A system that delivers an antioxidant to mitochondria for the treatment of drug-induced liver injury
- Mitsue Hibino, Masatoshi Maeki, Manabu Tokeshi, …, Yoichi Ishitsuka, Hideyoshi Harashima, Yuma Yamada
- Sci Rep, 10.1038/s41598-023-33893-7
Controlling lamellarity and physicochemical properties of liposomes prepared using a microfluidic device
- Yuka Matsuura-Sawada, Shuya Uno, Koichi Wada, …, Shuya Uno, Koichi Wada, Manabu Tokeshi
- Biomater Sci, 10.1039/d2bm01703b
Effect of Organic Solvents on a Production of PLGA-Based Drug-Loaded Nanoparticles Using a Microfluidic Device
- Yi Bao, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Manabu Tokeshi
- None, 10.1021/acsomega.2c03137
PEGylation of silver nanoparticles by physisorption of cyclic poly(ethylene glycol) for enhanced dispersion stability, antimicrobial activity, and cytotoxicity
- Onyinyechukwu Justina Oziri, Yubo Wang, Tomohisa Watanabe, …, Shin-Ichiro Sato, Yutaka Miura, Takuya Yamamoto
- None, 10.1039/d1na00720c
Preparation of size-tunable sub-200 nm PLGA-based nanoparticles with a wide size range using a microfluidic platform
- Yi Bao, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Manabu Tokeshi
- PLoS One, 10.1371/journal.pone.0271050
On the size-regulation of RNA-loaded lipid nanoparticles synthesized by microfluidic device
- Kento Okuda, Yusuke Sato, Kazuki Iwakawa, …, Masatoshi Maeki, Manabu Tokeshi, Hideyoshi Harashima
- J Control Release, 10.1016/j.jconrel.2022.06.017
Non-competitive fluorescence polarization immunosensing for CD9 detection using a peptide as a tracer
- Kazuki Takahashi, Shunsuke Chida, Thanawat Suwatthanarak, …, Akihide Hibara, Mina Okochi, Manabu Tokeshi
- Lab Chip, 10.1039/d2lc00224h
Three-dimensional, symmetrically assembled microfluidic device for lipid nanoparticle production
- Niko Kimura, Masatoshi Maeki, Kosuke Sasaki, …, Hirofumi Tani, Hideyoshi Harashima, Manabu Tokeshi
- None, 10.1039/d0ra08826a
Production of siRNA-Loaded Lipid Nanoparticles using a Microfluidic Device
- Masatoshi Maeki, Yuto Okada, Shuya Uno, …, Akihiko Ishida, Hirofumi Tani, Manabu Tokeshi
- J Vis Exp, 10.3791/62999
Enzyme kinetics in confined geometries at the single enzyme level
- Hisashi Murahara, Noritada Kaji, Manabu Tokeshi, Yoshinobu Baba
- Analyst, 10.1039/d1an02024b
Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery
- Masatoshi Maeki, Shuya Uno, Ayuka Niwa, Yuto Okada, Manabu Tokeshi
- J Control Release, 10.1016/j.jconrel.2022.02.017
One-Step Production Using a Microfluidic Device of Highly Biocompatible Size-Controlled Noncationic Exosome-like Nanoparticles for RNA Delivery
- Niko Kimura, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Manabu Tokeshi
- ACS Appl Bio Mater, 10.1021/acsabm.0c01519
Paper-Based Analytical Device for the On-Site Detection of Nerve Agents
- Akinori Yamaguchi, Hajime Miyaguchi, Akihiko Ishida, Manabu Tokeshi
- ACS Appl Bio Mater, 10.1021/acsabm.1c00655
Topology-Dependent Interaction of Cyclic Poly(ethylene glycol) Complexed with Gold Nanoparticles against Bovine Serum Albumin for a Colorimetric Change
- Onyinyechukwu Justina Oziri, Masatoshi Maeki, Manabu Tokeshi, …, Toshifumi Satoh, Shin-Ichiro Sato, Takuya Yamamoto
- Langmuir, 10.1021/acs.langmuir.1c03027
Electrochemical enzyme-based blood ATP and lactate sensor for a rapid and straightforward evaluation of illness severity
- Keine Nishiyama, Ryohei Mizukami, Shizuka Kuki, …, Masatoshi Maeki, Hirofumi Tani, Manabu Tokeshi
