Scholar: Eric Siggia

Eric Siggia

Academic lineage

A geometrical perspective on development

  • Archishman Raju, Eric D Siggia, Archishman Raju, …, Eric D Siggia, Archishman Raju, Eric D Siggia
  • Dev Growth Differ, 10.1111/dgd.12855
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Mechanisms underlying WNT-mediated priming of human embryonic stem cells

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In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells

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Mechanical regulation of early vertebrate embryogenesis

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Human neural tube morphogenesis in vitro by geometric constraints

  • Aimal H Khankhel, Heitor C Megale, Stella M K Glasauer, …, Eric D Siggia, Boris I Shraiman, Sebastian J Streichan
  • Nature, 10.1038/s41586-021-04026-9
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Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions

  • Meritxell Sáez, Robert Blassberg, Elena Camacho-Aguilar, Eric D Siggia, David A Rand, James Briscoe
  • Cell Syst, 10.1016/j.cels.2021.08.013
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Geometry of gene regulatory dynamics

  • David A Rand, Archishman Raju, Meritxell Sáez, Francis Corson, Eric D Siggia
  • Proc Natl Acad Sci U S A, 10.1073/pnas.2109729118
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Differential compartmentalization of BMP4/NOGGIN requires NOGGIN trans-epithelial transport

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In vitro modeling of early mammalian embryogenesis

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Mapping cell migrations and fates in a gastruloid model to the human primitive streak

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A 3D model of a human epiblast reveals BMP4-driven symmetry breaking

  • Mijo Simunovic, Jakob J Metzger, Fred Etoc, …, Dong Shin You, Ali H Brivanlou, Eric D Siggia
  • Nat Cell Biol, 10.1038/s41556-019-0349-7
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Self-organization of stem cells into embryos: A window on early mammalian development

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