Phosphoinositide acyl chain saturation drives CD8 + effector T cell signaling and function
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- Nat Immunol, 10.1038/s41590-023-01419-y
Metabolites: fuelling the immune response
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Targeting memory T cell metabolism to improve immunity
- Mauro Corrado, Erika L Pearce
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Research Techniques Made Simple: Profiling Cellular Energy Metabolism
- Mario Fabri, Matteo Villa, Michal A Stanczak, Joy Edwards-Hicks, Mauro Corrado, Erika L Pearce
- J Invest Dermatol, 10.1016/j.jid.2021.09.004
Opa1 relies on cristae preservation and ATP synthase to curtail reactive oxygen species accumulation in mitochondria
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- Redox Biol, 10.1016/j.redox.2021.101944
Deletion of the mitochondria-shaping protein Opa1 during early thymocyte maturation impacts mature memory T cell metabolism
- Mauro Corrado, Dijana Samardžić, Marta Giacomello, …, Nisha Rana, Erika L Pearce, Luca Scorrano
- Cell Death Differ, 10.1038/s41418-021-00747-6
Dynamic Cardiolipin Synthesis Is Required for CD8 + T Cell Immunity
- Mauro Corrado, Joy Edwards-Hicks, Matteo Villa, …, David O’Sullivan, Edward J Pearce, Erika L Pearce
- Cell Metab, 10.1016/j.cmet.2020.11.003
Triacylglycerol synthesis enhances macrophage inflammatory function
- Angela Castoldi, Lauar B Monteiro, Nikki van Teijlingen Bakker, …, Joy Edwards-Hicks, Erika L Pearce, Edward J Pearce
- Nat Commun, 10.1038/s41467-020-17881-3
JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction
- Luca Simula, Mauro Corrado, Benedetta Accordi, …, Franco Locatelli, Francesco Cecconi, Silvia Campello
- Cell Death Differ, 10.1038/s41418-020-0540-1
Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function
- Cameron S Field, Francesc Baixauli, Ryan L Kyle, …, Edward J Pearce, Bruce R Blazar, Erika L Pearce
- Cell Metab, 10.1016/j.cmet.2019.11.021
Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation
- Daniel J Puleston, Michael D Buck, Ramon I Klein Geltink, …, Edward J Pearce, Stefan Balabanov, Erika L Pearce
- Cell Metab, 10.1016/j.cmet.2019.05.003
Acetate Promotes T Cell Effector Function during Glucose Restriction
- Jing Qiu, Matteo Villa, David E Sanin, …, Thomas Jenuwein, Edward J Pearce, Erika L Pearce
- Cell Rep, 10.1016/j.celrep.2019.04.022
Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2
- David E Sanin, Mai Matsushita, Ramon I Klein Geltink, …, Stanley Ching-Cheng Huang, Erika L Pearce, Edward J Pearce
- Immunity, 10.1016/j.immuni.2018.10.011