- Biosens Bioelectron, 10.1016/j.bios.2021.113832
Microchip Immunoassays for Monitoring Renal Function: Rapid, Low-Cost, and Highly Sensitive Quantification of Urinary Biomarkers of Diabetic Nephropathy
- Toshihiro Kasama, Miaomiao Sun, Noritada Kaji, …, Manabu Tokeshi, Seiichi Matsuo, Yoshinobu Baba
- None, 10.3390/mi12111353
Determination of blood lithium-ion concentration using digital microfluidic whole-blood separation and preloaded paper sensors
- Takeshi Komatsu, Manabu Tokeshi, Shih-Kang Fan
- Biosens Bioelectron, 10.1016/j.bios.2021.113631
Advances in Multiplexed Paper-Based Analytical Devices for Cancer Diagnosis: A Review of Technological Developments
- Nihan Yonet-Tanyeri, Benjamin Z Ahlmark, Steven R Little
- None, 10.1002/admt.202001138
Facile and rapid detection of SARS-CoV-2 antibody based on a noncompetitive fluorescence polarization immunoassay in human serum samples
- Keine Nishiyama, Kazuki Takahashi, Mao Fukuyama, …, Koji Shigemura, Akihide Hibara, Manabu Tokeshi
- Biosens Bioelectron, 10.1016/j.bios.2021.113414
Delivery of Oligonucleotides Using a Self-Degradable Lipid-Like Material
- Hiroki Tanaka, Nae Takata, Yu Sakurai, …, Masatoshi Maeki, Manabu Tokeshi, Hidetaka Akita
- None, 10.3390/pharmaceutics13040544
Simple Approach for Fluorescence Signal Amplification Utilizing a Poly(vinyl alcohol)-Based Polymer Structure in a Microchannel
- Keine Nishiyama, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Hideaki Hisamoto, Manabu Tokeshi
- None, 10.1021/acsomega.1c00057
Dip-Type Paper-Based Analytical Device for Straightforward Quantitative Detection without Precise Sample Introduction
- Takeshi Komatsu, Ryoga Maeda, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Manabu Tokeshi
- ACS Sens, 10.1021/acssensors.0c02367
Non-competitive fluorescence polarization immunoassay for detection of H5 avian influenza virus using a portable analyzer
- Keine Nishiyama, Yohei Takeda, Kazuki Takahashi, …, Akihide Hibara, Haruko Ogawa, Manabu Tokeshi
- Anal Bioanal Chem, 10.1007/s00216-021-03193-y
Rapid, sensitive universal paper-based device enhances competitive immunoassays of small molecules
- Takeshi Komatsu, Yuki Sato, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Manabu Tokeshi
- Anal Chim Acta, 10.1016/j.aca.2020.12.003
Development of an immuno-wall device for the rapid and sensitive detection of EGFR mutations in tumor tissues resected from lung cancer patients
- Naoyuki Yogo, Tetsunari Hase, Toshihiro Kasama, …, Manabu Tokeshi, Yoshinobu Baba, Yoshinori Hasegawa
- PLoS One, 10.1371/journal.pone.0241422
Noncompetitive Fluorescence Polarization Immunoassay for Protein Determination
- Mao Fukuyama, Ayano Nakamura, Keine Nishiyama, …, Manabu Tokeshi, Koji Shigemura, Akihide Hibara
- Anal Chem, 10.1021/acs.analchem.0c02300
The use of design of experiments with multiple responses to determine optimal formulations for in vivo hepatic mRNA delivery
- Akari Hashiba, Manaya Toyooka, Yusuke Sato, Masatoshi Maeki, Manabu Tokeshi, Hideyoshi Harashima
- J Control Release, 10.1016/j.jconrel.2020.08.031
Real-Time Measurement of Protein Crystal Growth Rates within the Microfluidic Device to Understand the Microspace Effect
- Masatoshi Maeki, Shohei Yamazaki, Reo Takeda, Akihiko Ishida, Hirofumi Tani, Manabu Tokeshi
- None, 10.1021/acsomega.0c01285
Development of a Microfluidic-Based Post-Treatment Process for Size-Controlled Lipid Nanoparticles and Application to siRNA Delivery
