SOX9 drives KRAS-induced lung adenocarcinoma progression and suppresses anti-tumor immunity
- Hua Zhong, Wen Lu, Yong Tang, …, Shridar Ganesan, Hatim E Sabaawy, Sharon R Pine
- Oncogene, 10.1038/s41388-023-02715-5
Slow TCA flux and ATP production in primary solid tumours but not metastases
- Caroline R Bartman, Daniel R Weilandt, Yihui Shen, …, Jessie Yanxiang Guo, Yibin Kang, Joshua D Rabinowitz
- Nature, 10.1038/s41586-022-05661-6
Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors
- Vrushank Bhatt, Taijin Lan, Wenping Wang, …, Sharon R Pine, Eileen White, Jessie Yanxiang Guo
- Cell Death Dis, 10.1038/s41419-023-05592-8
Transient systemic autophagy ablation irreversibly inhibits lung tumor cell metabolism and promotes T-cell mediated tumor killing
- Kyle Nunn, Jessie Yanxiang Guo, Kyle Nunn, …, Jessie Yanxiang Guo, Kyle Nunn, Jessie Yanxiang Guo
- Autophagy, 10.1080/15548627.2022.2141534
Transient Systemic Autophagy Inhibition Is Selectively and Irreversibly Deleterious to Lung Cancer
- Khoosheh Khayati, Vrushank Bhatt, Taijin Lan, …, Ping Xie, Eileen White, Jessie Yanxiang Guo
- Cancer Res, 10.1158/0008-5472.can-22-1039
Ym155 localizes to the mitochondria leading to mitochondria dysfunction and activation of AMPK that inhibits BMP signaling in lung cancer cells
- Arindam Mondal, Dongxuan Jia, Vrushank Bhatt, …, Jacques Roberge, Jessie Yanxiang Guo, John Langenfeld
- Sci Rep, 10.1038/s41598-022-17446-y
Clinical outcomes and immune phenotypes associated with STK11 co-occurring mutations in non-small cell lung cancer
- Jyoti Malhotra, Brid Ryan, Malini Patel, …, Joseph Aisner, Salma K Jabbour, Sharon Pine
- None, 10.21037/jtd-21-1377
Leukemia inhibitory factor drives glucose metabolic reprogramming to promote breast tumorigenesis
- Xuetian Yue, Jianming Wang, Chun-Yuan Chang, …, Lanjing Zhang, Zhaohui Feng, Wenwei Hu
- Cell Death Dis, 10.1038/s41419-022-04820-x
Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth
- Lifeng Yang, Tara TeSlaa, Serina Ng, …, Jessie Yanxiang Guo, Haiyong Han, Joshua D Rabinowitz
- Med, 10.1016/j.medj.2021.12.008
Tumor suppressor PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7/autophagy to suppress neurodegeneration
- Yanying Huo, Akshada Sawant, Yongmei Tan, …, M Maral Mouradian, Eileen White, Bing Xia
- PLoS Genet, 10.1371/journal.pgen.1010138
Targeting hepatic kisspeptin receptor ameliorates nonalcoholic fatty liver disease in a mouse model
- Stephania Guzman, Magdalena Dragan, Hyokjoon Kwon, …, Fredric E Wondisford, Andy V Babwah, Moshmi Bhattacharya
- J Clin Invest, 10.1172/jci145889
Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes
- Yingying Liu, Samantha Gokhale, Jaeyong Jung, …, Wei-Xing Zong, Eileen White, Ping Xie
- Front Immunol, 10.3389/fimmu.2021.670338
Autophagy and tumorigenesis
- Michael Rangel, Jerry Kong, Vrushank Bhatt, …, Vrushank Bhatt, Khoosheh Khayati, Jessie Yanxiang Guo
- FEBS J, 10.1111/febs.16125