Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression
- Marco Sciacovelli, Aurelien Dugourd, Lorea Valcarcel Jimenez, …, Sakari Vanharanta, Julio Saez-Rodriguez, Christian Frezza
- Nat Commun, 10.1038/s41467-022-35036-4
Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses
- Mimmi L E Lundahl, Morgane Mitermite, Dylan Gerard Ryan, …, Luke A J O’Neill, Stephen V Gordon, Ed C Lavelle
- Elife, 10.7554/elife.74690
DIA label-free proteomic analysis of murine bone-marrow-derived macrophages
- Christa P Baker, Iain R Phair, Alejandro J Brenes, …, Douglas J Lamont, J Simon C Arthur, Andrew J M Howden
- STAR Protoc, 10.1016/j.xpro.2022.101725
Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response
- Dylan G Ryan, Elena V Knatko, Alva M Casey, …, Doreen A Cantrell, Michael P Murphy, Albena T Dinkova-Kostova
- None, 10.1016/j.isci.2022.103827
Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism
- Dylan Gerard Ryan, Ming Yang, Hiran A Prag, …, Michael P Murphy, Alex von Kriegsheim, Christian Frezza
- Elife, 10.7554/elife.72593
TCA cycle signalling and the evolution of eukaryotes
- Dylan G Ryan, Christian Frezza, Luke Aj O’Neill
- Curr Opin Biotechnol, 10.1016/j.copbio.2020.09.014
Caspase-11 promotes allergic airway inflammation
- Zbigniew ZasÅ‚ona, Ewelina Flis, Mieszko M Wilk, …, MaÅ‚gorzata Wygrecka, Emma M Creagh, Luke A J O’Neill
- Nat Commun, 10.1038/s41467-020-14945-2
Krebs Cycle Reborn in Macrophage Immunometabolism
- Dylan G Ryan, Luke A J O’Neill
- Annu Rev Immunol, 10.1146/annurev-immunol-081619-104850
Coupling Krebs cycle metabolites to signalling in immunity and cancer
- Dylan G Ryan, Michael P Murphy, Christian Frezza, …, Edward T Chouchani, Luke A O’Neill, Evanna L Mills
- Nat Metab, 10.1038/s42255-018-0014-7
Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming
- David Olagnier, Aske M Brandtoft, Camilla Gunderstofte, …, Martin R Jakobsen, Thomas B Poulsen, Christian K Holm
- Nat Commun, 10.1038/s41467-018-05861-7
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
- Evanna L Mills, Dylan G Ryan, Hiran A Prag, …, Richard C Hartley, Michael P Murphy, Luke A O’Neill
- Nature, 10.1038/nature25986