SARS-CoV-2 protein ORF8 limits expression levels of Spike antigen and facilitates immune evasion of infected host cells
- Ik-Jung Kim, Yong-Ho Lee, Mir M Khalid, …, Yini Zhang, Melanie Ott, Eric Verdin
- J Biol Chem, 10.1016/j.jbc.2023.104955
Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication
- Eddie Wehri, Rahul K Suryawanshi, Elizabeth King, …, Melanie Ott, Julia Schaletzky, Niren Murthy
- None, 10.1039/d3ra01915b
Structure-Based Discovery of Inhibitors of the SARS-CoV-2 Nsp14 N7-Methyltransferase
- Isha Singh, Fengling Li, Elissa A Fink, …, John J Irwin, Masoud Vedadi, Brian K Shoichet
- J Med Chem, 10.1021/acs.jmedchem.2c02120
A covalent inhibitor targeting the papain-like protease from SARS-CoV-2 inhibits viral replication
- Albert Vallejo Gracia, Lydia Boike, Kristoffer Leon, …, G Renuka Kumar, Melanie Ott, Niren Murthy
- None, 10.1039/d3ra00426k
The lysine methyltransferase SMYD5 amplifies HIV-1 transcription and is post-transcriptionally upregulated by Tat and USP11
- Daniela Boehm, Victor Lam, Martina Schnolzer, …, Victor Lam, Martina Schnolzer, Melanie Ott
- Cell Rep, 10.1016/j.celrep.2023.112234
SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants
- Lisiena Hysenaj, Samantha Little, Kayla Kulhanek, …, Melanie Ott, Johannes R Kratz, Jeroen P Roose
- Stem Cell Reports, 10.1016/j.stemcr.2023.01.011
Nuclear accumulation of host transcripts during Zika Virus Infection
- Kristoffer E Leon, Mir M Khalid, Ryan A Flynn, …, Carolyn Bertozzi, Jan E Carette, Melanie Ott
- PLoS Pathog, 10.1371/journal.ppat.1011070
Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons
- Weili Kong, Mauricio Montano, Michael J Corley, …, Melanie Ott, Lishomwa C Ndhlovu, Warner C Greene
- mBio, 10.1128/mbio.02308-22
Viral Hijacking of BET Proteins
- Irene P Chen, Melanie Ott, Irene P Chen, Melanie Ott
- Viruses, 10.3390/v14102274
Neutralizing Immunity Induced Against the Omicron BA.1 and BA.2 Variants in Vaccine Breakthrough Infections
- Noah Brazer, Mary Kate Morris, Venice Servellita, …, J Daniel Kelly, Carl Hanson, Charles Y Chiu
- J Infect Dis, 10.1093/infdis/jiac384
