USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy
- Diana Campos-Iglesias, Julia M Fraile, Gabriel Bretones, …, Jesús Vázquez, Carlos López-Otín, José M P Freije
- Cell Death Dis, 10.1038/s41419-023-05600-x
Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice
- Clea Bárcena, Rafael Valdés-Mas, Pablo Mayoral, …, José M P Freije, Pedro M Quirós, Carlos López-Otín
- Nat Med, 10.1038/s41591-019-0504-5
Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism
- Clea Bárcena, Pedro M Quirós, Sylvère Durand, …, Guido Kroemer, José M P Freije, Carlos López-Otín
- Cell Rep, 10.1016/j.celrep.2018.07.089
Loss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causes preimplantation lethality in mice
- Julia M Fraile, Diana Campos-Iglesias, Francisco Rodríguez, …, José I Martín-Subero, José M P Freije, Carlos López-Otín
- J Biol Chem, 10.1074/jbc.m117.788430
Deubiquitination in cancer stem cells
- Julia M Fraile, Diana Campos-Iglesias, José M P Freije
- Aging (Albany NY), 10.18632/aging.101182
USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer
- Julia M Fraile, Eusebio Manchado, Amaia Lujambio, …, Scott W Lowe, Carlos López-Otín, José M P Freije
- J Biol Chem, 10.1074/jbc.m116.762757