Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor
- Narek Darabedian, Wenzhi Ji, Mengyang Fan, …, Tinghu Zhang, Nathanael S Gray, Edward T Chouchani
- Nat Chem Biol, 10.1038/s41589-023-01273-x
Architecture of the outbred brown fat proteome defines regulators of metabolic physiology
- Haopeng Xiao, Luiz H M Bozi, Yizhi Sun, …, Gary A Churchill, Steven P Gygi, Edward T Chouchani
- Cell, 10.1016/j.cell.2022.10.003
Career pathways, part 9
- Evanna L Mills, Edward T Chouchani
- Nat Metab, 10.1038/s42255-022-00624-7
Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function
- Lydia Dyck, Hannah Prendeville, Mathilde Raverdeau, …, Donal O’Shea, Donal Brennan, Lydia Lynch
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Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation
- Evanna L Mills, Cathal Harmon, Mark P Jedrychowski, …, Steven P Gygi, Bruce M Spiegelman, Edward T Chouchani
- Cell Metab, 10.1016/j.cmet.2021.11.003
UCP1 governs liver extracellular succinate and inflammatory pathogenesis
- Evanna L Mills, Cathal Harmon, Mark P Jedrychowski, …, Steven P Gygi, Lydia Lynch, Edward T Chouchani
- Nat Metab, 10.1038/s42255-021-00389-5
pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise
- Anita Reddy, Luiz H M Bozi, Omar K Yaghi, …, Erik A Richter, Diane Mathis, Edward T Chouchani
- Cell, 10.1016/j.cell.2020.08.039
Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction
- Hanumantha Rao Madala, Iiro Taneli Helenius, Wen Zhou, …, Othon Iliopoulos, Edward Chouchani, Jing-Ruey Joanna Yeh
- Cancer Res, 10.1158/0008-5472.can-20-0246
A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging
- Haopeng Xiao, Mark P Jedrychowski, Devin K Schweppe, …, Nathanael S Gray, Steven P Gygi, Edward T Chouchani
- Cell, 10.1016/j.cell.2020.02.012
Coupling Krebs cycle metabolites to signalling in immunity and cancer
- Dylan G Ryan, Michael P Murphy, Christian Frezza, …, Edward T Chouchani, Luke A O’Neill, Evanna L Mills
- Nat Metab, 10.1038/s42255-018-0014-7
Accumulation of succinate controls activation of adipose tissue thermogenesis
- Evanna L Mills, Kerry A Pierce, Mark P Jedrychowski, …, Steven P Gygi, Clary B Clish, Edward T Chouchani
- Nature, 10.1038/s41586-018-0353-2
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
- Evanna L Mills, Dylan G Ryan, Hiran A Prag, …, Richard C Hartley, Michael P Murphy, Luke A O’Neill
- Nature, 10.1038/nature25986