Extreme Sensitivity of Fitness to Environmental Conditions: Lessons from #1BigBatch
- Grant Kinsler, Kara Schmidlin, Daphne Newell, …, Grace Lam, Dmitri Petrov, Kerry Geiler-Samerotte
- J Mol Evol, 10.1007/s00239-023-10114-3
Best Practices in Microbial Experimental Evolution
- Gregory I Lang, Gregory I Lang, Gregory I Lang, Gregory I Lang, Kerry Geiler-Samerotte, Gregory I Lang
- J Mol Evol, 10.1007/s00239-023-10119-y
Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes
- Leandra Brettner, Wei-Chin Ho, Kara Schmidlin, …, Sam Apodaca, Rachel Eder, Kerry Geiler-Samerotte
- Curr Opin Genet Dev, 10.1016/j.gde.2022.101951
Constructive Neutral Evolution 20 Years Later
- Sergio A Muñoz-Gómez, Gaurav Bilolikar, Jeremy G Wideman, Kerry Geiler-Samerotte
- J Mol Evol, 10.1007/s00239-021-09996-y
Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation
- Grant Kinsler, Kerry Geiler-Samerotte, Dmitri A Petrov
- Elife, 10.7554/elife.61271
Extent and context dependence of pleiotropy revealed by high-throughput single-cell phenotyping
- Kerry A Geiler-Samerotte, Shuang Li, Charalampos Lazaris, …, Chelsea Ramjeawan, Annalise B Paaby, Mark L Siegal
- PLoS Biol, 10.1371/journal.pbio.3000836
Emerging Frontiers in the Study of Molecular Evolution
- David A Liberles, Belinda Chang, Kerry Geiler-Samerotte, …, William Murphy, David Posada, Andrew Storfer
- J Mol Evol, 10.1007/s00239-020-09932-6
Why and how to study genetic changes with context-dependent effects
- Yuichi Eguchi, Gaurav Bilolikar, Kerry Geiler-Samerotte
- Curr Opin Genet Dev, 10.1016/j.gde.2019.08.003
Decanalizing thinking on genetic canalization
- Kerry Geiler-Samerotte, Federica M O Sartori, Mark L Siegal
- Semin Cell Dev Biol, 10.1016/j.semcdb.2018.05.008
Selection Transforms the Landscape of Genetic Variation Interacting with Hsp90
- Kerry A Geiler-Samerotte, Yuan O Zhu, Benjamin E Goulet, David W Hall, Mark L Siegal
- PLoS Biol, 10.1371/journal.pbio.2000465
Development of a Comprehensive Genotype-to-Fitness Map of Adaptation-Driving Mutations in Yeast
- Sandeep Venkataram, Barbara Dunn, Yuping Li, …, Daniel S Fisher, Gavin Sherlock, Dmitri A Petrov
- Cell, 10.1016/j.cell.2016.08.002
Quantifying condition-dependent intracellular protein levels enables high-precision fitness estimates
- Kerry A Geiler-Samerotte, Tatsunori Hashimoto, Michael F Dion, Bogdan A Budnik, Edoardo M Airoldi, D Allan Drummond
- PLoS One, 10.1371/journal.pone.0075320
The details in the distributions: why and how to study phenotypic variability
- K A Geiler-Samerotte, C R Bauer, S Li, N Ziv, D Gresham, M L Siegal
- Curr Opin Biotechnol, 10.1016/j.copbio.2013.03.010
Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects
- Faith Pangilinan, Anne M Molloy, James L Mills, …, Barry Shane, John M Scott, Lawrence C Brody
- BMC Med Genomics, 10.1186/1471-2350-13-62
Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast
- Kerry A Geiler-Samerotte, Michael F Dion, Bogdan A Budnik, Stephanie M Wang, Daniel L Hartl, D Allan Drummond
- Proc Natl Acad Sci U S A, 10.1073/pnas.1017570108