Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis
- Joe Nassour, Lucia Gutierrez Aguiar, Adriana Correia, …, Vinay Tergaonkar, Gerald S Shadel, Jan Karlseder
- Nature, 10.1038/s41586-023-05710-8
DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages
- Isidoro Cobo, Tiffany N Tanaka, Kailash Chandra Mangalhara, …, Menno de Winther, Gerald S Shadel, Christopher K Glass
- Immunity, 10.1016/j.immuni.2022.06.022
ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling
- William Hancock-Cerutti, Zheng Wu, Peng Xu, …, Shawn M Ferguson, Gerald S Shadel, Pietro De Camilli
- J Cell Biol, 10.1083/jcb.202106046
The San Diego Nathan Shock Center: tackling the heterogeneity of aging
- Gerald S Shadel, Peter D Adams, W Travis Berggren, …, Tatyana O Sharpee, Maxim N Shokriev, Stefania Zambetti
- Geroscience, 10.1007/s11357-021-00426-x
Mitochondrial DNA: cellular genotoxic stress sentinel
- Zheng Wu, Alva G Sainz, Gerald S Shadel, Zheng Wu, Alva G Sainz, Gerald S Shadel
- Trends Biochem Sci, 10.1016/j.tibs.2021.05.004
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2
- Yuyang Lei, Jiao Zhang, Cara R Schiavon, …, Shengpeng Wang, Zu-Yi Yuan, John Y-J Shyy
- Circ Res, 10.1161/circresaha.121.318902