Tailored extraction and ion mobility-mass spectrometry enables isotopologue analysis of tetrahydrofolate vitamers
- Bernd M Mitic, Diethard Mattanovich, Stephan Hann, …, Diethard Mattanovich, Stephan Hann, Tim Causon
- Anal Bioanal Chem, 10.1007/s00216-023-04786-5
Synthetic two-species allodiploid and three-species allotetraploid Saccharomyces hybrids with euploid (complete) parental subgenomes
- Zsuzsa Antunovics, Adrienn Szabo, Lina Heistinger, …, Lina Heistinger, Diethard Mattanovich, Matthias Sipiczki
- Sci Rep, 10.1038/s41598-023-27693-2
Synthetic activation of yeast stress response improves secretion of recombinant proteins
- Richard J Zahrl, Roland Prielhofer, Jonas Burgard, …, Jonas Burgard, Diethard Mattanovich, Brigitte Gasser
- N Biotechnol, 10.1016/j.nbt.2023.01.001
Conversion of CO 2 into organic acids by engineered autotrophic yeast
- Michael Baumschabl, Özge Ata, Bernd M Mitic, …, Christina Troyer, Stephan Hann, Diethard Mattanovich
- Proc Natl Acad Sci U S A, 10.1073/pnas.2211827119
Pushing and pulling proteins into the yeast secretory pathway enhances recombinant protein secretion
- Richard J Zahrl, Roland Prielhofer, Özge Ata, Kristin Baumann, Diethard Mattanovich, Brigitte Gasser
- Metab Eng, 10.1016/j.ymben.2022.08.010
From strain engineering to process development: monoclonal antibody production with an unnatural amino acid in Pichia pastoris
- Nora Tir, Lina Heistinger, Clemens Grünwald-Gruber, …, Stephan Dickgiesser, Nicolas Rasche, Diethard Mattanovich
- Microb Cell Fact, 10.1186/s12934-022-01882-6
Metabolic engineering of Pichia pastoris for myo-inositol production by dynamic regulation of central metabolism
- Qiquan Zhang, Xiaolu Wang, Huiying Luo, …, Bin Yao, Yingguo Bai, Jie Zhang
- Microb Cell Fact, 10.1186/s12934-022-01837-x
Genotypic and phenotypic diversity among Komagataella species reveals a hidden pathway for xylose utilization
- Lina Heistinger, Juliane C Dohm, Barbara G Paes, …, Özge Ata, Teresa Steininger-Mairinger, Diethard Mattanovich
- Microb Cell Fact, 10.1186/s12934-022-01796-3
Going beyond the limit: Increasing global translation activity leads to increased productivity of recombinant secreted proteins in Pichia pastoris
- Jennifer Staudacher, Corinna Rebnegger, Thomas Dohnal, Nils Landes, Diethard Mattanovich, Brigitte Gasser
- Metab Eng, 10.1016/j.ymben.2022.01.010
Adaptive laboratory evolution and reverse engineering enhances autotrophic growth in Pichia pastoris
- Thomas Gassler, Michael Baumschabl, Jakob Sallaberger, Michael Egermeier, Diethard Mattanovich
- Metab Eng, 10.1016/j.ymben.2021.11.007
Fermenting Futures: an artistic view on yeast biotechnology
- Anna Dumitriu, Alex May, Özge Ata, Diethard Mattanovich
- FEMS Yeast Res, 10.1093/femsyr/foab042
Two homologs of the Cat8 transcription factor are involved in the regulation of ethanol utilization in Komagataella phaffii
- Diane Barbay, Monika Mačáková, Leander Sützl, Sonakshi De, Diethard Mattanovich, Brigitte Gasser
- Curr Genet, 10.1007/s00294-021-01165-4
Beyond alcohol oxidase: the methylotrophic yeast Komagataella phaffii utilizes methanol also with its native alcohol dehydrogenase Adh2
- Domen Zavec, Christina Troyer, Daniel Maresch, …, Stephan Hann, Brigitte Gasser, Diethard Mattanovich
- FEMS Yeast Res, 10.1093/femsyr/foab009
Fine-Tuning of Transcription in Pichia pastoris Using dCas9 and RNA Scaffolds
- Michael Baumschabl, Roland Prielhofer, Diethard Mattanovich, Matthias G Steiger
- ACS Synth Biol, 10.1021/acssynbio.0c00214
Pseudohyphal differentiation in Komagataella phaffii: investigating the FLO gene family
- Sonakshi De, Corinna Rebnegger, Josef Moser, …, Alexandra B Graf, Diethard Mattanovich, Brigitte Gasser
- FEMS Yeast Res, 10.1093/femsyr/foaa044
Microbe Profile: Komagataella phaffii : a methanol devouring biotech yeast formerly known as Pichia pastoris
- Lina Heistinger, Brigitte Gasser, Diethard Mattanovich
- Microbiology (Reading), 10.1099/mic.0.000958
Impacts on product quality attributes of monoclonal antibodies produced in CHO cell bioreactor cultures during intentional mycoplasma contamination events
- Erica J Fratz-Berilla, Phillip Angart, Ryan J Graham, …, Sai Rashmika Velugula-Yellela, Nicholas Trunfio, Cyrus Agarabi
- Biotechnol Bioeng, 10.1002/bit.27436
Komagataella phaffii YPS1-5 encodes the alpha-factor degrading protease Bar1
- Lina Heistinger, Brigitte Gasser, Diethard Mattanovich
- FEMS Yeast Res, 10.1093/femsyr/foaa024
Characterization of methanol utilization negative Pichia pastoris for secreted protein production: New cultivation strategies for current and future applications
- Domen Zavec, Brigitte Gasser, Diethard Mattanovich
- Biotechnol Bioeng, 10.1002/bit.27303
The industrial yeast Pichia pastoris is converted from a heterotroph into an autotroph capable of growth on CO 2
- Thomas Gassler, Michael Sauer, Brigitte Gasser, …, Stephan Hann, Diethard Mattanovich, Matthias G Steiger
- Nat Biotechnol, 10.1038/s41587-019-0363-0
Disruption of vacuolar protein sorting components of the HOPS complex leads to enhanced secretion of recombinant proteins in Pichia pastoris
- Lukas Marsalek, Verena Puxbaum, Markus Buchetics, Diethard Mattanovich, Brigitte Gasser
- Microb Cell Fact, 10.1186/s12934-019-1155-4
Detection and Elimination of Cellular Bottlenecks in Protein-Producing Yeasts
- Richard J Zahrl, Brigitte Gasser, Diethard Mattanovich, Pau Ferrer
- Methods Mol Biol, 10.1007/978-1-4939-9024-5_2
CRISPR/Cas9-Mediated Homology-Directed Genome Editing in Pichia pastoris
- Thomas Gassler, Lina Heistinger, Diethard Mattanovich, Brigitte Gasser, Roland Prielhofer
- Methods Mol Biol, 10.1007/978-1-4939-9024-5_9
Engineering of the citrate exporter protein enables high citric acid production in Aspergillus niger
- Matthias G Steiger, Alice Rassinger, Diethard Mattanovich, Michael Sauer
- Metab Eng, 10.1016/j.ymben.2018.12.004
A single Gal4-like transcription factor activates the Crabtree effect in Komagataella phaffii
- Özge Ata, Corinna Rebnegger, Nadine E Tatto, …, Matthias G Steiger, Pınar Çalık, Diethard Mattanovich
- Nat Commun, 10.1038/s41467-018-07430-4
