfei Jiang, Kei-Ichiro Arimoto, …, Matthew D Daugherty, Dong-Er Zhang, Nan Hao
- Elife, 10.7554/elife.58825
A programmable fate decision landscape underlies single-cell aging in yeast
- Yang Li, Yanfei Jiang, Julie Paxman, …, Lev S Tsimring, Jeff Hasty, Nan Hao
- Science, 10.1126/science.aax9552
Quantitative analysis of the yeast pheromone pathway
- James P Shellhammer, Amy E Pomeroy, Yang Li, …, Timothy C Elston, Nan Hao, Henrik G Dohlman
- Yeast, 10.1002/yea.3395
Divergent Aging of Isogenic Yeast Cells Revealed through Single-Cell Phenotypic Dynamics
- Meng Jin, Yang Li, Richard O’Laughlin, …, Lev S Tsimring, Jeff Hasty, Nan Hao
- Cell Syst, 10.1016/j.cels.2019.02.002
Flavin-based metabolic cycles are integral features of growth and division in single yeast cells
- Bridget L Baumgartner, Richard O’Laughlin, Meng Jin, Lev S Tsimring, Nan Hao, Jeff Hasty
- Sci Rep, 10.1038/s41598-018-35936-w
Mitogen-activated protein kinase (MAPK) dynamics determine cell fate in the yeast mating response
- Yang Li, Julie Roberts, Zohreh AkhavanAghdam, Nan Hao
- J Biol Chem, 10.1074/jbc.ac117.000548
Multigenerational silencing dynamics control cell aging
- Yang Li, Meng Jin, Richard O’Laughlin, …, Lorraine Pillus, Jeff Hasty, Nan Hao
- Proc Natl Acad Sci U S A, 10.1073/pnas.1703379114
Reconstructing the regulatory circuit of cell fate determination in yeast mating response
- Bin Shao, Haiyu Yuan, Rongfei Zhang, …, Qi Ouyang, Nan Hao, Chunxiong Luo
- PLoS Comput Biol, 10.1371/journal.pcbi.1005671
Coupled feedback loops control the stimulus-dependent dynamics of the yeast transcription factor Msn2
- Yanfei Jiang, Zohreh AkhavanAghdam, Lev S Tsimring, Nan Hao
- J Biol Chem, 10.1074/jbc.c117.800896
High-throughput single-cell analysis for the proteomic dynamics study of the yeast osmotic stress response
- Rongfei Zhang, Haiyu Yuan, Shujing Wang, …, Yong Chen, Nan Hao, Chunxiong Luo
- Sci Rep, 10.1038/srep42200
Dynamic control of gene regulatory logic by seemingly redundant transcription factors
- Zohreh AkhavanAghdam, Joydeb Sinha, Omar P Tabbaa, Nan Hao
- Elife, 10.7554/elife.18458
Protein expression patterns of the yeast mating response
- Haiyu Yuan, Rongfei Zhang, Bin Shao, …, Qi Ouyang, Nan Hao, Chunxiong Luo
- Integr Biol (Camb), 10.1039/c6ib00014b
High-throughput microfluidics to control and measure signaling dynamics in single yeast cells
- Anders S Hansen, Nan Hao, Erin K O’Shea, Anders S Hansen, Nan Hao, Erin K O’Shea
- Nat Protoc, 10.1038/nprot.2015.079
Tunable signal processing through modular control of transcription factor translocation
- Nan Hao, Bogdan A Budnik, Jeremy Gunawardena, Erin K O’Shea
- Science, 10.1126/science.1227299
Signal-dependent dynamics of transcription factor translocation controls gene expression
- Nan Hao, Erin K O’Shea
- Nat Struct Mol Biol, 10.1038/nsmb.2192
Control of MAPK specificity by feedback phosphorylation of shared adaptor protein Ste50
- Nan Hao, Yaxue Zeng, Timothy C Elston, Henrik G Dohlman
- J Biol Chem, 10.1074/jbc.c800179200
Dose-to-duration encoding and signaling beyond saturation in intracellular signaling networks
- Marcelo Behar, Nan Hao, Henrik G Dohlman, Timothy C Elston
- PLoS Comput Biol, 10.1371/journal.pcbi.1000197
Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5
- Nan Hao, Sujata Nayak, Marcelo Behar, …, Jeffrey Hasty, Timothy C Elston, Henrik G Dohlman
- Mol Cell, 10.1016/j.molcel.2008.04.016
Mathematical and computational analysis of adaptation via feedback inhibition in signal transduction pathways
- Marcelo Behar, Nan Hao, Henrik G Dohlman, Timothy C Elston
- Biophys J, 10.1529/biophysj.107.107516
Systems biology analysis of G protein and MAP kinase signaling in yeast
- N Hao, M Behar, T C Elston, H G Dohlman
- Oncogene, 10.1038/sj.onc.1210416
A systems-biology analysis of feedback inhibition in the Sho1 osmotic-stress-response pathway
- Nan Hao, Marcelo Behar, Stephen C Parnell, …, Christoph H Borchers, Timothy C Elston, Henrik G Dohlman
- Curr Biol, 10.1016/j.cub.2007.02.044
Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae
- Scott A Chasse, Paul Flanary, Stephen C Parnell, …, Jiyoung Y Cha, David P Siderovski, Henrik G Dohlman
- mSphere, 10.1128/ec.5.2.330-346.2006
Bistability, stochasticity, and oscillations in the mitogen-activated protein kinase cascade
- Xiao Wang, Nan Hao, Henrik G Dohlman, Timothy C Elston
- Biophys J, 10.1529/biophysj.105.073874