- Niko Kimura, Masatoshi Maeki, Yusuke Sato, …, Hirofumi Tani, Hideyoshi Harashima, Manabu Tokeshi
- ACS Appl Mater Interfaces, 10.1021/acsami.0c05489
Observation of Ethanol-Induced Condensation and Decondensation Processes at a Single-DNA Molecular Level in Microfluidic Devices Equipped with a Rapid Solution Exchange System
- Hiroshi Suzuki, Kentaro Fujiyoshi, Noritada Kaji, Manabu Tokeshi, Yoshinobu Baba
- Anal Chem, 10.1021/acs.analchem.0c01417
Rapid detection of anti-H5 avian influenza virus antibody by fluorescence polarization immunoassay using a portable fluorescence polarization analyzer
- Keine Nishiyama, Yohei Takeda, Masatoshi Maeki, …, Kunitoshi Imai, Haruko Ogawa, Manabu Tokeshi
- None, 10.1016/j.snb.2020.128160
Paper-Based Device for the Facile Colorimetric Determination of Lithium Ions in Human Whole Blood
- Takeshi Komatsu, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Manabu Tokeshi
- ACS Sens, 10.1021/acssensors.9b02218
The Effect of Size and Charge of Lipid Nanoparticles Prepared by Microfluidic Mixing on Their Lymph Node Transitivity and Distribution
- Takashi Nakamura, Minori Kawai, Yusuke Sato, Masatoshi Maeki, Manabu Tokeshi, Hideyoshi Harashima
- Mol Pharm, 10.1021/acs.molpharmaceut.9b01182
Rapid, Sensitive, and Selective Detection of H5 Hemagglutinin from Avian Influenza Virus Using an Immunowall Device
- Kenia ChĆ”vez Ramos, Keine Nishiyama, Masatoshi Maeki, …, Toshihiro Kasama, Yoshinobu Baba, Manabu Tokeshi
- None, 10.1021/acsomega.9b02788
Development of the iLiNP Device: Fine Tuning the Lipid Nanoparticle Size within 10 nm for Drug Delivery
- Niko Kimura, Masatoshi Maeki, Yusuke Sato, …, Hirofumi Tani, Hideyoshi Harashima, Manabu Tokeshi
- None, 10.1021/acsomega.8b00341
A paper-based analytical device coupled with electrochemical detection for the determination of dexamethasone and prednisoloneĀ in adulterated traditional medicines
- Vitsarut Primpray, Orawon Chailapakul, Manabu Tokeshi, Theerasak Rojanarata, Wanida Laiwattanapaisal
- Anal Chim Acta, 10.1016/j.aca.2019.05.072
An Electrochemical Sensor Based on Structure Switching of Dithiol-modified Aptamer for Simple Detection of Ochratoxin A
- Donny Nugraha Mazaafrianto, Akihiko Ishida, Masatoshi Maeki, Hirofumi Tani, Manabu Tokeshi
- Anal Sci, 10.2116/analsci.19p240
High-throughput fluorescence polarization immunoassay by using a portable fluorescence polarization imaging analyzer
- Osamu Wakao, Ken Satou, Ayano Nakamura, …, Koji Shigemura, Akihide Hibara, Manabu Tokeshi
- Lab Chip, 10.1039/c9lc00256a
Ultrasensitive detection of disease biomarkers using an immuno-wall device with enzymatic amplification
- Keine Nishiyama, Toshihiro Kasama, Seiya Nakamata, …, Hirofumi Tani, Yoshinobu Baba, Manabu Tokeshi
- Analyst, 10.1039/c9an00480g
The Use of a Microfluidic Device to Encapsulate a Poorly Water-Soluble Drug CoQ 10 in Lipid Nanoparticles and an Attempt to Regulate Intracellular Trafficking to Reach Mitochondria
- Mitsue Hibino, Yuma Yamada, Naoki Fujishita, …, Masatoshi Maeki, Manabu Tokeshi, Hideyoshi Harashima
- J Pharm Sci, 10.1016/j.xphs.2019.04.001
Development of a microdevice for facile analysis of theophylline in whole blood by a cloned enzyme donor immunoassay
- Keine Nishiyama, Kanako Sugiura, Noritada Kaji, Manabu Tokeshi, Yoshinobu Baba
- Lab Chip, 10.1039/c8lc01105b
Recent Microdevice-Based Aptamer Sensors
- Donny Nugraha Mazaafrianto, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Manabu Tokeshi
- None, 10.3390/mi9050202