Optimization of nutrient utilization efficiency and productivity for algal cultures under light and dark cycles using genome-scale model process control
- Chien-Ting Li, Richard Eng, Cristal Zuniga, …, Yiqun Chen, Karsten Zengler, Michael J Betenbaugh
- NPJ Syst Biol Appl, 10.1038/s41540-022-00260-7
Cottonseed hydrolysate supplementation alters metabolic and proteomics responses in Chinese hamster ovary cell cultures
- Venkata Gayatri Dhara, Swetha Kumar, Lauren DeVine, …, Abbie J More, Eduardo Catchon Lau, Michael J Betenbaugh
- Biotechnol J, 10.1002/biot.202200243
Reconstruction of reverse transsulfuration pathway enables cysteine biosynthesis and enhances resilience to oxidative stress in Chinese Hamster Ovary cells
- Yiqun Chen, Michael J Betenbaugh, Yiqun Chen, …, Michael J Betenbaugh, Yiqun Chen, Michael J Betenbaugh
- Metab Eng, 10.1016/j.ymben.2023.02.010
Methodological approaches to optimize multiplex oral fluid SARS-CoV-2 IgG assay performance and correlation with serologic and neutralizing antibody responses
- Nora Pisanic, Annukka A R Antar, Kate L Kruczynski, …, David L Thomas, Yukari C Manabe, Christopher D Heaney
- J Immunol Methods, 10.1016/j.jim.2023.113440
CHOGlycoNET: Comprehensive glycosylation reaction network for CHO cells
- Pavlos Kotidis, Roberto Donini, Johnny Arnsdorf, …, Nathan E Lewis, Frederick Krambeck, Cleo Kontoravdi
- Metab Eng, 10.1016/j.ymben.2022.12.009
Generation of reference cell lines, media, and a process platform for CHO cell biomanufacturing
- Lauren T Cordova, Hussain Dahodwala, Kathryn S Elliott, …, Michael P Gillmeister, Sarah W Harcum, Kelvin H Lee
- Biotechnol Bioeng, 10.1002/bit.28290
Comprehensive N- and O-Glycoproteomic Analysis of Multiple Chinese Hamster Ovary Host Cell Lines
- Qiong Wang, Tiexin Wang, Wells W Wu, …, Rong-Fong Shen, Michael J Betenbaugh, John F Cipollo
- J Proteome Res, 10.1021/acs.jproteome.2c00207
A proteomics approach to decipher a sticky CHO situation
- Swetha Kumar, Amit Kumar, Steven Huhn, …, Robert Cole, Zhimei Du, Michael Betenbaugh
- Biotechnol Bioeng, 10.1002/bit.28108
Attenuation of glutamine synthetase selection marker improves product titer and reduces glutamine overflow in Chinese hamster ovary cells
- Sarah A Sacco, Angela M Tuckowski, Irina Trenary, …, Michael J Betenbaugh, Jamey D Young, Kevin D Smith
- Biotechnol Bioeng, 10.1002/bit.28084