Scholar: Karthikeyani Chellappa

Karthikeyani Chellappa

Academic lineage

NAD + precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury

  • Tomohito Doke, Sarmistha Mukherjee, Dhanunjay Mukhi, …, Beishan Chen, Joseph A Baur, Katalin Susztak
  • Nat Metab, 10.1038/s42255-023-00761-7
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NAD precursors cycle between host tissues and the gut microbiome

  • Karthikeyani Chellappa, Melanie R McReynolds, Wenyun Lu, …, Marie E Migaud, Joshua D Rabinowitz, Joseph A Baur
  • Cell Metab, 10.1016/j.cmet.2022.11.004
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NAD + flux is maintained in aged mice despite lower tissue concentrations

  • Melanie R McReynolds, Karthikeyani Chellappa, Eric Chiles, …, Xiaoyang Su, Joshua D Rabinowitz, Joseph A Baur
  • Cell Syst, 10.1016/j.cels.2021.09.001
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SIRT3 is required for liver regeneration but not for the beneficial effect of nicotinamide riboside

  • Sarmistha Mukherjee, James Mo, Lauren M Paolella, …, Qiang Tong, Karthikeyani Chellappa, Joseph A Baur
  • JCI Insight, 10.1172/jci.insight.147193
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CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD + and NMN levels

  • Claudia C S Chini, Thais R Peclat, Gina M Warner, …, Joshua D Rabinowitz, Joseph A Baur, Eduardo N Chini
  • Nat Metab, 10.1038/s42255-020-00298-z
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Rapamycin maintains NAD + /NADH redox homeostasis in muscle cells

  • Zhigang Zhang, He N Xu, Siyu Li, …, Huaqing Zhao, Lin Z Li, Joseph A Baur
  • Aging (Albany NY), 10.18632/aging.103954
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mTORC1 restrains adipocyte lipolysis to prevent systemic hyperlipidemia

  • Lauren M Paolella, Sarmistha Mukherjee, Cassie M Tran, …, Wenyun Lu, Karthikeyani Chellappa, Joseph A Baur
  • Mol Metab, 10.1016/j.molmet.2019.12.003
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Hypothalamic mTORC2 is essential for metabolic health and longevity

  • Karthikeyani Chellappa, Jacqueline A Brinkman, Sarmistha Mukherjee, …, Georgios K Paschos, Joseph A Baur, Dudley W Lamming
  • Aging Cell, 10.1111/acel.13014
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Optical Redox Imaging of Fixed Unstained Muscle Slides Reveals Useful Biological Information

  • He N Xu, Huaqing Zhao, Karthikeyani Chellappa, …, Shoko Nioka, Joseph A Baur, Lin Z Li
  • Mol Imaging Biol, 10.1007/s11307-019-01348-z
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Nicotinamide adenine dinucleotide is transported into mammalian mitochondria

  • Antonio Davila, Ling Liu, Karthikeyani Chellappa, …, Marie E Migaud, Joshua D Rabinowitz, Joseph A Baur
  • Elife, 10.7554/elife.33246
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Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

  • Ling Liu, Xiaoyang Su, William J Quinn, …, Timothy J Mitchison, Joseph A Baur, Joshua D Rabinowitz
  • Cell Metab, 10.1016/j.cmet.2018.03.018
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Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration

  • Sarmistha Mukherjee, Karthikeyani Chellappa, Andrea Moffitt, …, James G Davis, Beamon Agarwal, Joseph A Baur
  • Hepatology, 10.1002/hep.28912
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Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle

  • David W Frederick, Emanuele Loro, Ling Liu, …, Joshua D Rabinowitz, Tejvir S Khurana, Joseph A Baur
  • Cell Metab, 10.1016/j.cmet.2016.07.005
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