Academic lineage
Methionine synthase supports tumour tetrahydrofolate pools
- Jonathan M Ghergurovich, Xincheng Xu, Joshua Z Wang, …, Rolf-Peter Ryseck, Lin Wang, Joshua D Rabinowitz
- Nat Metab, 10.1038/s42255-021-00465-w
Local production of lactate, ribose phosphate, and amino acids within human triple-negative breast cancer
- Jonathan M Ghergurovich, Jessica D Lang, Maren K Levin, …, Daniel D Von Hoff, Joyce O’Shaughnessy, Joshua D Rabinowitz
- Med, 10.1016/j.medj.2021.03.009
Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation
- Yang Zhang, Yi Xu, Wenyun Lu, …, Ian A Blair, Joshua D Rabinowitz, Xiaolu Yang
- Cell Metab, 10.1016/j.cmet.2020.10.002
A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway
- Jonathan M Ghergurovich, Juan C García-Cañaveras, Joshua Wang, …, Ulf H Beier, Hahn Kim, Joshua D Rabinowitz
- Nat Chem Biol, 10.1038/s41589-020-0533-x
SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia
- Juan C García-Cañaveras, Olga Lancho, Gregory S Ducker, …, Hahn Kim, Daniel Herranz, Joshua D Rabinowitz
- Leukemia, 10.1038/s41375-020-0845-6
T Cell Activation Depends on Extracellular Alanine
- Noga Ron-Harel, Jonathan M Ghergurovich, Giulia Notarangelo, …, Arlene H Sharpe, Joshua D Rabinowitz, Marcia C Haigis
- Cell Rep, 10.1016/j.celrep.2019.08.034
As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid
- Natalya N Pavlova, Sheng Hui, Jonathan M Ghergurovich, …, Joshua D Rabinowitz, Craig B Thompson, Ji Zhang
- Cell Metab, 10.1016/j.cmet.2017.12.006